Inhibition of alcohol dehydrogenase activity by acetylenic and allylic alcohols: Concordance with in vivo electrophile reactivity in fish

1991 ◽  
Vol 10 (9) ◽  
pp. 1155-1160 ◽  
Author(s):  
Steven P. Bradbury ◽  
Glenn M. Christensen
1979 ◽  
Vol 17 (5-6) ◽  
pp. 553-563 ◽  
Author(s):  
Ira Papel ◽  
Melford Henderson ◽  
Jeanine Van Herrewege ◽  
Jean David ◽  
William Sofer

Tsitologiya ◽  
2018 ◽  
Vol 60 (6) ◽  
pp. 469-475
Author(s):  
O. D. Nimaeva ◽  
◽  
E. V. Pradedova ◽  
A. B. Karpova ◽  
R. K. Salyaev ◽  
...  

1972 ◽  
Vol 42 (6) ◽  
pp. 781-784 ◽  
Author(s):  
Maureen O'keane ◽  
M. R. Moore ◽  
A. Goldberg

1. Because it has been shown that a majority of alcoholics are subclinically scorbutic, the metabolism of ethanol was studied in subclinically-scorbutic guinea-pigs. 2. Hepatic alcohol dehydrogenase activity was raised maximally by ethanol within 2 days. 3. In twenty-three subclinically-scorbutic guinea-pigs fed ethanol for 2 weeks, the alcohol dehydrogenase activity (±SD) was 11·5 ± 1·2 units/g of liver protein compared with 8·6 ± 0·6 units/g of liver protein in twenty-three healthy animals fed ethanol. 4. The NAD+/NADH ratio in subclinically-scorbutic guinea-pigs and healthy guinea-pigs fed ethanol, shows that there is more NAD+ available for oxidation of alcohol in subclinically-scorbutic guinea-pigs. These results may explain the increased tolerance of alcoholics to alcohol.


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