scholarly journals Loss of white matter integrity in major depressive disorder: Evidence using tract-based spatial statistical analysis of diffusion tensor imaging

2010 ◽  
Vol 32 (12) ◽  
pp. 2161-2171 ◽  
Author(s):  
Mayuresh S. Korgaonkar ◽  
Stuart M. Grieve ◽  
Stephen H. Koslow ◽  
John D.E. Gabrieli ◽  
Evian Gordon ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Diffusion Tensor Imaging ◽  
Statistical Analysis ◽  
White Matter ◽  
Depressive Disorder ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
Major Depressive ◽  
Spatial Statistical Analysis

Diffusion tensor imaging predictors of treatment outcomes in major depressive disorder

2014 ◽  
Vol 205 (4) ◽  
pp. 321-328 ◽  
Author(s):  
Mayuresh S. Korgaonkar ◽  
Leanne M. Williams ◽  
Yun Ju Song ◽  
Tim Usherwood ◽  
Stuart M. Grieve
Keyword(s):  
Major Depressive Disorder ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Depressive Disorder ◽  
Diffusion Tensor ◽  
Functional Neuroimaging ◽  
Anterior Cingulate ◽  
Stria Terminalis ◽  
Major Depressive ◽  
White Matter Tracts

BackgroundFunctional neuroimaging studies implicate anterior cingulate and limbic dysfunction in major depressive disorder (MDD) and responsiveness to antidepressants. Diffusion tensor imaging (DTI) enables characterisation of white matter tracts that relate to these regions.AimsTo examine whether DTI measures of anterior cingulate and limbic white matter are useful prognostic biomarkers for MDD.MethodOf the 102 MDD out-patients from the International Study to Predict Optimized Treatment for Depression (iSPOT-D) who provided baseline magnetic resonance imaging (MRI) data, 74 completed an 8-week course of antidepressant medication (randomised to escitalopram, sertraline or extended-release venlafaxine) and were included in the present analyses. Thirty-four matched controls also provided DTI data. Fractional anisotropy was measured for five anterior cingulate–limbic white matter tracts: cingulum cingulate and hippocampus bundle, fornix, stria terminalis and uncinate fasciculus. (Trial registered at ClinicalTrials.gov: NCT00693849.)ResultsA cross-validated logistic regression model demonstrated that altered connectivity for the cingulum part of the cingulate and stria terminalis tracts significantly predicted remission independent of demographic and clinical measures with 62% accuracy. Prediction improved to 74% when age was added to this model.ConclusionsAnterior cingulate–limbic white matter is a useful predictor of antidepressant treatment outcome in MDD.

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