Screening for amnestic mild cognitive impairment and early Alzheimer's disease with M@T (Memory Alteration Test) in the primary care population

2007 ◽  
Vol 22 (4) ◽  
pp. 294-304 ◽  
Author(s):  
L. Rami ◽  
J. L. Molinuevo ◽  
R. Sanchez-Valle ◽  
B. Bosch ◽  
A. Villar
Keyword(s):  
Alzheimer’S Disease ◽  
Primary Care ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Primary Care Population ◽  
Early Alzheimer’S Disease

scholarly journals Dual task performance in early Alzheimer's disease, amnestic mild cognitive impairment and depression

2008 ◽  
Vol 39 (1) ◽  
pp. 23-31 ◽  
Author(s):  
J. A. Lonie ◽  
K. M. Tierney ◽  
L. L. Herrmann ◽  
C. Donaghey ◽  
R. E. O'Carroll ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Task Performance ◽  
Dual Task ◽  
Amnestic Mild Cognitive Impairment ◽  
Dual Task Performance ◽  
Dual Task Paradigm ◽  
Early Alzheimer’S Disease

BackgroundThe dual task paradigm (Baddeleyet al.1986; Della Salaet al.1995) has been proposed as a sensitive measure of Alzheimer's dementia, early in the disease process.MethodWe investigated this claim by administering the modified dual task paradigm (utilising a pencil-and-paper version of a tracking task) to 33 patients with amnestic mild cognitive impairment (aMCI) and 10 with very early Alzheimer's disease, as well as 21 healthy elderly subjects and 17 controls with depressive symptoms. All groups were closely matched for age and pre-morbid intellectual ability.ResultsThere were no group differences in dual task performance, despite poor performance in episodic memory tests of the aMCI and early Alzheimer's disease groups. In contrast, the Alzheimer patients were specifically impaired in the trail-making test B, another commonly used test of divided attention.ConclusionsThe dual task paradigm lacks sensitivity for use in the early differential diagnosis of Alzheimer's disease.

scholarly journals Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer’s disease: A 7 Tesla MRI study

2019 ◽  
Vol 40 (4) ◽  
pp. 739-746 ◽  
Author(s):  
Willem H Bouvy ◽  
Susanne J van Veluw ◽  
Hugo J Kuijf ◽  
Jaco JM Zwanenburg ◽  
Jaap L Kappelle ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
7 Tesla ◽  
Rank Test ◽  
Amyloid Angiopathy ◽  
Perivascular Spaces ◽  
Early Alzheimer’S Disease

MRI-visible perivascular spaces (PVS) in the semioval centre are associated with cerebral amyloid angiopathy (CAA), but it is unknown if PVS co-localize with MRI markers of CAA. To examine this, we assessed the topographical association between cortical cerebral microbleeds (CMBs) – as an indirect marker of CAA – and dilatation of juxtacortical perivascular spaces (jPVS) in 46 patients with amnestic mild cognitive impairment (aMCI) or early Alzheimer’s disease (eAD). The degree of dilatation of jPVS <1 cm around each cortical CMBs was compared with a similar reference site (no CMB) in the contralateral hemisphere, using a 4-point scale. Also, jPVS dilatation was compared between patients with and without cortical CMBs. Eleven patients (24%) had cortical CMBs [total=35, median=1, range=1–14] of whom five had >1 cortical CMBs. The degree of jPVS dilatation was higher around CMBs than at the reference sites [Wilcoxon signed rank test, Z = 2.2, p = 0.03]. Patients with >1 cortical CMBs had a higher degree of jPVS dilation [median=2.2, IQR = 1.8–2.3] than patients without cortical CMBs [median=1.4, IQR = 1.0–1.8], p = 0.02. We found a topographical association between a high degree of jPVS dilatation and cortical CMBs, supporting a common underlying pathophysiology – most likely CAA.

scholarly journals Movements Execution in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

2007 ◽  
Vol 18 (3) ◽  
pp. 135-142 ◽  
Author(s):  
Rosolino Camarda ◽  
Cecilia Camarda ◽  
Roberto Monastero ◽  
Silvia Grimaldi ◽  
Lawrence K. C. Camarda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Movement Planning ◽  
Motor Dysfunction ◽  
Directed Movement ◽  
Slowing Down ◽  
Early Alzheimer’S Disease

We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer’s Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.

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