scholarly journals Emerging roles of p53 in glial cell function in health and disease

Glia ◽  
2011 ◽  
Vol 60 (4) ◽  
pp. 515-525 ◽  
Author(s):  
Joseph D. Jebelli ◽  
Claudie Hooper ◽  
Gwenn A. Garden ◽  
Jennifer M. Pocock
Keyword(s):  
Glial Cell ◽  
Cell Function ◽  
Health And Disease

2. Europäische Tagung: “Glial Cell Function in Health and Disease”

e-Neuroforum ◽  
1996 ◽  
Vol 2 (3) ◽  
Author(s):  
Gerald Seifert ◽  
Christian Steinhäuser
Keyword(s):  
Glial Cell ◽  
Cell Function ◽  
Health And Disease

scholarly journals Thyroid Hormone and the Neuroglia: Both Source and Target

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Petra Mohácsik ◽  
Anikó Zeöld ◽  
Antonio C. Bianco ◽  
Balázs Gereben
Keyword(s):  
Thyroid Hormone ◽  
Cell Function ◽  
Hormone Regulation ◽  
Mediobasal Hypothalamus ◽  
Iodothyronine Deiodinase ◽  
Neuronal Gene ◽  
Health And Disease ◽  
And Function ◽  
The Brain

Thyroid hormone plays a crucial role in the development and function of the nervous system. In order to bind to its nuclear receptor and regulate gene transcription thyroxine needs to be activated in the brain. This activation occurs via conversion of thyroxine to T3, which is catalyzed by the type 2 iodothyronine deiodinase (D2) in glial cells, in astrocytes, and tanycytes in the mediobasal hypothalamus. We discuss how thyroid hormone affects glial cell function followed by an overview on the fine-tuned regulation of T3 generation by D2 in different glial subtypes. Recent evidence on the direct paracrine impact of glial D2 on neuronal gene expression underlines the importance of glial-neuronal interaction in thyroid hormone regulation as a major regulatory pathway in the brain in health and disease.

Aging-dependent changes of glial cell function and Alzheimer’s disease

2015 ◽  
Vol 357 ◽  
pp. e511
Author(s):  
R. von Bernhardi ◽  
F. Cornejo ◽  
L. Eugenín-von Bernhardi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glial Cell ◽  
Cell Function
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