scholarly journals Synthesis, Characterization, and Flocculation Studies of β‐Cyclodextrin‐Based Stimuli‐Responsive Star Copolymer: An Environmental Remediation

2020 ◽  
Vol 4 (7) ◽  
pp. 1900089 ◽  
Author(s):  
Kiran ◽  
Rambabu Koyilapu ◽  
Rudramani Tiwari ◽  
Subramanian Krishnamoorthi ◽  
Krishna Kumar
Keyword(s):  
Environmental Remediation ◽  
Stimuli Responsive ◽  
Star Copolymer

scholarly journals Dragonfly Inspired Smart Soft Robot

2020 ◽  
Author(s):  
Vardhman Kumar ◽  
Ung Hyun Ko ◽  
Yilong Zhou ◽  
Jiaul Hoque ◽  
Gaurav Arya ◽  
...  
Keyword(s):  
Environmental Remediation ◽  
Stimuli Responsive ◽  
Complex Environments ◽  
Soft Robots ◽  
Responsive Materials ◽  
Environmental Perturbations ◽  
Integration Strategies ◽  
Soft Actuators ◽  
Harsh Conditions

Recent advancements in soft robotics have led to the development of compliant robots that can exhibit complex motions driven by living cells(1, 2), chemical reactions(3), or electronics(4). Further innovations are however needed to create the next generation of soft robots that can carry out advanced functions beyond locomotion. Here we describe DraBot—a dragonfly-inspired, entirely soft, multifunctional robot that combines long-term locomotion over water surface with sensing, responding, and adaptation capabilities. By integrating soft actuators, stimuli-responsive materials, and microarchitectural features, we created a circuitry of pneumatic and microfluidic logic that enabled the robot to undergo user- and environment-controlled (pH) locomotion, including navigating hazardous (acidic) conditions. DraBot was also engineered to sense additional environmental perturbations (temperature) and detect and clean up chemicals (oil). The design, fabrication, and integration strategies demonstrated here pave a way for developing futuristic soft robots that can acclimatize and adapt to harsh conditions while carrying out complex tasks such as exploration, environmental remediation, and health care in complex environments.

Unconventional and facile production of stimuli-responsive multifunctional system for simultaneous drug delivery and environmental remediation

2021 ◽  
Author(s):  
Narsimha Mamidi ◽  
Ramiro Manuel Velasco Delgadillo ◽  
Javier Villela Castrejón
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Environmental Remediation ◽  
Single Walled Carbon Nanotubes ◽  
Selective Removal ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Single Walled Carbon ◽  
Fiber Membranes ◽  
Walled Carbon Nanotubes

Herein, pH-responsive poly 4-hydroxyphenyl methacrylated single-walled carbon nanotubes (PHPMA-SWCNT = f-CNT)/PE nanocomposite (NCST) fiber membranes were developed for stimuli drug delivery and the selective removal of Pb2+ and Cd2+ from...

scholarly journals pH/Reduction Dual-Stimuli-Responsive Cross-Linked Micelles Based on Multi-Functional Amphiphilic Star Copolymer: Synthesis and Controlled Anti-Cancer Drug Release

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 82 ◽  
Author(s):  
Yunwei Huang ◽  
Jingye Yan ◽  
Shiyuan Peng ◽  
Zilun Tang ◽  
Cuiying Tan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Thermodynamic Analysis ◽  
Electrostatic Interaction ◽  
Cancer Drug ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Star Copolymer

Novel approach has been constructed for preparing the amphiphilic star copolymer pH/reduction stimuli-responsive cross-linked micelles (SCMs) as a smart drug delivery system for the well-controlled anti-tumor drug doxorubicin (DOX) release. The SCMs had a low CMC value of 5.3 mg/L. The blank and DOX-loaded SCMs both had a spherical shape with sizes around 100–180 nm. In addition, the good stability and well pH/reduction-sensitivity of the SCMs were determined by dynamic light scattering (DLS) as well. The SCMs owned a low release of DOX in bloodstream and normal tissues while it had a fast release in tumor higher glutathione (GSH) concentration and/or lower pH value conditions, which demonstrates their pH/reduction dual-responsiveness. Furthermore, we conducted the thermodynamic analysis to study the interactions between the DOX and polymer micelles in the DOX release process. The values of the thermodynamic parameters at pH 7.4 and at pH 5.0 conditions indicated that the DOX release was endothermic and controlled mainly by the forces of an electrostatic interaction. At pH 5.0 with 10 mM GSH condition, electrostatic interaction, chemical bond, and hydrophobic interactions contributed together on DOX release. With the low cytotoxicity of blank SCMs and well cytotoxicity of DOX-loaded SCMs, the results indicated that the SCMs could form a smart cancer microenvironment-responsive drug delivery system. The release kinetic and thermodynamic analysis offer a theoretical foundation for the interaction between drug molecules and polymer matrices, which helps provide a roadmap for the oriented design and control of anti-cancer drug release for cancer therapy.

