scholarly journals Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms

2019 ◽  
Vol Volume 15 ◽  
pp. 375-383 ◽  
Author(s):  
Shingo Kakeda ◽  
Keita Watanabe ◽  
Asuka Katsuki ◽  
Koichiro Sugimoto ◽  
Issei Ueda ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Integrity ◽  
Major Depressive ◽  
Drug Naïve ◽  
Diffusion Tensor Imaging Study

scholarly journals Association of brain white matter microstructure with cognitive performance in major depressive disorder and healthy controls: a diffusion-tensor imaging study

2021 ◽  
Author(s):  
Susanne Meinert ◽  
Nico Nowack ◽  
Dominik Grotegerd ◽  
Jonathan Repple ◽  
Nils R. Winter ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cognitive Performance ◽  
Cognitive Deficits ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Healthy Controls ◽  
Major Depressive ◽  
Diffusion Tensor Imaging Study

AbstractCognitive deficits are central attendant symptoms of major depressive disorder (MDD) with a crucial impact in patients’ everyday life. Thus, it is of particular clinical importance to understand their pathophysiology. The aim of this study was to investigate a possible relationship between brain structure and cognitive performance in MDD patients in a well-characterized sample. N = 1007 participants (NMDD = 482, healthy controls (HC): NHC = 525) were selected from the FOR2107 cohort for this diffusion-tensor imaging study employing tract-based spatial statistics. We conducted a principal component analysis (PCA) to reduce neuropsychological test results, and to discover underlying factors of cognitive performance in MDD patients. We tested the association between fractional anisotropy (FA) and diagnosis (MDD vs. HC) and cognitive performance factors. The PCA yielded a single general cognitive performance factor that differed significantly between MDD patients and HC (P < 0.001). We found a significant main effect of the general cognitive performance factor in FA (Ptfce-FWE = 0.002) in a large bilateral cluster consisting of widespread frontotemporal-association fibers. In MDD patients this effect was independent of medication intake, the presence of comorbid diagnoses, the number of previous hospitalizations, and depressive symptomatology. This study provides robust evidence that white matter disturbances and cognitive performance seem to be associated. This association was independent of diagnosis, though MDD patients show more pronounced deficits and lower FA values in the global white matter fiber structure. This suggests a more general, rather than the depression-specific neurological basis for cognitive deficits.

Age-related changes in white matter integrity: A diffusion tensor imaging study

NeuroImage ◽  
2009 ◽  
Vol 47 ◽  
pp. S128
Author(s):  
H Lemaitre ◽  
S Marenco ◽  
M Emery ◽  
T Alam ◽  
M Geramita ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Integrity ◽  
Age Related ◽  
Diffusion Tensor Imaging Study ◽  
Age Related Changes
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