scholarly journals Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

2019 ◽  
Vol 40 (15) ◽  
pp. 4537-4550 ◽  
Author(s):  
Arianna Sala ◽  
Silvia Paola Caminiti ◽  
Leonardo Iaccarino ◽  
Luca Beretta ◽  
Sandro Iannaccone ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Large Scale ◽  
Brain Networks ◽  
Lewy Bodies

scholarly journals Altered structural connectivity networks in dementia with lewy bodies

2021 ◽  
Author(s):  
Nicolas Nicastro ◽  
Elijah Mak ◽  
Ajenthan Surendranathan ◽  
Timothy Rittman ◽  
James B. Rowe ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Dementia With Lewy Bodies ◽  
Large Scale ◽  
Brain Networks ◽  
Structural Connectivity ◽  
Lewy Bodies ◽  
Occipital Lobe ◽  
Mri Imaging ◽  
Structural Networks ◽  
Graph Parameters

AbstractThe impairment of large-scale brain networks has been observed in dementia with Lewy bodies (DLB) using functional connectivity, but the potential for an analogous effect on structural covariance patterns has not been determined. Twenty-four probable DLB subjects (mean age 74.3 ± 6.7 years, 16.7% female) and 23 similarly aged Controls were included. All participants underwent 3T MRI imaging with high-resolution T1-weighted magnetization-prepared rapid gradient echo (MPRAGE) sequence. Graph theoretical analyses were performed using variation in regional cortical thickness to construct a structural association matrix with pairwise Pearson correlations. Global and nodal graph parameters were computed to assess between-group differences and community structure was studied in order to quantify large-scale brain networks in both groups. In comparison to Controls, DLB subjects had decreased global efficiency, clustering, modularity and small-worldness of structural networks (all p < 0.05). Nodal measures showed that DLB subjects also had decreased clustering in bilateral temporal regions and decreased closeness centrality in extensive areas including right middle frontal, left cingulate and bilateral occipital lobe (all false-discovery rate (FDR)-corrected q < 0.05). Whereas four distinct modules could be clearly identified in Controls, DLB showed extensively disorganized modules, including default-mode network and dorsal attentional network. Our results suggest a marked impairment in large-scale brain structural networks in DLB, mirroring functional connectivity networks disruption.

scholarly journals Heritability and genetic variance of dementia with Lewy bodies

2018 ◽  
Author(s):  
Rita Guerreiro ◽  
Valentina Escott-Price ◽  
Dena G. Hernandez ◽  
Celia Kun-Rodrigues ◽  
Owen A. Ross ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Complex Traits ◽  
Dementia With Lewy Bodies ◽  
Large Scale ◽  
Lewy Bodies ◽  
Significant Snps ◽  
Risk Scores ◽  
Phenotypic Variance ◽  
Appreciable Effect ◽  
Risk Variants

AbstractRecent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established that a substantial portion of the genetic heritable component of complex traits is not captured by genome-wide significant SNPs. To overcome this issue, we have estimated the proportion of phenotypic variance explained by genetic variability (SNP heritability) in DLB using a method that is unbiased by allele frequency or linkage disequilibrium properties of the underlying variants. This shows that the heritability of DLB is nearly twice as high as previous estimates based on common variants only (31% vs 59.9%). We also determine the amount of phenotypic variance in DLB that can be explained by recent polygenic risk scores from either Parkinson’s disease (PD) or Alzheimer’s disease (AD), and show that, despite being highly significant, they explain a low amount of variance. Additionally, to identify pleiotropic events that might improve our understanding of the disease, we performed genetic correlation analyses of DLB with over 200 diseases and biomedically relevant traits. Our data shows that DLB has a positive correlation with education phenotypes, which is opposite to what occurs in AD. Overall, our data suggests that novel genetic risk factors for DLB should be identified by larger GWAS and these are likely to be independent from known AD and PD risk variants.

scholarly journals Incidence and Comorbidity of Dementia with Lewy Bodies: A Population-Based Cohort Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Sheng-Kung Yang ◽  
Weishan Chen ◽  
Chun-Hsien Su ◽  
Chung-Hsiang Liu
Keyword(s):  
Cohort Study ◽  
Dementia With Lewy Bodies ◽  
Large Scale ◽  
Retrospective Studies ◽  
Lewy Bodies ◽  
Epidemiological Studies ◽  
Population Based ◽  
Research Database ◽  
The Third ◽  
Taiwan National Health Insurance

Background and Aims. Dementia with Lewy bodies (DLB) is the third most common form of dementia. Epidemiological studies of DLB in Taiwan are scarce. In this study, we estimated the incidence of DLB and comorbidity in the population of Taiwan. Methods. Data were obtained from the Taiwan National Health Insurance Research Database (NHIRD). DLB patients between 2000 and 2013 were enrolled in assessments of incidence and comorbidity. Results. The incidence of DLB was shown to be 7.10 per 100,000 person-years (95% CI = 6.63–7.59), which increased with age. The average age at diagnosis was 76.3, and this was higher for males than for females. The comorbidity rates of hypertension and hyperlipidemia in DLB patients were higher in females than in males. Conclusions. Epidemiologic data from large-scale retrospective studies is crucial to the prevention of DLB.

Differences in glucose metabolism between dementia with Lewy bodies and dementia associated with Parkinson's disease

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
P Häussermann ◽  
A.O Ceballos-Baumann ◽  
H Förstl ◽  
R Feurer ◽  
B Conrad ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Glucose Metabolism ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

Dementia with Lewy bodies

2018 ◽  
pp. 11-21
Author(s):  
O. S. Levin ◽  
E. E. Vasenina ◽  
A. Sh. Chimagomedova ◽  
N. G. Dudchenko
Keyword(s):  
Parkinson’S Disease ◽  
Dementia With Lewy Bodies ◽  
Cholinesterase Inhibitors ◽  
Lewy Bodies ◽  
Diagnosis And Treatment ◽  
Modern Concept ◽  
Historical Aspect ◽  
Neurodegenerative Process ◽  
Icd 10

Te lecture presents modern concept of the symptoms, diagnosis and treatment of dementia with Lewy bodies (DLB), which accounts for about 10% of cases of dementia. Te nosological status of DLB and the problem of ratio of DLB and Parkinson’s disease which, apparently, represent two phenotypic variants of one neurodegenerative process («diseases with Lewy bodies») are considered in historical aspect. Approaches to the diagnosis and coding of DLB in accordance with ICD-10 are proposed. Te role of cholinesterase inhibitors, antipsychotics, levodopa, rasagiline and other drugs in the treatment of patients with DLB is аnalyzed.

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