scholarly journals SSEA ‐4 and YKL ‐40 positive progenitor subtypes in the subventricular zone of developing human neocortex

Glia ◽  
2015 ◽  
Vol 64 (1) ◽  
pp. 90-104 ◽  
Author(s):  
Christian B. Brøchner ◽  
Kjeld Møllgård
Keyword(s):  
Subventricular Zone ◽  
Human Neocortex

Neurogenic radial glia in the outer subventricular zone of human neocortex

Nature ◽  
2010 ◽  
Vol 464 (7288) ◽  
pp. 554-561 ◽  
Author(s):  
David V. Hansen ◽  
Jan H. Lui ◽  
Philip R. L. Parker ◽  
Arnold R. Kriegstein
Keyword(s):  
Subventricular Zone ◽  
Radial Glia ◽  
Human Neocortex

scholarly journals Is Forebrain Neurogenesis a Potential Repair Mechanism after Stroke?

2015 ◽  
Vol 35 (7) ◽  
pp. 1220-1221 ◽  
Author(s):  
agos Inta ◽  
Peter Gass
Keyword(s):  
Adult Neurogenesis ◽  
Broad Spectrum ◽  
Subventricular Zone ◽  
Genetic Manipulation ◽  
Gabaergic Interneurons ◽  
Repair Mechanism ◽  
Brain Repair ◽  
Human Neocortex ◽  
Repair Strategy ◽  
Adult Human

The use of adult subventricular zone (SVZ) neurogenesis as brain repair strategy after stroke represents a hot topic in neurologic research. Recent radiocarbon-14 dating has revealed a lack of poststroke neurogenesis in the adult human neocortex; however, adult neurogenesis has been shown to occur, even under physiologic conditions, in the human striatum. Here, these results are contrasted with experimental poststroke neurogenesis in the murine brain. Both in humans and in rodents, the SVZ generates predominantly calretinin (CR)-expressing GABAergic interneurons, which cannot replace the broad spectrum of neuronal subtypes damaged by stroke. Therefore, SVZ neurogenesis may represent a repair mechanism only after genetic manipulation redirecting its differentiation.

Improved Stage Categorization of PTZ-Induced Kindling and Late Enhanced Neurogenesis in PTZ Kindled Mice

2019 ◽  
Vol 8 ◽  
pp. 1511
Author(s):  
Marzieh Shahpari ◽  
Hadi Aligholi ◽  
Mohammad Reza Namavar ◽  
Farzaneh Vafaee ◽  
Masoumeh Emamghoreishi
Keyword(s):  
Subventricular Zone ◽  
Early Phase ◽  
Hind Limb ◽  
Late Phase ◽  
The Other ◽  
Myoclonic Jerk ◽  
Ptz Kindling ◽  
First Occurrence ◽  
Tonic Extension ◽  
Behavioral Index

Background: There is no universally accepted behavioral scoring to define the early development of phenothiazine (PTZ) kindling. Therefore, studies investigating alterations of neurogenesis in the PTZ model were mainly focused on full kindled animals rather than early stages of kindling. This study aimed to determine an appropriate behavioral index for categorizing stages of PTZ kindling progress and to evaluate neurogenesis during PTZ kindling. Materials and Methods: Twenty-four mice were intraperitoneally injected with a sub convulsive dose of PTZ (40mg/kg) every other day until they became full kindled. The first occurrence of different seizure behaviors and their durations were recorded during kindling development, and the different stages of kindling were categorized. Neurogenesis was evaluated in the lateral subventricular zone (SVZ) at each stage of kindling by immunofluorescence staining. Results: First occurrence of restlessness, motionless staring, hind limb tonic extension, Straub’s tail, myoclonic jerk, and tonic-clonic were sequentially observed in more than 80% of animals with increasing PTZ injections. The duration of the myoclonic jerk was significantly longer than the other seizure behaviors. The significantly higher percentage of BrdU-positive cells was found in SVZ of mice showing tonic-clonic in comparison to other seizure behaviors. Conclusion: A hierarchy behavior was observed during the kindling process when considering the first occurrence of seizure behaviors. We defined the first occurrence of restlessness, motionless, hind limb tonic extension and Straub’s tail behaviors as an early phase, myoclonic jerk as a borderline phase and tonic-clonic as a late phase of PTZ-induced kindling. Our results indicated an enhanced SVZ neurogenesis at the late phase of kindling. [GMJ.2019;8:e1511]

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