Differences in diagnostic subtypes among patients with late and early onset of a single depressive episode

2006 ◽  
Vol 21 (12) ◽  
pp. 1127-1131 ◽  
Author(s):  
Lars Vedel Kessing
Keyword(s):  
Depressive Episode ◽  
Early Onset ◽  
Single Depressive Episode

Age, Age of Onset and Course of Primary Depressive Illness in the Elderly*

1983 ◽  
Vol 28 (2) ◽  
pp. 102-104 ◽  
Author(s):  
Martin G. Cole
Keyword(s):  
Elderly Patients ◽  
Depressive Episode ◽  
Early Onset ◽  
Age Of Onset ◽  
Late Onset ◽  
The Elderly ◽  
Depressive Illness ◽  
Physical Illness ◽  
Course Of Illness

Thirty-eight elderly patients with primary depressive illness (Feighner criteria) were followed up for 7–31 months. In the absence of persistent organic signs and severe physical illness, age of onset (first depressive episode after 60) but not age was significantly related to course of illness. Compared to early onset depressives, late onset depressives were more likely to remain completely well during the follow-up period and less likely to have frequent or disabling relapses.

Gender differences in subtypes of late-onset depression and mania

2006 ◽  
Vol 18 (4) ◽  
pp. 727-738 ◽  
Author(s):  
Lars Vedel Kessing
Keyword(s):  
Health Care ◽  
Gender Differences ◽  
Bipolar Disorder ◽  
Substance Abuse ◽  
Depressive Episode ◽  
Elderly Men ◽  
Men And Women ◽  
Single Depressive Episode ◽  
First Contact ◽  
Comorbid Substance Abuse

Background: It is currently not known whether elderly men and women present with different subtypes of depression and mania/bipolar disorder. The aim of this study was to compare the prevalence of subtypes of a single depressive episode and mania/bipolar disorder according to the ICD-10 for elderly men and women in a nationwide sample of all out- and inpatients in psychiatric settings.Methods: All patients older than 65 years who received a diagnosis of a single depressive episode and mania/bipolar disorder in the period from 1994 to 2002 at the end of their first outpatient treatment or at their first discharge from psychiatric hospitalization in Denmark were identified in a nationwide register.Results: A total of 9837 patients aged more than 65 years received a diagnosis of a single depressive episode (69.9% were women) and 443 a diagnosis of mania/bipolar disorder (61.6% were women) at the end of their first contact with psychiatric health care. Slightly more women than men received a diagnosis of mild (70.8%) or moderate depression (67.4%) compared to severe depression (65.9%). Men more often presented with a single depressive episode with comorbid substance abuse or comorbid somatic illness. No gender differences were found in the prevalence of depression with or without melancholic or psychotic symptoms. Men more often presented with mania/bipolar disorder with comorbid substance abuse.Conclusions: The distributions of the subtypes of a single depressive episode or mania/bipolar disorder are remarkably similar for male and female patients aged over 65 years with first contact with the psychiatric health-care system.

scholarly journals Severity of depressive episodes during the course of depressive disorder

2008 ◽  
Vol 192 (4) ◽  
pp. 290-293 ◽  
Author(s):  
Lars Vedel Kessing
Keyword(s):  
Depressive Disorder ◽  
Depressive Episode ◽  
Prophylactic Treatment ◽  
First Episode ◽  
Case Register ◽  
Course Of Illness ◽  
Icd 10 ◽  
Single Depressive Episode ◽  
First Contact ◽  
Depressive Episodes

BackgroundIt is not clear whether the severity of depressive episodes changes during the course of depressive disorder.AimsTo investigate whether the severity of depressive episodes increases during the course of illness.MethodUsing a Danish nationwide case register, all psychiatric inpatients and out-patients with a main ICD-10 diagnosis of a single mild, moderate or severe depressive episode at the end of first contact were identified. Patients included in the study were from the period 1994–2003.ResultsA total of 19 392 patients received a diagnosis of a single depressive episode at first contact. The prevalence of severe depressive episodes increased from 25.5% at the first episode to 50.0% at the 15th episode and the prevalence of psychotic episodes increased from 8.7% at the first episode to 25.0% at the 15th episode. The same pattern was found regardless of gender, age at first contact and calendar year.ConclusionsThe increasing severity of depressive episodes emphasises the importance of early and sustained prophylactic treatment.

scholarly journals Evaluation of Platelet Glutamate Dehydrogenase Activity in Late-Life Depressions

Psychiatry ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 34-41
Author(s):  
O. K. Savushkina ◽  
E. B. Tereshkina ◽  
T. A. Prokhorova ◽  
I. S. Boksha ◽  
T. P. Safarova ◽  
...  
Keyword(s):  
Glutamate Dehydrogenase ◽  
Depressive Episode ◽  
Bipolar Affective Disorder ◽  
Late Life ◽  
Activity Level ◽  
Control Group ◽  
Late Life Depression ◽  
Before And After ◽  
Single Depressive Episode ◽  
Depressive Episodes

