scholarly journals Interregional causal influences of brain metabolic activity reveal the spread of aging effects during normal aging

2019 ◽  
Vol 40 (16) ◽  
pp. 4657-4668 ◽  
Author(s):  
Xin Di ◽  
Marie Wölfer ◽  
Mario Amend ◽  
Hans Wehrl ◽  
Tudor M. Ionescu ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
Normal Aging ◽  
Aging Effects ◽  
Brain Metabolic Activity

scholarly journals Interregional causal influences of brain metabolic activity reveal the spread of aging effects during normal aging

2018 ◽  
Author(s):  
Xin Di ◽  
Marie Wölfer ◽  
Mario Amend ◽  
Hans Wehrl ◽  
Tudor M. Ionescu ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
Fdg Pet ◽  
Aging Process ◽  
Brain Aging ◽  
Brain Regions ◽  
Causality Analysis ◽  
Aging Effects ◽  
Activity Data ◽  
Age Related ◽  
Brain Metabolic Activity

AbstractDuring healthy brain aging, different brain regions show anatomical or functional declines at different rates, and some regions may show compensatory increases in functional activity. However, few studies have explored interregional influences of brain activity during the aging process. We proposed a causality analysis framework combining high dimensionality independent component analysis (ICA), Granger causality, and LASSO (least absolute shrinkage and selection operator) regression on longitudinal brain metabolic activity data measured by Fludeoxyglucose positron emission tomography (FDG-PET). We analyzed FDG-PET images from healthy old subjects, who were scanned for at least five sessions with an averaged intersession interval of about one year. The longitudinal data were concatenated across subjects to form a time series, and the first order autoregressive model was used to measure interregional causality among the independent sources of metabolic activity identified using ICA. Several independent sources with reduced metabolic activity in aging, including the anterior temporal lobe and orbital frontal cortex, demonstrated causal influences over many widespread brain regions. On the other hand, the influenced regions were more distributed, and had smaller age related declines or even relatively increased metabolic activity. The current data demonstrated interregional spreads of aging on metabolic activity at the scale of a year, and have identified key brain regions in the aging process that have strong influences over other regions.

scholarly journals Processing speed in normal aging: Effects of white matter hyperintensities and hippocampal volume loss

2013 ◽  
Vol 21 (2) ◽  
pp. 197-213 ◽  
Author(s):  
Kathryn V. Papp ◽  
Richard F. Kaplan ◽  
Beth Springate ◽  
Nicola Moscufo ◽  
Dorothy B. Wakefield ◽  
...  
Keyword(s):  
White Matter ◽  
Processing Speed ◽  
White Matter Hyperintensities ◽  
Hippocampal Volume ◽  
Normal Aging ◽  
Volume Loss ◽  
Aging Effects

scholarly journals What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

2014 ◽  
Vol 117 ◽  
pp. 20-40 ◽  
Author(s):  
Anders M. Fjell ◽  
Linda McEvoy ◽  
Dominic Holland ◽  
Anders M. Dale ◽  
Kristine B. Walhovd
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Cortex ◽  
Normal Aging ◽  
Aging Effects ◽  
Effects Of Aging

#111 Intraperitoneal lipopolysaccharide produces changes in brain metabolic activity as measured by [18F]FDG in the rat

2005 ◽  
Vol 19 (4) ◽  
pp. e57-e58
Author(s):  
Gregory H. Pelton ◽  
Leon N. Lyazidi ◽  
Raymond C. Chang ◽  
Davangere P. Devanand ◽  
Harold A. Sackheim ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
18F Fdg ◽  
Brain Metabolic Activity

Resting Brain Metabolic Activity in Identical Twins Discordant for Combat Exposure

2008 ◽  
Author(s):  
Lisa Shin ◽  
Milad Mohammed ◽  
Natasha Lasko ◽  
Alan Fischman ◽  
Scott Rauch ◽  
...  
Keyword(s):  
Metabolic Activity ◽  
Combat Exposure ◽  
Identical Twins ◽  
Brain Metabolic Activity

scholarly journals Alterations of Striato-Thalamic Metabolism in Normal Aging Human Brain—An MR Metabolic Imaging Study

Metabolites ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 371
Author(s):  
Mareike Ahlswede ◽  
Patrick Nösel ◽  
Andrew A. Maudsley ◽  
Sulaiman Sheriff ◽  
Nima Mahmoudi ◽  
...  
Keyword(s):  
Caudate Nucleus ◽  
Linear Regression Analysis ◽  
Normal Aging ◽  
Spatial Inhomogeneity ◽  
Metabolic Imaging ◽  
Aging Effects ◽  
Tissue Water ◽  
Healthy Human ◽  
Metabolite Concentrations

Aging effects on striato-thalamic metabolism in healthy human brains were studied in vivo using short-TE whole brain 1H-MR spectroscopic imaging (wbMRSI) on eighty healthy subjects aged evenly between 20 to 70 years at 3T. Relative concentrations of N-acetyl-aspartate (NAA), choline, total creatine (tCr), myo-inositol (mI), glutamate, and glutamine in bilateral caudate nucleus, putamen, pallidum, and thalamus were determined using signal normalization relative to brain tissue water. Linear regression analysis was used to analyze the age-dependence of the metabolite concentrations. The metabolite concentrations revealed spatial inhomogeneity across brain regions and metabolites. With age, NAA decreased significantly in bilateral caudate nucleus and putamen, left pallidum, and left thalamus, tCr decreased in left putamen and bilateral pallidum, mI increased in bilateral caudate nucleus and right thalamus, and spectral linewidth increased in left putamen and right thalamus. In conclusion, normal aging of striato-thalamic metabolism in healthy human is associated with regional specific decreases of NAA and tCr and increases of mI, which may reflect the individual role of each brain structure within brain functionality.

The effects of hyperammonemia in learning and brain metabolic activity

2014 ◽  
Vol 29 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Natalia Arias ◽  
Camino Fidalgo ◽  
Vicente Felipo ◽  
Jorge L. Arias
Keyword(s):  
Metabolic Activity ◽  
Brain Metabolic Activity

scholarly journals Three word recall in normal aging: Effects of explicit prompts

1999 ◽  
Vol 14 (1) ◽  
pp. 83-83
Author(s):  
L. H. Lacritz ◽  
T. Cicerello ◽  
C. S. Bond ◽  
L. Honig ◽  
M. Weiner ◽  
...  
Keyword(s):  
Normal Aging ◽  
Word Recall ◽  
Aging Effects
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