Amphiphilic Glycopolypeptide Star Copolymer-Based Cross-Linked Nanocarriers for Targeted and Dual-Stimuli-Responsive Drug Delivery

2018 ◽  
Vol 30 (3) ◽  
pp. 633-646 ◽  
Author(s):  
Bhawana Pandey ◽  
Naganath G. Patil ◽  
Govind S. Bhosle ◽  
Ashootosh V. Ambade ◽  
Sayam Sen Gupta
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
Star Copolymer

scholarly journals Recently Developed Carbohydrate Based Gelators and Their Applications

Gels ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 24
Author(s):  
Joedian Morris ◽  
Jonathan Bietsch ◽  
Kristen Bashaw ◽  
Guijun Wang
Keyword(s):  
Molecular Weight ◽  
Environmental Remediation ◽  
Rational Design ◽  
Materials Science ◽  
Structural Features ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Ion Sensing ◽  
Self Assembling ◽  
Low Molecular Weight Gelators

Carbohydrate based low molecular weight gelators have been an intense subject of study over the past decade. The self-assembling systems built from natural products have high significance as biocompatible materials and renewable resources. The versatile structures available from naturally existing monosaccharides have enriched the molecular libraries that can be used for the construction of gelators. The bottom-up strategy in designing low molecular weight gelators (LMWGs) for a variety of applications has been adopted by many researchers. Rational design, along with some serendipitous discoveries, has resulted in multiple classes of molecular gelators. This review covers the literature from 2017–2020 on monosaccharide based gelators, including common hexoses, pentoses, along with some disaccharides and their derivatives. The structure-based design and structure to gelation property relationships are reviewed first, followed by stimuli-responsive gelators. The last section focuses on the applications of the sugar based gelators, including their utilization in environmental remediation, ion sensing, catalysis, drug delivery and 3D-printing. We will also review the available LMWGs and their structure correlations to the desired properties for different applications. This review aims at elucidating the design principles and structural features that are pertinent to various applications and hope to provide certain guidelines for researchers that are working at the interface of chemistry, biochemistry, and materials science.

Amino-functional polyethers: versatile, stimuli-responsive polymers

2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey
Keyword(s):  
Ring Opening ◽  
Review Article ◽  
Stimuli Responsive ◽  
New Class ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

A peek in the micro-sized world: a review of design principles, engineering tools, and applications of engineered microbial community

2020 ◽  
Vol 48 (2) ◽  
pp. 399-409
Author(s):  
Baizhen Gao ◽  
Rushant Sabnis ◽  
Tommaso Costantini ◽  
Robert Jinkerson ◽  
Qing Sun
Keyword(s):  
Microbial Community ◽  
Microbial Communities ◽  
Environmental Remediation ◽  
Real Life ◽  
Design Principles ◽  
Microbial Interactions ◽  
Potential Applications ◽  
New Gene ◽  
Global Biogeochemical Cycles ◽  
Synthetic Microbial Communities

Microbial communities drive diverse processes that impact nearly everything on this planet, from global biogeochemical cycles to human health. Harnessing the power of these microorganisms could provide solutions to many of the challenges that face society. However, naturally occurring microbial communities are not optimized for anthropogenic use. An emerging area of research is focusing on engineering synthetic microbial communities to carry out predefined functions. Microbial community engineers are applying design principles like top-down and bottom-up approaches to create synthetic microbial communities having a myriad of real-life applications in health care, disease prevention, and environmental remediation. Multiple genetic engineering tools and delivery approaches can be used to ‘knock-in' new gene functions into microbial communities. A systematic study of the microbial interactions, community assembling principles, and engineering tools are necessary for us to understand the microbial community and to better utilize them. Continued analysis and effort are required to further the current and potential applications of synthetic microbial communities.

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