Use of respiratory-cardiovascular responses of rainbow trout (Oncorhynchus mykiss) in identifying acute toxicity syndromes in fish: Part 4. Central nervous system seizure agents

1991 ◽  
Vol 10 (1) ◽  
pp. 115-131 ◽  
Author(s):  
Steven P. Bradbury ◽  
Richard W. Carlson ◽  
Gerald J. Niemi ◽  
Tala R. Henry
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rainbow Trout ◽  
Acute Toxicity ◽  
Oncorhynchus Mykiss ◽  
Cardiovascular Responses ◽  
Rainbow Trout Oncorhynchus Mykiss

Bioavailability and acute toxicity of copper to rainbow trout (Oncorhynchus mykiss) in the presence of organic acids simulating natural dissolved organic carbon

1999 ◽  
Vol 56 (8) ◽  
pp. 1471-1483 ◽  
Author(s):  
J CA Marr ◽  
J Lipton ◽  
D Cacela ◽  
J A Hansen ◽  
J S Meyer ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Organic Carbon ◽  
Acute Toxicity ◽  
Dissolved Organic Carbon ◽  
Oncorhynchus Mykiss ◽  
Failure Time ◽  
Life Stage ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Organic Complexes ◽  
Inorganic Species

Copper bioavailability and toxicity to early life stage rainbow trout (Oncorhynchus mykiss) were evaluated by laboratory toxicity testing performed using organic acid mixtures. Geochemical modeling was used to design exposure solutions that simulate dissolved organic carbon (DOC) of a natural aquatic system and to determine the fractions of total Cu present as inorganic species (e.g., Cu2+) and as individual Cu-organic complexes. Failure time modeling indicated that mortality was best predicted by a combination of total inorganic Cu and distinct Cu-organic complexes. The Cu-organic complexes that contributed to toxicity are characterized as low-affinity Cu-ligands, and our results support the hypothesis that Cu toxicity in nature is a function of the binding characteristics of individual ligands. Estimates of time-independent median lethal concentration thresholds determined at widely varying equivalent concentrations of DOC (0-16 mg/L) were constant (7.9-8.6 µg Cu/L) when modeled using the sum of inorganic Cu and Cu bound to the two low-affinity ligands as predictors of toxicity. Our results indicate that Cu bound to organic complexes may be available to fish and that acute toxicity of Cu is determined by the binding affinities of specific DOC components relative to Cu-binding affinity of fish gill.

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