scholarly journals Protective effect of isoflavones and triterpenoid saponins from pueraria lobata on liver diseases: A review

2021 ◽  
Author(s):  
Heng He ◽  
Shuwei Peng ◽  
Xu Song ◽  
Renyong Jia ◽  
Yuanfeng Zou ◽  
...  
Keyword(s):  
Protective Effect ◽  
Liver Diseases ◽  
Pueraria Lobata ◽  
Triterpenoid Saponins

Inhibition of amyloid β aggregation and protective effect on SH-SY5Y cells by triterpenoid saponins from the cactus Polaskia chichipe

2017 ◽  
Vol 25 (13) ◽  
pp. 3377-3383 ◽  
Author(s):  
Koji Fujihara ◽  
Shin Koike ◽  
Yuki Ogasawara ◽  
Kunio Takahashi ◽  
Kiyotaka Koyama ◽  
...  
Keyword(s):  
Protective Effect ◽  
Amyloid Β ◽  
Triterpenoid Saponins

scholarly journals NOD1 Agonist Protects Against Lipopolysaccharide and D-Galactosamine-Induced Fatal Hepatitis Through the Upregulation of A20 Expression in Hepatocytes

2021 ◽  
Vol 12 ◽  
Author(s):  
Fang Jia ◽  
Fuxue Deng ◽  
Pan Xu ◽  
Shiying Li ◽  
Xuefu Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Liver Diseases ◽  
Tumor Necrosis ◽  
Hepatocyte Apoptosis ◽  
Potential Therapeutic Target ◽  
Apoptotic Protein ◽  
Tnf Α ◽  
Underlying Mechanisms ◽  
Necrosis Factor

Increasing evidence suggests that NODs are involved in liver diseases; however, the underlying mechanisms remain obscure. In the present study, we analyzed the effect of NOD1 agonist pretreatment on acute liver failure induced by lipopolysaccharide (LPS) in D-galactosamine (D-GalN)-sensitized mice. We found that pretreatment with the NOD1 agonist markedly reduced LPS/D-GalN-induced mortality, elevation of serum ALT levels, and hepatocyte apoptosis. The protective effect of NOD1 agonist was independent of tumor necrosis factor (TNF)-α inhibition. NOD1 agonist pretreatment also attenuated TNF-α/D-GalN-induced apoptotic liver damage. The anti-apoptotic protein A20 expression was more pronounced in NOD1 agonist pretreated mice than in controls, and knockdown of A20 abrogated the protective effect of NOD1 agonist on LPS/D-GalN-induced liver injury and hepatocyte apoptosis. Further experiments showed that NOD1 agonist-induced A20 upregulation required the presence of kupffer cells and TNF-α. Taken together, our data strongly indicate that NOD1 is involved in the regulation of liver injury and could be a potential therapeutic target for liver diseases.

Oleanane triterpenoid saponins from Millettia pulchra radix possessing protective effect on paraquat-induced neurotoxicity

2021 ◽  
Author(s):  
Thanh-Hoa Vo ◽  
Chia-Ching Liaw ◽  
Yu-Chi Lin ◽  
DucHanh Nguyen ◽  
Nai-Kuei Huang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Triterpenoid Saponins ◽  
Oleanane Triterpenoid

scholarly journals Cytoprotective Effect of Liposomal Puerarin on High Glucose-Induced Injury in Rat Mesangial Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1177
Author(s):  
Lassina Barro ◽  
Jui-Ting Hsiao ◽  
Chu-Yin Chen ◽  
Yu-Lung Chang ◽  
Ming-Fa Hsieh
Keyword(s):  
Protective Effect ◽  
Transforming Growth Factor Beta ◽  
High Glucose ◽  
High Performance ◽  
Transforming Growth Factor ◽  
Nuclear Translocation ◽  
Mesangial Cells ◽  
Diabetic Patients ◽  
Pueraria Lobata ◽  
Cytoprotective Effect

In diabetic patients, high glucose and high oxidative states activate gene expression of transforming growth factor beta (TGF-β) and further translocate Smad proteins into the nucleus of renal cells. This signal pathway is characterized as the onset of diabetic nephropathy. Puerarin is an active ingredient extracted from Pueraria lobata as an anti-hyperglycemic and anti-oxidative agent. However, the poor oral availability and aqueous solubility limit its pharmaceutical applications. The present paper reports the liposomal puerarin and its protective effect on high glucose-injured rat mesangial cells (RMCs). The purity of puerarin extracted from the root of plant Pueraria lobata was 83.4% as determined by the high-performance liquid chromatography (HPLC) method. The liposomal puerarin was fabricated by membrane hydration followed by ultrasound dispersion and membrane extrusion (pore size of 200 nm). The fabricated liposomes were examined for the loading efficiency and contents of puerarin, the particle characterizations, the radical scavenge and the protective effect in rat mesangial cells, respectively. When the liposomes were subjected to 20 times of membrane extrusion, the particle size of liposomal puerarin can be reduced to less than 200 nm. When liposomal puerarin in RMCs in high glucose concentration (33 mM) was administered, the over-expression of TGF-β and the nuclear translocation of Smad 2/3 proteins was both inhibited. Therefore, this study successfully prepared the liposomal puerarin and showed the cytoprotective effect in RMCs under high glucose condition.

scholarly journals Lactobacillus acidophilus LA14 Alleviates Liver Injury

mSystems ◽  
2021 ◽  
Author(s):  
Longxian Lv ◽  
Chunyan Yao ◽  
Ren Yan ◽  
Huiyong Jiang ◽  
Qiangqiang Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Lactobacillus Acidophilus ◽  
Liver Diseases ◽  
Content Type

The probiotic Lactobacillus acidophilus LA14 is widely used worldwide, but its effect on liver diseases has not been elucidated. We explored the protective effect of L. acidophilus LA14 on the liver using rats with d -galactosamine-induced liver injury.

785 OXIDATIVE DNA DAMAGE IN PATIENTS WITH CHRONIC HCV-RELATED LIVER DISEASES: PROTECTIVE EFFECT OF COFFEE CONSUMPTION

2011 ◽  
Vol 54 ◽  
pp. S315-S316
Author(s):  
R. Cardin ◽  
M. Piciocchi ◽  
D. Martines ◽  
L. Scribano ◽  
A. Floreani ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protective Effect ◽  
Liver Diseases ◽  
Oxidative Dna Damage ◽  
Coffee Consumption ◽  
Chronic Hcv

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Protective effect of chitooligosaccharides on hydrogen peroxide-induced PC-12 cells death by inhibition of oxidative damage

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Xueling Dai ◽  
Ping Chang ◽  
Ke Xu ◽  
Changjun Lin ◽  
Hanchang Huang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc 12 Cells ◽  
Cells Death
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