scholarly journals 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression

2009 ◽  
Vol 24 (8) ◽  
pp. 788-797 ◽  
Author(s):  
Brent P. Forester ◽  
David G. Harper ◽  
J. Eric Jensen ◽  
Caitlin Ravichandran ◽  
Brittany Jordan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
High Energy ◽  
Resonance Spectroscopy ◽  
High Energy Phosphates ◽  
Spectroscopy Study ◽  
Geriatric Depression ◽  
Tissue Specific ◽  
Magnetic Resonance Spectroscopy Study ◽  
Before And After

scholarly journals Observation of intramyocellular lipids by means of 1H magnetic resonance spectroscopy

1999 ◽  
Vol 58 (4) ◽  
pp. 841-850 ◽  
Author(s):  
Chris Boesch ◽  
Jacques Décombaz ◽  
Johannes Slotboom ◽  
Roland Kreis
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
High Energy ◽  
Muscle Physiology ◽  
High Temporal Resolution ◽  
Resonance Spectroscopy ◽  
High Energy Phosphates ◽  
Intramyocellular Lipids ◽  
Before And After ◽  
Recovery Protocols

Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are being increasingly used for investigations of human muscle physiology. While MRI reveals the morphology of muscles in great detail (e.g. for the determination of muscle volumes), MRS provides information on the chemical composition of the tissue. Depending on the observed nucleus, MRS allows the monitoring of high-energy phosphates (31P MRS), glycogen (13C MRS), or intramyocellular lipids (1H MRS), to give only a few examples. The observation of intramyocellular lipids (IMCL) by means of 1H MRS is non-invasive and, therefore, can be repeated many times and with a high temporal resolution. MRS has the potential to replace the biopsy for the monitoring of IMCL levels; however, the biopsy still has the advantage that other methods such as those used in molecular biology can be applied to the sample. The present study describes variations in the IMCL levels (expressed in mmol/kg wet weight and ml/100 ml) in three different muscles before and after (0, 1, 2, and 5 d) marathon runs for a well-trained individual who followed two different recovery protocols varying mainly in the diet. It was shown that the repletion of IMCL levels is strongly dependent on the diet post exercise. The monitoring of IMCL levels by means of 1H MRS is extremely promising, but several methodological limitations and pitfalls need to be considered, and these are addressed in the present review.

scholarly journals Effects of Traumatic Brain Injury on Cerebral High-Energy Phosphates and pH: A 31P Magnetic Resonance Spectroscopy Study

1987 ◽  
Vol 7 (5) ◽  
pp. 563-571 ◽  
Author(s):  
Robert Vink ◽  
Tracy K. McIntosh ◽  
Michael W. Weiner ◽  
Alan I. Faden
Keyword(s):  
Brain Injury ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Time Course ◽  
High Energy ◽  
Biochemical Changes ◽  
Resonance Spectroscopy ◽  
High Energy Phosphates ◽  
Magnetic Resonance Spectroscopy Study ◽  
Observation Period

Traumatic injuries to the CNS produce tissue damage both through mechanical disruption and through more delayed autodestructive processes. Delayed events include various biochemical changes whose nature and time course remain to be fully elucidated. Magnetic resonance spectroscopy (MRS) techniques permit repeated, noninvasive measurement of biochemical changes in the same animal. Using phosphorus MRS, we have examined certain biochemical responses of rats over an 8-h period following lateralized brain injury (1.5–2.5 atmospheres) using a standardized fluid-percussion model recently developed in our laboratory. Following injury, the ratio of phosphocreatine to inorganic phosphate (PCr/Pi) showed a biphasic decline: The first decline reached its nadir (4.8 ± 0.4 to 2.8 ± 0.7) by 40 min post-trauma with recovery by 100 min, followed by a second decline by 2 h that persisted for the remaining 6-h observation period (mean 2.5 ± 0.5). The first, but not the second, decrease in PCr/Pi was associated with tissue acidosis (pH 7.10 ± 0.03 to 6.86 ± 0.11). No changes in ATP occurred at any time during the injury observation period. Such changes may be indicative of altered mitochondrial energy production following brain injury, which may account for the reduced capacity of the cell to recover from traumatic injury.

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