Purines regulate adult brain subventricular zone cell functions: Contribution of reactive astrocytes

Glia ◽  
2013 ◽  
Vol 62 (3) ◽  
pp. 428-439 ◽  
Author(s):  
Marta Boccazzi ◽  
Chiara Rolando ◽  
Maria P. Abbracchio ◽  
Annalisa Buffo ◽  
Stefania Ceruti
Keyword(s):  
Subventricular Zone ◽  
Reactive Astrocytes ◽  
Adult Brain ◽  
Cell Functions ◽  
Zone Cell

Galanin Promotes Neuronal Differentiation in Murine Subventricular Zone Cell Cultures

2013 ◽  
Vol 22 (11) ◽  
pp. 1693-1708 ◽  
Author(s):  
Fabienne Agasse ◽  
Sara Xapelli ◽  
Valérie Coronas ◽  
Søren H. Christiansen ◽  
Alexandra I. Rosa ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Cell Cultures ◽  
Subventricular Zone ◽  
Zone Cell

scholarly journals Lineage progression from stem cells to new neurons in the adult brain ventricular-subventricular zone

Cell Cycle ◽  
2013 ◽  
Vol 12 (11) ◽  
pp. 1649-1650 ◽  
Author(s):  
Giovanna Ponti ◽  
Kirsten Obernier ◽  
Arturo Alvarez-Buylla
Keyword(s):  
Stem Cells ◽  
Subventricular Zone ◽  
Adult Brain

NFIX-Mediated Inhibition of Neuroblast Branching Regulates Migration Within the Adult Mouse Ventricular–Subventricular Zone

2018 ◽  
Vol 29 (8) ◽  
pp. 3590-3604 ◽  
Author(s):  
Oressia Zalucki ◽  
Lachlan Harris ◽  
Tracey J Harvey ◽  
Danyon Harkins ◽  
Jocelyn Widagdo ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Subventricular Zone ◽  
Adult Mouse ◽  
Adult Brain ◽  
Granule Cell Layer ◽  
Transcriptional Level ◽  
Olfactory Responses ◽  
Brain Functions ◽  
Neuroblast Migration ◽  
Adult Mice

Abstract Understanding the migration of newborn neurons within the brain presents a major challenge in contemporary biology. Neuronal migration is widespread within the developing brain but is also important within the adult brain. For instance, stem cells within the ventricular–subventricular zone (V-SVZ) and the subgranular zone of dentate gyrus of the adult rodent brain produce neuroblasts that migrate to the olfactory bulb and granule cell layer of the dentate gyrus, respectively, where they regulate key brain functions including innate olfactory responses, learning, and memory. Critically, our understanding of the factors mediating neuroblast migration remains limited. The transcription factor nuclear factor I X (NFIX) has previously been implicated in embryonic cortical development. Here, we employed conditional ablation of Nfix from the adult mouse brain and demonstrated that the removal of this gene from either neural stem and progenitor cells, or neuroblasts, within the V-SVZ culminated in neuroblast migration defects. Mechanistically, we identified aberrant neuroblast branching, due in part to increased expression of the guanylyl cyclase natriuretic peptide receptor 2 (Npr2), as a factor contributing to abnormal migration in Nfix-deficient adult mice. Collectively, these data provide new insights into how neuroblast migration is regulated at a transcriptional level within the adult brain.

scholarly journals Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63529 ◽  
Author(s):  
Sara Xapelli ◽  
Fabienne Agasse ◽  
Laura Sardà-Arroyo ◽  
Liliana Bernardino ◽  
Tiago Santos ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Subventricular Zone ◽  
Cannabinoid Receptor ◽  
Zone Cell ◽  
Type 1 Cannabinoid Receptor

scholarly journals Role of laminin bioavailability in the astroglial permissivity for neuritic outgrowth

2002 ◽  
Vol 74 (4) ◽  
pp. 683-690 ◽  
Author(s):  
MARCIENNE TARDY
Keyword(s):  
Glial Fibrillary Acidic Protein ◽  
Neurite Outgrowth ◽  
Axonal Regeneration ◽  
Glial Scar ◽  
Reactive Astrocytes ◽  
Adult Brain ◽  
Morphological Response ◽  
Phenotypic Changes ◽  
Neuritic Outgrowth

The mechanisms involved in the failure of an adult brain to regenerate post-lesion remain poorly understood. The reactive gliosis which occurs after an injury to the CNS and leads to the glial scar has been considered as one of the major impediments to neurite outgrowth and axonal regeneration. A glial scar consists mainly of reactive, hypertrophic astrocytes. These reactive cells acquire new properties, leading to A non-permissive support for neurons. Astrogial reactivity is mainly characteriized by a high overexpression of the major component of the gliofilaments, the glial fibrillary acidic protein (GFAP). This GFAP overexpression is related to the astroglial morphological response to injury. We hypothesized that modulation of GFAP synthesis, reversing the hypertrophic phenotype, might also reverse the blockage of neuritic outgrowth observed after a lesion. In this article, we review findings of our group, confirming our hypothesis in a model of lesioned neuron-astrocyte cocultures. We demonstrate that permissivity for neuritic outgrowth is related to phenotypic changes induced in reactive astrocytes transfected by antisense GFAP-mRNA. We also found that this permissivity was related to a neuron-regulated extracellular laminin bioavailability.

Sign in / Sign up

Export Citation Format

Share Document