Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease

Glia ◽  
2021 ◽  
Author(s):  
Toshihiro Uesaka ◽  
Mitsumasa Okamoto ◽  
Mayumi Nagashimada ◽  
Yoshihiro Tsuda ◽  
Miho Kihara ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Mouse Models ◽  
Hirschsprung Disease ◽  
Schwann Cell Precursors

scholarly journals Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest

2017 ◽  
Vol 114 (45) ◽  
pp. 11980-11985 ◽  
Author(s):  
Isabel Espinosa-Medina ◽  
Ben Jevans ◽  
Franck Boismoreau ◽  
Zoubida Chettouh ◽  
Hideki Enomoto ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Neural Crest ◽  
Digestive Tract ◽  
Hirschsprung Disease ◽  
Enteric Neurons ◽  
Tyrosine Kinase Receptor ◽  
Neuregulin 1 ◽  
Enteric Ganglia ◽  
Schwann Cell Precursors ◽  
Dual Origin

Most of the enteric nervous system derives from the “vagal” neural crest, lying at the level of somites 1–7, which invades the digestive tract rostro-caudally from the foregut to the hindgut. Little is known about the initial phase of this colonization, which brings enteric precursors into the foregut. Here we show that the “vagal crest” subsumes two populations of enteric precursors with contrasted origins, initial modes of migration, and destinations. Crest cells adjacent to somites 1 and 2 produce Schwann cell precursors that colonize the vagus nerve, which in turn guides them into the esophagus and stomach. Crest cells adjacent to somites 3–7 belong to the crest streams contributing to sympathetic chains: they migrate ventrally, seed the sympathetic chains, and colonize the entire digestive tract thence. Accordingly, enteric ganglia, like sympathetic ones, are atrophic when deprived of signaling through the tyrosine kinase receptor ErbB3, while half of the esophageal ganglia require, like parasympathetic ones, the nerve-associated form of the ErbB3 ligand, Neuregulin-1. These dependencies might bear relevance to Hirschsprung disease, with which alleles of Neuregulin-1 are associated.

scholarly journals Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

2021 ◽  
Author(s):  
Marketa Kaucka ◽  
Bara Szarowska ◽  
Michaela Kavkova ◽  
Maria Eleni Kastriti ◽  
Polina Kameneva ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Inner Ear ◽  
Gene Knockout ◽  
Hair Follicles ◽  
Lineage Tracing ◽  
Pigment Cells ◽  
Hearing Function ◽  
Embryonic Origin ◽  
Schwann Cell Precursors ◽  
Evolutionary Aspects

AbstractMelanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans.

Schwann cell precursors generate sympathoadrenal system during zebrafish development

2021 ◽  
Author(s):  
Dmitrii Kamenev ◽  
Kazunori Sunadome ◽  
Maxim Shirokov ◽  
Andrey S. Chagin ◽  
Ajeet Singh ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Sympathoadrenal System ◽  
Zebrafish Development ◽  
Schwann Cell Precursors

Schwann cell precursors and their development

Glia ◽  
1991 ◽  
Vol 4 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Kristjan R. Jessen ◽  
Rhona Mirsky
Keyword(s):  
Schwann Cell ◽  
Schwann Cell Precursors

scholarly journals Directly induced human Schwann cell precursors as a valuable source of Schwann cells

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Han-Seop Kim ◽  
Jae Yun Kim ◽  
Cho Lok Song ◽  
Ji Eun Jeong ◽  
Yee Sook Cho
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Valuable Source ◽  
Schwann Cell Precursors

scholarly journals Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip

2016 ◽  
Vol 19 (4) ◽  
pp. 433-448 ◽  
Author(s):  
Adam P.W. Johnston ◽  
Scott A. Yuzwa ◽  
Matthew J. Carr ◽  
Neemat Mahmud ◽  
Mekayla A. Storer ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Paracrine Factors ◽  
Schwann Cell Precursors

Schwann cell precursors in health and disease

Glia ◽  
2017 ◽  
Vol 66 (3) ◽  
pp. 465-476 ◽  
Author(s):  
Jorge B. Aquino ◽  
Romina Sierra
Keyword(s):  
Schwann Cell ◽  
Health And Disease ◽  
Schwann Cell Precursors
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