scholarly journals Developmental changes in interkinetic nuclear migration dynamics with respect to cell‐cycle progression in the mouse cerebral cortex ventricular zone

2019 ◽  
Vol 527 (10) ◽  
pp. 1545-1557 ◽  
Author(s):  
Julie Fousse ◽  
Elodie Gautier ◽  
Dorothée Patti ◽  
Colette Dehay
Keyword(s):  
Cell Cycle ◽  
Cerebral Cortex ◽  
Cell Cycle Progression ◽  
Ventricular Zone ◽  
Nuclear Migration ◽  
Developmental Changes ◽  
Cycle Progression ◽  
Interkinetic Nuclear Migration ◽  
Mouse Cerebral Cortex ◽  
Migration Dynamics

Cell cycle progression is required for nuclear migration of neural progenitor cells

2006 ◽  
Vol 1088 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Masaki Ueno ◽  
Kei-ichi Katayama ◽  
Hirofumi Yamauchi ◽  
Hiroyuki Nakayama ◽  
Kunio Doi
Keyword(s):  
Cell Cycle ◽  
Progenitor Cells ◽  
Cell Cycle Progression ◽  
Neural Progenitor Cells ◽  
Nuclear Migration ◽  
Neural Progenitor ◽  
Cycle Progression

scholarly journals Zfp423, a Joubert syndrome gene, is a domain-specific regulator of cell cycle progression, DNA damage response and Purkinje cell development in the cerebellar primordium

2017 ◽  
Author(s):  
Filippo Casonil ◽  
Laura Crocil ◽  
Camilla Bosonel ◽  
Roberta D’Ambrosio ◽  
Aurora Badaloni ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Neural Development ◽  
Cell Cycle Progression ◽  
Ventricular Zone ◽  
Joubert Syndrome ◽  
Cycle Progression ◽  
Domain Specific ◽  
Damage Response

ABSTRACTNeurogenesis is a tightly regulated process whose success depends on the ability to balance the expansion/maintenance of an undifferentiated neural progenitor pool with the precisely timed birth of sequential generations of neurons. The Zfp423 gene encodes a 30-Zn-finger transcription factor (TF) that acts as a scaffold in the assembly of complex transcriptional and cellular machineries regulating neural development. While null mutants for Zfp423 feature a severe cerebellar hypoplasia, the underlying mechanism is only partially characterized. Mutations of the human ortholog ZNF423 have been identified in patients carrying cerebellar vermis hypoplasia (CVH) or Joubert Syndrome (JS), associated with other signs of classical ciliopathy outside the central nervous system (CNS). ZNF423 also plays a role in the DNA damage response (DDR). To further characterize the role of ZFP423 in cerebellar neurogenesis, with a focus on Purkinje cells (PC) development, we analyzed two previously undescribed mutant mouse lines carrying allelic in-frame deletions of the corresponding gene, selectively affecting two functionally characterized protein-protein interaction domains, affecting zinc (Zn) fingers 9-20 or 28-30. Some phenotypic defects are allele specific: Zfp423Δ9-20/Δ9-20 mutants exhibit a depletion of the OLIG2+ PC progenitor pool in the cerebellar ventricular zone (VZ). In these mutants, M-phase progenitors display changes in spindle orientation indicative of a precocious switch from symmetric to asymmetric cell division. Conversely, the Zfp423Δ28-30/Δ28-30 primordium displays a sharp decrease in the expression of PC differentiation markers, including CORL2, despite an abundance of cycling PC progenitors. Moreover, and importantly, in both mutants VZ progenitor cell cycle progression is remarkably affected, and factors involved in the DDR are substantially upregulated in the VZ and in postmitotic precursors alike. Our in vivo evidence sheds light on the domain-specific roles played by ZFP423 in different aspects of PC progenitor development, and at the same time supports the emerging notion that an impaired DNA damage response may be a key factor in the pathogenesis of JS and other ciliopathies.

scholarly journals OTX1 regulates cell cycle progression of neural progenitors in the developing cerebral cortex

2017 ◽  
Vol 293 (6) ◽  
pp. 2137-2148 ◽  
Author(s):  
Baoshan Huang ◽  
Xue Li ◽  
Xiaomeng Tu ◽  
Wei Zhao ◽  
Dan Zhu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cerebral Cortex ◽  
Cell Cycle Progression ◽  
Neural Progenitors ◽  
Cycle Progression
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