scholarly journals White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

2019 ◽  
Vol 41 (5) ◽  
pp. 1309-1322 ◽  
Author(s):  
Anna Brugulat‐Serrat ◽  
Gemma Salvadó ◽  
Grégory Operto ◽  
Raffaele Cacciaglia ◽  
Carole H. Sudre ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
Processing Speed ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume

scholarly journals Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Malo Gaubert ◽  
Catharina Lange ◽  
Antoine Garnier-Crussard ◽  
Theresa Köbe ◽  
Salma Bougacha ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Glucose Metabolism ◽  
Corpus Callosum ◽  
Gray Matter ◽  
Fdg Pet ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume

Abstract Background White matter hyperintensities (WMH) are frequently found in Alzheimer’s disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH associated with Aβ burden, glucose hypometabolism, and gray matter volume reduction. Methods In a total of 155 participants (IMAP+ cohort) across the cognitive continuum from normal cognition to AD dementia, FLAIR MRI, AV45-PET, FDG-PET, and T1 MRI were acquired. WMH were automatically segmented from FLAIR images. Mean levels of neocortical Aβ deposition (AV45-PET), temporo-parietal glucose metabolism (FDG-PET), and medial-temporal gray matter volume (GMV) were extracted from processed images using established AD meta-signature templates. Associations between AD brain biomarkers and WMH, as assessed in region-of-interest and voxel-wise, were examined, adjusting for age, sex, education, and systolic blood pressure. Results There were no significant associations between global Aβ burden and region-specific WMH. Voxel-wise WMH in the splenium of the corpus callosum correlated with greater Aβ deposition at a more liberal threshold. Region- and voxel-based WMH in the posterior corpus callosum, along with parietal, occipital, and frontal areas, were associated with lower temporo-parietal glucose metabolism. Similarly, lower medial-temporal GMV correlated with WMH in the posterior corpus callosum in addition to parietal, occipital, and fontal areas. Conclusions This study demonstrates that local white matter damage is correlated with multimodal brain biomarkers of AD. Our results highlight modality-specific topographic patterns of WMH, which converged in the posterior white matter. Overall, these cross-sectional findings corroborate associations of regional WMH with AD-typical Aß deposition and neurodegeneration.

Correlation between degree of white matter hyperintensities and global gray matter volume decline rate

2010 ◽  
Vol 53 (6) ◽  
pp. 397-403 ◽  
Author(s):  
Yasuyuki Taki ◽  
Shigeo Kinomura ◽  
Kazunori Sato ◽  
Ryoi Goto ◽  
Kai Wu ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Decline Rate

scholarly journals Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment

2015 ◽  
Vol 221 (4) ◽  
pp. 2135-2146 ◽  
Author(s):  
Zoe Arvanitakis ◽  
Debra A. Fleischman ◽  
Konstantinos Arfanakis ◽  
Sue E. Leurgans ◽  
Lisa L. Barnes ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Older Individuals ◽  
Matter Volume

scholarly journals P3-323: WHITE MATTER HYPERINTENSITIES MEDIATE THE RELATIONSHIP BETWEEN GRAY MATTER VOLUME AND EXECUTIVE FUNCTION IN COGNITIVELY UNIMPAIRED MIDDLE-AGED INDIVIDUALS

2019 ◽  
Vol 15 ◽  
pp. P1061-P1062
Author(s):  
Anna Brugulat-Serrat ◽  
Gemma Salvadó ◽  
Grégory Operto ◽  
Raffaele Cacciaglia ◽  
Carole H. Sudre ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Middle Aged ◽  
Matter Volume ◽  
The Relationship

P3-203: BRAIN WHITE MATTER HYPERINTENSITIES MEDIATE THE RELATION OF GRAY MATTER VOLUME TO PERCEPTUAL SPEED IN INDIVIDUALS WITHOUT COGNITIVE IMPAIRMENT

2014 ◽  
Vol 10 ◽  
pp. P704-P705
Author(s):  
Zoe Arvanitakis ◽  
Debra A. Fleischman ◽  
Konstantinos Arfanakis ◽  
Sue Leurgans ◽  
Lisa L. Barnes ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Perceptual Speed ◽  
Matter Volume ◽  
Brain White Matter

IC-P-132: BASELINE WHITE MATTER HYPERINTENSITIES AND GRAY MATTER VOLUME INDEPENDENTLY PREDICT COGNITIVE TRAJECTORIES IN ADNI II

2014 ◽  
Vol 10 ◽  
pp. P76-P76
Author(s):  
Charles DeCarli ◽  
Owen Thomas Carmichael ◽  
Oliver Martinez ◽  
Baljeet Singh ◽  
Evan Fletcher ◽  
...  
Keyword(s):  
White Matter ◽  
Gray Matter ◽  
White Matter Hyperintensities ◽  
Gray Matter Volume ◽  
Matter Volume
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