The aim of the study is to evaluate the activity of platelet glutamate dehydrogenase (GDH) in late-life depression compared to the healthy control group and to reveal possible correlations with clinical data. Patients and methods: 42 elderly patients (60–86 years old) with depressive episodes of different nosological categories according to ICD-10 were examined: a single depressive episode (F32.0, F32.1), a depressive episode in recurrent depressive disorder (RDD — F33.0, F33.1) and a depressive episode in bipolar affective disorder (BD — F31.3). The activity of GDH and the severity of depression (using the Hamilton depressive scale, HAMD-17, and the Hamilton scale for assessing anxiety, HARS) were evaluated twice: before the starting the course of antidepressant therapy (day 0) and on the 28th day of the treatment course. Results: patients showed a significant decrease in the activity of GDH compared to the control group (p < 0.0008). Before the treatment, GDH activity was significantly reduced compared to the control in both RDD and BD (p < 0.002 and p < 0.004), whereas after the treatment, the decreased GDH activity was observed only in patients with BD (p < 0.002). When compared with the control group, male patients showed a significant decrease in GDH activity both before and after the treatment course (p < 0.017 and p < 0.027), whereas women patients showed the decrease only before the treatment (p < 0.014). Conclusion: the decreased platelet GDH activity in elderly depressions may indicate an impairment of glutamate metabolism. Gender differences were revealed in the reversal of GDH activity level after the therapy: in men, the level of GDH activity did not recover to control values after the treatment course. An elevation in the level of GDH to control values over a 28-day course of therapy occurred only in patients with RDD, but not in patients with BD.

Gender Differences among Patients with a Single Depressive Episode

2010 ◽  
Vol 43 (3) ◽  
pp. 159-169 ◽  
Author(s):  
Jens D. Bukh ◽  
Camilla Bock ◽  
Maj Vinberg ◽  
Ulrik Gether ◽  
Lars Vedel Kessing
Keyword(s):  
Gender Differences ◽  
Depressive Episode ◽  
Single Depressive Episode

scholarly journals Validity of the diagnosis of a single depressive episode in a case register

2009 ◽  
Vol 5 (1) ◽  
pp. 4 ◽  
Author(s):  
Camilla Bock ◽  
Jens Bukh ◽  
Maj Vinberg ◽  
Ulrik Gether ◽  
Lars Kessing
Keyword(s):  
Depressive Episode ◽  
Case Register ◽  
Single Depressive Episode

scholarly journals Association of folate intake with the occurrence of depressive episodes in middle-aged French men and women

2008 ◽  
Vol 100 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Pierre Astorg ◽  
Aline Couthouis ◽  
Geneviève Potier de Courcy ◽  
Sandrine Bertrais ◽  
Nathalie Arnault ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Dietary Habits ◽  
Causal Link ◽  
Folate Intake ◽  
Recurrent Depression ◽  
Middle Aged ◽  
Men And Women ◽  
Single Depressive Episode ◽  
Depressive Episodes

A low folate intake or a low folate status have been found to be associated with a higher frequency of depression in populations, but the existence and the direction of a causal link between folate intake or status and depression is still uncertain. The aim of this study was to seek the relation between the habitual folate intake in middle-aged men and women and the occurrence of depressive episodes. In a subsample of 1864 subjects (809 men and 1055 women) from the French SU.VI.MAX cohort, dietary habits have been measured at the beginning of the follow-up (six 24 h records) and declarations of antidepressant prescription, taken as markers of depressive episodes, have been recorded during the 8-year follow-up. No significant association was observed between folate intake and the risk of any depressive episode or of a single depressive episode during the follow-up, in both men and women. In contrast, the risk of experiencing recurrent depressive episodes (two or more) during the follow-up was strongly reduced in men with high folate intake (OR 0·25 (95 % CI 0·06, 0·98) for the highest tertilev.the lowest,Pfor trend 0·046). This association was not observed in women. These results suggest that a low folate intake may increase the risk of recurrent depression in men.

scholarly journals Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

2021 ◽  
Vol 13 ◽  
Author(s):  
Niels Hansen ◽  
Aditya Singh ◽  
Claudia Bartels ◽  
Frederic Brosseron ◽  
Katharina Buerger ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Decline ◽  
Depressive Episode ◽  
Early Onset ◽  
Neural Mechanisms ◽  
Subjective Cognitive Decline ◽  
Major Depressive ◽  
Left Hippocampus ◽  
Group A ◽  
Hippocampus Volume

Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases.Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups.Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode.Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.

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