Supplemental Material for Visuospatial Deficits Predict Rate of Cognitive Decline in Autopsy-Verified Dementia With Lewy Bodies

2008 ◽  
Keyword(s):  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visuospatial Deficits

scholarly journals Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies.

2008 ◽  
Vol 22 (6) ◽  
pp. 729-737 ◽  
Author(s):  
Joanne M. Hamilton ◽  
David P. Salmon ◽  
Douglas Galasko ◽  
Rema Raman ◽  
Jenn Emond ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visuospatial Deficits

scholarly journals A systematic review of cognitive decline in dementia with Lewy bodies versus Alzheimer’s disease

2014 ◽  
Vol 6 (5-8) ◽  
Author(s):  
Monica H Breitve ◽  
Luiza J Chwiszczuk ◽  
Minna J Hynninen ◽  
Arvid Rongve ◽  
Kolbjørn Brønnick ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

scholarly journals Apathy is associated with faster global cognitive decline and early nursing home admission in dementia with Lewy bodies

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Monica H. Breitve ◽  
Kolbjørn Brønnick ◽  
Luiza J. Chwiszczuk ◽  
Minna J. Hynninen ◽  
Dag Aarsland ◽  
...  
Keyword(s):  
Nursing Home ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Nursing Home Admission

scholarly journals VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies

2019 ◽  
Vol 20 (19) ◽  
pp. 4674 ◽  
Author(s):  
Inger van Steenoven ◽  
Barbara Noli ◽  
Cristina Cocco ◽  
Gian-Luca Ferri ◽  
Patrick Oeckl ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Decline ◽  
Analytical Methods ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Disease Stage ◽  
Selected Reaction Monitoring ◽  
Csf Biomarkers ◽  
Potential Biomarker ◽  
Proteomic Study

In a previous proteomic study, we identified the neurosecretory protein VGF (VGF) as a potential biomarker for dementia with Lewy bodies (DLB). Here, we extended the study of VGF by comparing levels in cerebrospinal fluid (CSF) from 44 DLB patients, 20 Alzheimer’s disease (AD) patients, and 22 cognitively normal controls selected from the Amsterdam Dementia Cohort. CSF was analyzed using two orthogonal analytical methods: (1) In-house-developed quantitative ELISA and (2) selected reaction monitoring (SRM). We further addressed associations of VGF with other CSF biomarkers and cognition. VGF levels were lower in CSF from patients with DLB compared to either AD patients or controls. VGF was positively correlated with CSF tau and α-synuclein (0.55 < r < 0.75), but not with Aβ1-42. In DLB patients, low VGF levels were related to a more advanced cognitive decline at time of first presentation, whereas high levels of VGF were associated with steeper subsequent longitudinal cognitive decline. Hence, CSF VGF levels were lower in DLB compared to both AD and controls across different analytical methods. The strong associations with cognitive decline further points out VGF as a possible disease stage or prognostic marker for DLB.

scholarly journals Comparison of cognitive decline between dementia with Lewy bodies and Alzheimer's disease: a cohort study

BMJ Open ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. e000380 ◽  
Author(s):  
Zuzana Walker ◽  
Ian McKeith ◽  
Joanne Rodda ◽  
Tarik Qassem ◽  
Klaus Tatsch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cohort Study ◽  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies

O4-06-02: CSF AD-PROFILE IN DEMENTIA WITH LEWY BODIES: EFFECT ON CLINICAL PARAMETERS AND COGNITIVE DECLINE

2014 ◽  
Vol 10 ◽  
pp. P261-P262
Author(s):  
Afina W. Lemstra ◽  
Sietske A. Sikkes ◽  
Charlotte E. Teunissen ◽  
Annelies van der Vlies ◽  
Philip Scheltens
Keyword(s):  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Clinical Parameters

scholarly journals Verbal and visuospatial deficits in dementia with Lewy bodies

Neurology ◽  
2005 ◽  
Vol 65 (8) ◽  
pp. 1232-1238 ◽  
Author(s):  
D. K. Johnson ◽  
J. C. Morris ◽  
J. E. Galvin
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visuospatial Deficits

Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline

Synapse ◽  
2007 ◽  
Vol 61 (11) ◽  
pp. 903-911 ◽  
Author(s):  
Margaret A. Piggott ◽  
Clive G. Ballard ◽  
Elise Rowan ◽  
Clive Holmes ◽  
Ian G. McKeith ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Dementia With Lewy Bodies ◽  
Temporal Cortex ◽  
Lewy Bodies ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Dopamine D2 ◽  
Selective Loss

Dementia and Parkinson’s disease

2020 ◽  
pp. 115-118
Author(s):  
Rodolfo Savica ◽  
Pierpaolo Turcano
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Decline ◽  
Neurodegenerative Disease ◽  
Diagnostic Criteria ◽  
Symptom Onset ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Geographic Locations ◽  
Epidemiological Characteristics

Parkinson’s disease (PD) is a neurodegenerative disease that shares a number of clinical, pathological, and epidemiological characteristics with dementing illnesses. In addition, PD and related disorders have been associated with cognitive decline/dementia. The timeline of the symptom onset as well as the clinical phenotypes are crucial to define the diseases such as dementia with Lewy bodies and Parkinson’s disease dementia. The epidemiological figures of prevalence and incidence are somewhat limited, but are influenced by diagnostic criteria, geographic locations, and methodological limitations. However, it seems that age has a major role in the increase of prevalence and incidence of PD and dementia; additionally men seem to be consistently more affected than women.

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