The effects of combine treatment of memantine and donepezil on Alzheimer's Disease patients and its relationship with cerebral blood flow in the prefrontal area

2014 ◽  
Vol 29 (9) ◽  
pp. 881-889 ◽  
Author(s):  
Tomoko Araki ◽  
Rei Wake ◽  
Tsuyoshi Miyaoka ◽  
Kazunori Kawakami ◽  
Michiharu Nagahama ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Combine Treatment ◽  
Prefrontal Area

Hypertension Impairs Cerebral Blood Flow in a Mouse Model for Alzheimer’s Disease

2015 ◽  
Vol 12 (10) ◽  
pp. 914-922 ◽  
Author(s):  
Maximilian Wiesmann ◽  
Carmen Capone ◽  
Valerio Zerbi ◽  
Laura Mellendijk ◽  
Arend Heerschap ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Mouse Model

scholarly journals Autoregulation of Cerebral Blood Flow to Changes in Arterial Pressure in Mild Alzheimer's Disease

2010 ◽  
Vol 30 (11) ◽  
pp. 1883-1889 ◽  
Author(s):  
Allyson R Zazulia ◽  
Tom O Videen ◽  
John C Morris ◽  
William J Powers
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Pressure ◽  
The Elderly ◽  
Local Defect ◽  
Clinical Dementia Rating ◽  
Positron Emission ◽  
Before And After

Studies in transgenic mice overexpressing amyloid precursor protein (APP) demonstrate impaired autoregulation of cerebral blood flow (CBF) to changes in arterial pressure and suggest that cerebrovascular dysfunction may be critically important in the development of pathological Alzheimer's disease (AD). Given the relevance of such a finding for guiding hypertension treatment in the elderly, we assessed autoregulation in individuals with AD. Twenty persons aged 75±6 years with very mild or mild symptomatic AD (Clinical Dementia Rating 0.5 or 1.0) underwent 15O-positron emission tomography (PET) CBF measurements before and after mean arterial pressure (MAP) was lowered from 107±13 to 92±9 mm Hg with intravenous nicardipine; 11C-PIB-PET imaging and magnetic resonance imaging (MRI) were also obtained. There were no significant differences in mean CBF before and after MAP reduction in the bilateral hemispheres (−0.9±5.2 mL per 100 g per minute, P=0.4, 95% confidence interval (CI)=−3.4 to 1.5), cortical borderzones (−1.9±5.0 mL per 100 g per minute, P=0.10, 95% CI=−4.3 to 0.4), regions of T2W-MRI-defined leukoaraiosis (−0.3±4.4 mL per 100 g per minute, P=0.85, 95% CI=−3.3 to 3.9), or regions of peak 11C-PIB uptake (−2.5±7.7 mL per 100 g per minute, P=0.30, 95% CI=−7.7 to 2.7). The absence of significant change in CBF with a 10 to 15 mm Hg reduction in MAP within the normal autoregulatory range demonstrates that there is neither a generalized nor local defect of autoregulation in AD.

Regional Cerebral Blood Flow and Prognostic Evaluation in Alzheimer’s Disease

2001 ◽  
Vol 12 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Flavio Nobili ◽  
Francesco Copello ◽  
Ferdinando Buffoni ◽  
Paolo Vitali ◽  
Nicola Girtler ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Prognostic Evaluation

P4-305: IMPACT OF SIMVASTATIN ON CEREBRAL BLOOD FLOW, PULSATILITY INDEX, AND ALZHEIMER'S DISEASE BIOMARKERS: A CLINICAL TRIAL

2006 ◽  
Vol 14 (7S_Part_30) ◽  
pp. P1571-P1571
Author(s):  
Natanya S. Russek ◽  
Sara Elizabeth Berman ◽  
Karen K. Lazar ◽  
Yue Ma ◽  
Carson A. Hoffman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trial ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pulsatility Index ◽  
Disease Biomarkers ◽  
Flow Pulsatility

scholarly journals Voxel-based investigations of regional cerebral blood flow abnormalities in Alzheimer's disease using a single-detector SPECT system

Clinics ◽  
2007 ◽  
Vol 62 (4) ◽  
pp. 377-384 ◽  
Author(s):  
Fabio L. S. Duran ◽  
Fernando G. Zampieri ◽  
Cassio C.M. Bottino ◽  
Carlos A. Buchpiguel ◽  
Geraldo F. Busatto
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Single Detector ◽  
Spect System

Effects of nicergoline treatment on regional cerebral blood flow in early Alzheimer's disease

2019 ◽  
Vol 29 (3) ◽  
pp. 323-328
Author(s):  
Jooyeon J. Im ◽  
Hyeonseok Jeong ◽  
Jin Kyoung Oh ◽  
Yong‐An Chung ◽  
In‐Uk Song ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Early Alzheimer’S Disease

scholarly journals A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer’s disease

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0235691
Author(s):  
Kaja Falkenhain ◽  
Nancy E. Ruiz-Uribe ◽  
Mohammad Haft-Javaherian ◽  
Muhammad Ali ◽  
Pietro E. Michelucci ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Mouse Model ◽  
Voluntary Exercise ◽  
Model Of Alzheimer’S Disease
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