scholarly journals Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies

2009 ◽  
Vol 34 (2) ◽  
pp. 107-118 ◽  
Author(s):  
Yun J. Yoo ◽  
Shelley B. Bull ◽  
Andrew D. Paterson ◽  
Daryl Waggott ◽  
Lei Sun
Keyword(s):  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Linkage Studies ◽  
Genome Wide ◽  
Candidate Regions

The Australian Twin Registry as a Resource For Genetic Studies into Ophthalmic Traits

2012 ◽  
Vol 16 (1) ◽  
pp. 52-57
Author(s):  
Maria Schache ◽  
Paul N. Baird
Keyword(s):  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Linkage Studies ◽  
Genetic Studies ◽  
For Profit ◽  
Not For Profit ◽  
Twin Registry ◽  
Genome Wide ◽  
Broad Overview

The Australian Twin Registry (ATR) is a not-for-profit organization that coordinates research involving Australian twins and researchers. The ATR is one of the largest volunteer registries of its kind and contains over 33,000 twin pairs. The purpose of this review is to provide a broad overview of recent ophthalmic studies that have utilized the ATR for recruitment purposes. Such studies include the Australian Twin Eye Study (ATES) and the Genes in Myopia (GEM) study. The ATES and GEM studies have undertaken studies into the genetic influences on a number of ophthalmic traits through the use of heritability studies, linkage studies, genome-wide association studies, and candidate gene-based studies. An overview of these studies is provided in this review, as well as a description of the recruitment methodologies for both the ATES and GEM studies.

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