scholarly journals Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery

2017 ◽  
Vol 57 (3) ◽  
pp. 140-149 ◽  
Author(s):  
Yue Hu ◽  
Jochen Gaedcke ◽  
Georg Emons ◽  
Tim Beissbarth ◽  
Marian Grade ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Cancer Susceptibility ◽  
Predictive Markers ◽  
Cancer Prognosis ◽  
Susceptibility Loci

scholarly journals Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery

2017 ◽  
Author(s):  
Yue Hu ◽  
Jochen Gaedcke ◽  
Georg Emons ◽  
Tim Beissbarth ◽  
Marian Grade ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Cancer Progression ◽  
Cancer Susceptibility ◽  
Disease Free Survival ◽  
Colorectal Cancer Risk ◽  
Cancer Prognosis ◽  
Disease Free

AbstractBackgroundColorectal cancer (CRC) is among the leading causes of cancer death. Rectal cancers account for one third of CRC cases. The role and significance of colorectal cancer risk loci in rectal cancer progression has not been investigated.MethodsWe generated and explored a dataset from 230 rectal cancer patients by gene expression microarray analysis of cancer samples and matched controls, and SNP arrays of germline DNA.Results8q24 (upstream of MYC) and 18q21 (in the intron of SMAD7), two of the loci most strongly linked with colorectal cancer risk, as well as 20q13 (in the intron of LAMA5), are tightly associated with the prognosis of rectal cancer patients. For SNPs on 18q21 (rs12953717 and rs4464148) and 20q13 (rs4925386), alleles that correlate with higher risk for the development of colorectal cancer are associated with shorter disease free survival. However, for rs6983267 on 8q24, the low risk allele is associated with a higher risk for recurrence and metastasis after surgery, and importantly, is strongly correlated with the resistance of colorectal cancer cell lines to chemoradiotherapy. We also found that although MYC expression is dramatically increased in cancer, patients with higher levels of MYC have a better prognosis. The expression of SMAD7 is weakly correlated with disease free time. Notably, the presence of the 8q24 and 18q21 SNP alleles is not correlated with a change of expression of MYC and SMAD7. rs4464148, and probably rs6983267 and rs4925386, are linked with overall survival time of patients.ConclusionsSNPs at three colorectal cancer risk loci detect subpopulations of rectal cancer patients with poor prognosis. rs6983267 probably affects prognosis through interfering with the resistance of cancer cells to chemoradiotherapy.

scholarly journals Association Between Colorectal Cancer Susceptibility Loci and Survival Time After Diagnosis With Colorectal Cancer

2012 ◽  
Vol 143 (1) ◽  
pp. 51-54.e4 ◽  
Author(s):  
Amanda I. Phipps ◽  
Polly A. Newcomb ◽  
Xabier Garcia–Albeniz ◽  
Carolyn M. Hutter ◽  
Emily White ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Time ◽  
Cancer Susceptibility ◽  
Susceptibility Loci

Colorectal cancer susceptibility loci and influence on survival

2018 ◽  
Vol 57 (12) ◽  
pp. 630-637 ◽  
Author(s):  
Nan Song ◽  
Kyeezu Kim ◽  
Aesun Shin ◽  
Ji Won Park ◽  
Hee Jin Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Loci

scholarly journals Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Nan Song ◽  
Jeeyoo Lee ◽  
Sooyoung Cho ◽  
Jeongseon Kim ◽  
Jae Hwan Oh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Protective Factors ◽  
Risk Allele ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Regular Exercise ◽  
Susceptibility Loci ◽  
Gene Environment ◽  
Regular Aspirin

Abstract Background Genome-wide association studies (GWAS) have identified more than 40 colorectal cancer susceptibility loci, but only a small fraction of heritability was explained. To account for missing heritability, we investigated gene-environment interactions (G × Es) between GWAS-identified single-nucleotide polymorphisms (SNPs) and established risk or protective factors for colorectal cancer using both case-only and case-control study designs. Methods Data on 703 colorectal cancer cases and 1406 healthy controls from the National Cancer Center in Korea were used. We tested interactions between 31 GWAS-identified SNPs and 13 established risk or protective factors for colorectal cancer (family history, body mass index, history of colorectal polyps, inflammatory bowel disease, and diabetes mellitus, alcohol drinking, smoking, regular exercise, regular aspirin use, postmenopausal hormone replace therapy, red meat and processed meat intake, and dairy consumption). Logistic regression models were used to assess G × Es for colorectal cancer risk. Results The SNP rs4444235 at 14q22.2 interacted with regular exercise in colorectal cancer (pcase-only = 2.4 × 10− 3, pcase-control = 1.5 × 10− 3). The risk allele (C) of rs4444235 increased the risk of colorectal cancer in regularly exercising individuals (OR = 1.47, 95% CI = 1.02–2.10) but decreased the risk in non-exercising individuals (OR = 0.76, 95% CI = 0.62–0.94). Furthermore, the G × E between the SNP rs2423279 at 20p12.3 and regular aspirin use was statistically significant (pcase-only = 7.7 × 10− 3, pcase-control = 1.6 × 10− 3). The additive effect of the risk allele (T) of rs2423279 on colorectal cancer risk was increased among regular aspirin users (OR = 4.62, 95% CI = 1.97–10.80). Conclusion Our results suggest that SNP rs4444235 at 14q22.2 and SNP rs2423279 at 20p12.3 may interact with regular exercise and aspirin use in colorectal carcinogenesis.

scholarly journals Gene–Environment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci

2014 ◽  
Vol 23 (9) ◽  
pp. 1824-1833 ◽  
Author(s):  
Elizabeth D. Kantor ◽  
Carolyn M. Hutter ◽  
Jessica Minnier ◽  
Sonja I. Berndt ◽  
Hermann Brenner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Environment Interaction ◽  
Susceptibility Loci ◽  
Gene Environment Interaction ◽  
Gene Environment

scholarly journals Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type

2014 ◽  
Vol 180 (2) ◽  
pp. 223-232 ◽  
Author(s):  
A. N. Burnett-Hartman ◽  
P. A. Newcomb ◽  
C. M. Hutter ◽  
U. Peters ◽  
M. N. Passarelli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Colorectal Polyps ◽  
Susceptibility Loci ◽  
Polyp Type

scholarly journals Characterization of Gene–Environment Interactions for Colorectal Cancer Susceptibility Loci

2012 ◽  
Vol 72 (8) ◽  
pp. 2036-2044 ◽  
Author(s):  
Carolyn M. Hutter ◽  
Jenny Chang-Claude ◽  
Martha L. Slattery ◽  
Bethann M. Pflugeisen ◽  
Yi Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Loci ◽  
Gene Environment

scholarly journals BMP2 / BMP4 colorectal cancer susceptibility loci in northern and southern European populations

2012 ◽  
Vol 34 (2) ◽  
pp. 314-318 ◽  
Author(s):  
Ceres Fernandez-Rozadilla ◽  
Claire Palles ◽  
Luis Carvajal-Carmona ◽  
Paolo Peterlongo ◽  
Carmela Nici ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Loci ◽  
European Populations

scholarly journals Joint Effects of Colorectal Cancer Susceptibility Loci, Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92212 ◽  
Author(s):  
Linda T. Hiraki ◽  
Amit D. Joshi ◽  
Kimmie Ng ◽  
Charles S. Fuchs ◽  
Jing Ma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Susceptibility Loci ◽  
Joint Effects ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D
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