scholarly journals Beware of white matter hyperintensities causing systematic errors in FreeSurfer gray matter segmentations!

2021 ◽  
Author(s):  
Mahsa Dadar ◽  
Olivier Potvin ◽  
Richard Camicioli ◽  
Simon Duchesne ◽  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Systematic Errors

scholarly journals Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Malo Gaubert ◽  
Catharina Lange ◽  
Antoine Garnier-Crussard ◽  
Theresa Köbe ◽  
Salma Bougacha ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Glucose Metabolism ◽  
Corpus Callosum ◽  
Gray Matter ◽  
Fdg Pet ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume

Abstract Background White matter hyperintensities (WMH) are frequently found in Alzheimer’s disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH associated with Aβ burden, glucose hypometabolism, and gray matter volume reduction. Methods In a total of 155 participants (IMAP+ cohort) across the cognitive continuum from normal cognition to AD dementia, FLAIR MRI, AV45-PET, FDG-PET, and T1 MRI were acquired. WMH were automatically segmented from FLAIR images. Mean levels of neocortical Aβ deposition (AV45-PET), temporo-parietal glucose metabolism (FDG-PET), and medial-temporal gray matter volume (GMV) were extracted from processed images using established AD meta-signature templates. Associations between AD brain biomarkers and WMH, as assessed in region-of-interest and voxel-wise, were examined, adjusting for age, sex, education, and systolic blood pressure. Results There were no significant associations between global Aβ burden and region-specific WMH. Voxel-wise WMH in the splenium of the corpus callosum correlated with greater Aβ deposition at a more liberal threshold. Region- and voxel-based WMH in the posterior corpus callosum, along with parietal, occipital, and frontal areas, were associated with lower temporo-parietal glucose metabolism. Similarly, lower medial-temporal GMV correlated with WMH in the posterior corpus callosum in addition to parietal, occipital, and fontal areas. Conclusions This study demonstrates that local white matter damage is correlated with multimodal brain biomarkers of AD. Our results highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter. Overall, these cross-sectional findings corroborate associations of regional WMH with AD-typical Aß deposition and neurodegeneration.

Correlation between degree of white matter hyperintensities and global gray matter volume decline rate

2010 ◽  
Vol 53 (6) ◽  
pp. 397-403 ◽  
Author(s):  
Yasuyuki Taki ◽  
Shigeo Kinomura ◽  
Kazunori Sato ◽  
Ryoi Goto ◽  
Kai Wu ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Decline Rate

scholarly journals Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment

2015 ◽  
Vol 221 (4) ◽  
pp. 2135-2146 ◽  
Author(s):  
Zoe Arvanitakis ◽  
Debra A. Fleischman ◽  
Konstantinos Arfanakis ◽  
Sue E. Leurgans ◽  
Lisa L. Barnes ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Older Individuals ◽  
Matter Volume

scholarly journals White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

2019 ◽  
Vol 41 (5) ◽  
pp. 1309-1322 ◽  
Author(s):  
Anna Brugulat‐Serrat ◽  
Gemma Salvadó ◽  
Grégory Operto ◽  
Raffaele Cacciaglia ◽  
Carole H. Sudre ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Processing Speed ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume

scholarly journals Evidence of Subtle Gray-Matter Pathologic Changes in Healthy Elderly Individuals With Nonspecific White-Matter Hyperintensities

2003 ◽  
Vol 60 (8) ◽  
pp. 1109 ◽  
Author(s):  
Domenico Maria Mezzapesa ◽  
Maria Assunta Rocca ◽  
Elisabetta Pagani ◽  
Giancarlo Comi ◽  
Massimo Filippi
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Elderly Individuals ◽  
Healthy Elderly

White Matter Hyperintensities and Gray Matter Lesions in Physically Healthy Depressed Subjects

1999 ◽  
Vol 156 (10) ◽  
pp. 1602-1607 ◽  
Author(s):  
Eric Lenze ◽  
DeWitte Cross ◽  
Daniel McKeel ◽  
Rosalind J. Neuman ◽  
Yvette I. Sheline
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities
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