scholarly journals Disrupted brain network topology in pediatric posttraumatic stress disorder: A resting-state fMRI study

2015 ◽  
Vol 36 (9) ◽  
pp. 3677-3686 ◽  
Author(s):  
Xueling Suo ◽  
Du Lei ◽  
Kaiming Li ◽  
Fuqin Chen ◽  
Fei Li ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Network Topology ◽  
Resting State ◽  
Stress Disorder ◽  
Resting State Fmri ◽  
Brain Network ◽  
Fmri Study

scholarly journals Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder

2019 ◽  
Vol 3 ◽  
pp. 247054701985046 ◽  
Author(s):  
Chadi G. Abdallah ◽  
Christopher L. Averill ◽  
Amy E. Ramage ◽  
Lynnette A. Averill ◽  
Selin Goktas ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Resting State ◽  
Stress Disorder ◽  
Right Hemisphere ◽  
Brain Network ◽  
Data Driven ◽  
Salience Network ◽  
Symptom Provocation ◽  
Army Soldiers

Background Better understanding of the neurobiology of posttraumatic stress disorder (PTSD) may be critical to developing novel, effective therapeutics. Here, we conducted a data-driven investigation using a well-established, graph-based topological measure of nodal strength to determine the extent of functional dysconnectivity in a cohort of active duty U.S. Army soldiers with PTSD compared to controls. Methods A total of 102 participants with (n = 50) or without PTSD (n = 52) completed functional magnetic resonance imaging at rest and during symptom provocation using subject-specific script imagery. Vertex/voxel global brain connectivity with global signal regression (GBCr), a measure of nodal strength, was calculated as the average of its functional connectivity with all other vertices/voxels in the brain gray matter. Results In contrast to resting state, where there were no group differences, we found a significantly higher GBCr during symptom provocation, in PTSD participants compared to controls, in areas within the right hemisphere, including anterior insula, caudal-ventrolateral prefrontal, and rostral-ventrolateral parietal cortices. Overall, these clusters overlapped with the ventral and dorsal salience networks. Post hoc analysis showed increased GBCr in these salience clusters during symptom provocation compared to resting state. In addition, resting-state GBCr in the salience clusters predicted GBCr during symptom provocation in PTSD participants but not in controls. Conclusion In PTSD, increased connectivity within the salience network has been previously hypothesized, based primarily on seed-based connectivity findings. The current results strongly support this hypothesis using whole-brain network measure in a fully data-driven approach. It remains to be seen in future studies whether these identified salience disturbances would normalize following treatment.

scholarly journals Disrupted brain network topology in chronic insomnia disorder: A resting-state fMRI study

2018 ◽  
Vol 18 ◽  
pp. 178-185 ◽  
Author(s):  
Zhonglin Li ◽  
Rui Chen ◽  
Min Guan ◽  
Enfeng Wang ◽  
Tianyi Qian ◽  
...  
Keyword(s):  
Network Topology ◽  
Resting State ◽  
Resting State Fmri ◽  
Brain Network ◽  
Chronic Insomnia ◽  
Insomnia Disorder ◽  
Fmri Study

scholarly journals Change in brain network topology as a function of treatment response in schizophrenia: a longitudinal resting-state fMRI study using graph theory

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Jennifer Ann Hadley ◽  
Nina Vanessa Kraguljac ◽  
David Matthew White ◽  
Lawrence Ver Hoef ◽  
Janell Tabora ◽  
...  
Keyword(s):  
Graph Theory ◽  
Treatment Response ◽  
Network Topology ◽  
Resting State ◽  
Resting State Fmri ◽  
Brain Network ◽  
Fmri Study

Simulating Emotional Responses in Posttraumatic Stress Disorder: An fMRI Study

2010 ◽  
Vol 3 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Richard A. Bryant ◽  
Andrew Kemp ◽  
Kim Felmingham ◽  
Belinda Liddell ◽  
Gloria Olivieri ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Emotional Responses ◽  
Fmri Study
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