Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury

Glia ◽  
2011 ◽  
Vol 59 (6) ◽  
pp. 869-881 ◽  
Author(s):  
Christiane Simon ◽  
Magdalena Götz ◽  
Leda Dimou
Keyword(s):  
Cell Cycle ◽  
Cerebral Cortex ◽  
Cortex Cell

scholarly journals Author Correction: Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Corinne L. A. Fairchild ◽  
Simranjeet K. Cheema ◽  
Joanna Wong ◽  
Keiko Hino ◽  
Sergi Simó ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cerebral Cortex ◽  
Cell Cycle Dynamics

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals Mouse (Mus musculus) embryonic cerebral cortex cell death caused by carbofuran insecticide exposure

2019 ◽  
Vol 63 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Epy Muhammad Luqman ◽  
I Ketut Sudiana ◽  
Win Darmanto ◽  
Agung Budianto Achmad ◽  
Widjiati
Keyword(s):  
Cerebral Cortex ◽  
Caspase 3 ◽  
High Dose ◽  
Intrinsic Pathway ◽  
Neuron Death ◽  
Sod Activity ◽  
Insecticide Exposure ◽  
Cortex Cell ◽  
Cerebral Cortical Neuron ◽  
Increased Activity

Abstract Introduction The aim of the study was to describe the process of neuron death in the cerebral cortex caused by embryonic carbofuran exposure. Material and Methods 81 mouse foetuses from 27 breeding mice were used in the study. Carbofuran was administered by gavage from the 6th to the 15th day of gestation to two groups: one at 0.0208 and the other at 0.0417 mg/kg b.w. On the 17th day, the mice were sacrificed and the foetuses were taken to measure the ROS (malondialdehyde/MDA and superoxide dismutase/SOD) activity in brain tissue, the number of apoptotic embryonic cerebral cortex neurons using a TUNEL assay, and necrotic cells using HE staining. Examination of p53 and caspase 3 expression was done by immunohistochemistry. Data were analysed using analysis of variance (ANOVA) and Duncan’s test. Results Increased activity of cerebral ROS characterised by significant elevation of the MDA level (P < 0.05), decreased SOD (P < 0.01), increased p53 and caspase 3 expression, and cerebral cortical neuron death either by necrosis or apoptosis (P < 0.05) were found. At the low dose carbofuran increased expression of p53, caspase 3, and apoptosis. At the high dose it increased levels of MDA and necrosis. Conclusion Increased expression of p53 and caspase 3 and apoptosis indicated that carbofuran may cause apoptosis through the intrinsic pathway. The increased apoptosis grants an opportunity to prevent and treat the effect of ROS due to gestational carbofuran exposure.

scholarly journals p57KIP2 regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex

Development ◽  
2012 ◽  
Vol 139 (3) ◽  
pp. 475-487 ◽  
Author(s):  
G. Mairet-Coello ◽  
A. Tury ◽  
E. Van Buskirk ◽  
K. Robinson ◽  
M. Genestine ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cerebral Cortex ◽  
Radial Glia ◽  
Lower Layer ◽  
Precursor Cell ◽  
Cell Cycle Dynamics
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