scholarly journals Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip

2016 ◽  
Vol 19 (4) ◽  
pp. 433-448 ◽  
Author(s):  
Adam P.W. Johnston ◽  
Scott A. Yuzwa ◽  
Matthew J. Carr ◽  
Neemat Mahmud ◽  
Mekayla A. Storer ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Paracrine Factors ◽  
Schwann Cell Precursors

scholarly journals Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

2021 ◽  
Author(s):  
Marketa Kaucka ◽  
Bara Szarowska ◽  
Michaela Kavkova ◽  
Maria Eleni Kastriti ◽  
Polina Kameneva ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Inner Ear ◽  
Gene Knockout ◽  
Hair Follicles ◽  
Lineage Tracing ◽  
Pigment Cells ◽  
Hearing Function ◽  
Embryonic Origin ◽  
Schwann Cell Precursors ◽  
Evolutionary Aspects

AbstractMelanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans.

Schwann cell precursors generate sympathoadrenal system during zebrafish development

2021 ◽  
Author(s):  
Dmitrii Kamenev ◽  
Kazunori Sunadome ◽  
Maxim Shirokov ◽  
Andrey S. Chagin ◽  
Ajeet Singh ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Sympathoadrenal System ◽  
Zebrafish Development ◽  
Schwann Cell Precursors

Schwann cell precursors and their development

Glia ◽  
1991 ◽  
Vol 4 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Kristjan R. Jessen ◽  
Rhona Mirsky
Keyword(s):  
Schwann Cell ◽  
Schwann Cell Precursors

scholarly journals Directly induced human Schwann cell precursors as a valuable source of Schwann cells

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Han-Seop Kim ◽  
Jae Yun Kim ◽  
Cho Lok Song ◽  
Ji Eun Jeong ◽  
Yee Sook Cho
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Valuable Source ◽  
Schwann Cell Precursors

Schwann cell precursors in health and disease

Glia ◽  
2017 ◽  
Vol 66 (3) ◽  
pp. 465-476 ◽  
Author(s):  
Jorge B. Aquino ◽  
Romina Sierra
Keyword(s):  
Schwann Cell ◽  
Health And Disease ◽  
Schwann Cell Precursors
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