In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head

Glia ◽  
2001 ◽  
Vol 34 (3) ◽  
pp. 178-189 ◽  
Author(s):  
G�lg�n Tezel ◽  
M. Rosario Hernandez ◽  
Martin B. Wax
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Tissue Remodeling ◽  
Reactive Astrocyte ◽  
In Vitro Evaluation

Responses and signaling pathways in human optic nerve head astrocytes exposed to hydrostatic pressure in vitro

Glia ◽  
2004 ◽  
Vol 45 (4) ◽  
pp. 364-377 ◽  
Author(s):  
Mercedes Salvador-Silva ◽  
Shun Aoi ◽  
Amy Parker ◽  
Ping Yang ◽  
Paula Pecen ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Hydrostatic Pressure ◽  
Signaling Pathways ◽  
Optic Nerve Head ◽  
Human Optic Nerve

scholarly journals Integrins in Trabecular Meshwork and Optic Nerve Head: Possible Association with the Pathogenesis of Glaucoma

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yisheng Zhong ◽  
Jing Wang ◽  
Xunda Luo
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Trabecular Meshwork ◽  
Intracellular Signaling ◽  
Open Angle Glaucoma ◽  
Glaucomatous Optic Neuropathy ◽  
Stress And Strain ◽  
Membrane Spanning

Integrins are a family of membrane-spanning proteins that are important receptors for cell adhesion to extracellular matrix proteins. They also provide connections between the extracellular environment and intracellular cytoskeletons and are responsible for activation of many intracellular signaling pathways. In vitro and in vivo data strongly indicate that integrin-mediated signaling events can modulate the organization of the actin cytoskeleton in trabecular meshwork (TM) cells and are associated with astrocyte migration and microglia activation of the optic nerve head in patients with primary open angle glaucoma. Consequently, increase in resistance in the TM outflow pathways and remodeling of the optic nerve head occur, which in turn increases intraocular pressure (IOP), adds additional mechanical stress and strain to optic nerve axons, and accelerates damage of axons initially caused by optic nerve head remodeling. Integrins appear to be ideal candidates for translating physical stress and strain into cellular responses known to occur in glaucomatous optic neuropathy.

In vitro evaluation of IL-18 effects in Crohn's disease

2001 ◽  
Vol 120 (5) ◽  
pp. A316-A317
Author(s):  
P MAERTEN ◽  
S COLPAERT ◽  
Z LIU ◽  
K GEBOES ◽  
J CEUPPENS ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
In Vitro Evaluation

52: In Vitro Evaluation of Ureteral Stent Compression

2006 ◽  
Vol 175 (4S) ◽  
pp. 18-18
Author(s):  
Kari Hendlin ◽  
Krishna Vedula ◽  
Christina Horn ◽  
Manoj Monga
Keyword(s):  
Ureteral Stent ◽  
In Vitro Evaluation
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