scholarly journals Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice

Glia ◽  
2015 ◽  
Vol 63 (10) ◽  
pp. 1860-1869 ◽  
Author(s):  
Xiaoming Yao ◽  
Alex J. Smith ◽  
Byung-Ju Jin ◽  
Zsolt Zador ◽  
Geoffrey T. Manley ◽  
...  
Keyword(s):  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Aquaporin 4

scholarly journals Aquaporin‐4‐independent volume dynamics of astroglial endfeet during cortical spreading depression

Glia ◽  
2019 ◽  
Vol 67 (6) ◽  
pp. 1113-1121 ◽  
Author(s):  
Brana Rosic ◽  
Didrik B. Dukefoss ◽  
Knut Sindre Åbjørsbråten ◽  
Wannan Tang ◽  
Vidar Jensen ◽  
...  
Keyword(s):  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Aquaporin 4

scholarly journals Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice

2016 ◽  
Vol 27 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Rune Enger ◽  
Didrik B. Dukefoss ◽  
Wannan Tang ◽  
Klas H. Pettersen ◽  
Daniel M. Bjørnstad ◽  
...  
Keyword(s):  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Aquaporin 4 ◽  
Extracellular Glutamate

scholarly journals In Vivo NADH Fluorescence Imaging Indicates Effect of Aquaporin-4 Deletion on Oxygen Microdistribution in Cortical Spreading Depression

2013 ◽  
Vol 33 (7) ◽  
pp. 996-999 ◽  
Author(s):  
Alexander S Thrane ◽  
Takahiro Takano ◽  
Vinita Rangroo Thrane ◽  
Fushun Wang ◽  
Weiguo Peng ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Fluorescence Imaging ◽  
Nicotinamide Adenine Dinucleotide ◽  
Oxygen Delivery ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Aquaporin 4 ◽  
Two Photon ◽  
Nadh Fluorescence

Using in vivo two-photon imaging, we show that mice deficient in aquaporin-4 (AQP4) display increased fluorescence of nicotinamide adenine dinucleotide (NADH) when subjected to cortical spreading depression. The increased NADH signal, a proxy of tissue hypoxia, was restricted to microwatershed areas remote from the vasculature. Aqp4 deletion had no effects on the hyperemia response, but slowed [K+]o recovery. These observations suggest that K+ uptake is suppressed in Aqp4−/- mice as a consequence of decreased oxygen delivery to tissue located furthest away from the vascular source of oxygen, although increased oxygen consumption may also contribute to our observations.

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