Target site model: Application of the polyparameter target lipid model to predict aquatic organism acute toxicity for various modes of action

2018 ◽  
Vol 38 (1) ◽  
pp. 222-239 ◽  
Author(s):  
Kathleen S. Boone ◽  
Dominic M. Di Toro
Keyword(s):  
Acute Toxicity ◽  
Aquatic Organism ◽  
Target Site ◽  
Model Application ◽  
Site Model ◽  
Modes Of Action ◽  
Target Lipid Model

Acute toxicity of organic chemicals to Gammarus pulex correlates with sensitivity of Daphnia magna across most modes of action

2011 ◽  
Vol 103 (1-2) ◽  
pp. 38-45 ◽  
Author(s):  
Roman Ashauer ◽  
Anita Hintermeister ◽  
Eva Potthoff ◽  
Beate I. Escher
Keyword(s):  
Acute Toxicity ◽  
Daphnia Magna ◽  
Gammarus Pulex ◽  
Organic Chemicals ◽  
Modes Of Action

Discussion on Application of Biotic Ligand Model - The Tool to Predict Bioavailability of Metals

2015 ◽  
Vol 713-715 ◽  
pp. 2649-2652
Author(s):  
Guang Yang ◽  
Lin Zhu
Keyword(s):  
Acute Toxicity ◽  
Biological Effect ◽  
Theoretical Basis ◽  
Aquatic Organism ◽  
Biotic Ligand Model ◽  
Chemical Characteristics ◽  
Biotic Ligand ◽  
Future Direction ◽  
Realization Process ◽  
Ligand Model

Biotic ligand model (BLM) is a tool with the consideration of aquatic organism would have interaction with metals in different forms. Water chemical characteristics would also have some influence with bioavailability. In this study, BLM’s theoretical basis and realization process were discussed in detail, followed by the application status of the model. Finally, current challenges and future direction of BLM were pointed out. BLM assumes that the biological effect happens during the chemical equilibrium, which means that the model might only explain the acute toxicity results.

scholarly journals Prediction of acute toxicity in fish by using QSAR methods and chemical modes of action

2009 ◽  
Vol 25 (2) ◽  
pp. 195-203 ◽  
Author(s):  
Sylvain Lozano ◽  
Elodie Lescot ◽  
Marie-Pierre Halm ◽  
Alban Lepailleur ◽  
Ronan Bureau ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Modes Of Action

Acute Toxicity of Two Compounds with Different Modes of Action to the Zebrafish, Danio rerio

2002 ◽  
Vol 68 (2) ◽  
pp. 269-274
Author(s):  
E. W. M. Roex ◽  
M. C. T. van Langen ◽  
C. A. M. van Gestel
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Modes Of Action

Acute Toxicity of Two Compounds with Different Modes of Action to the Zebrafish,

2002 ◽  
Vol 68 (2) ◽  
pp. 0269-0274
Author(s):  
E. W. M. Roex ◽  
M. C. T. van Langen ◽  
C. A. M. van Gestel
Keyword(s):  
Acute Toxicity ◽  
Modes Of Action

Acute toxicity of 8 antidepressants: What are their modes of action?

Chemosphere ◽  
2014 ◽  
Vol 108 ◽  
pp. 314-319 ◽  
Author(s):  
Laetitia Minguez ◽  
Emilie Farcy ◽  
Céline Ballandonne ◽  
Alban Lepailleur ◽  
Antoine Serpentini ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Modes Of Action

scholarly journals Specificity of time- and dose-dependent morphological endpoints in the fish embryo acute toxicity (FET) test for substances with diverse modes of action: the search for a “fingerprint”

2021 ◽  
Author(s):  
Rebecca von Hellfeld ◽  
Pauline Pannetier ◽  
Thomas Braunbeck
Keyword(s):  
Acute Toxicity ◽  
Rapid Assessment ◽  
Toxicity Testing ◽  
Test Method ◽  
Test Protocol ◽  
Fish Embryo ◽  
Modes Of Action ◽  
Somite Formation ◽  
Hazard And Risk ◽  
Alternative Test

AbstractThe fish embryo acute toxicity (FET) test with the zebrafish (Danio rerio) embryo according to OECD TG 236 was originally developed as an alternative test method for acute fish toxicity testing according to, e.g., OECD TG 203. Given the versatility of the protocol, however, the FET test has found application beyond acute toxicity testing as a common tool in environmental hazard and risk assessment. Whereas the standard OECD guideline is restricted to four core endpoints (coagulation as well as lack of somite formation, heartbeat, and tail detachment) for simple, rapid assessment of acute toxicity, further endpoints can easily be integrated into the FET test protocol. This has led to the hypothesis that an extended FET test might allow for the identification of different classes of toxicants via a “fingerprint” of morphological observations. To test this hypothesis, the present study investigated a set of 18 compounds with highly diverse modes of action with respect to acute and sublethal endpoints. Especially at higher concentrations, most observations proved toxicant-unspecific. With decreasing concentrations, however, observations declined in number, but gained in specificity. Specific observations may at best be made at test concentrations ≤ EC10. The existence of a “fingerprint” based on morphological observations in the FET is, therefore, highly unlikely in the range of acute toxicity, but cannot be excluded for experiments at sublethal concentrations.

scholarly journals Assessing the anti-resistance potential of public health vaporizer formulations and insecticide mixtures with pyrethroids using transgenic Drosophila lines

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hang Ngoc Bao Luong ◽  
Arunas Damijonaitis ◽  
Ralf Nauen ◽  
John Vontas ◽  
Sebastian Horstmann
Keyword(s):  
Public Health ◽  
Insecticide Resistance ◽  
Vector Control ◽  
Pyrethroid Resistance ◽  
Indoor Residual Spraying ◽  
Target Site ◽  
Detoxification Enzymes ◽  
Modes Of Action ◽  
Commercial Mixture ◽  
Insecticide Mixtures

Abstract Background Insecticide resistance—and especially pyrethroid resistance—is a major challenge for vector control in public health. The use of insecticide mixtures utilizing alternative modes of action, as well as new formulations facilitating their uptake, is likely to break resistance and slow the development of resistance. Methods We used genetically defined highly resistant lines of Drosophila melanogaster with distinct target-site mutations and detoxification enzymes to test the efficacy and anti-resistance potential of novel mixture formulations (i.e. Fludora® Fusion consisting of deltamethrin and clothianidin), as well as emulsifiable concentrate transfluthrin, compared to alternative, currently used pyrethroid insecticide formulations for vector control. Results The commercial mixture Fludora® Fusion, consisting of both a pyrethroid (deltamethrin) and a neonicotinoid (clothianidin), performed better than either of the single active ingredients against resistant transgenic flies. Transfluthrin, a highly volatile active ingredient with a different molecular structure and primary exposure route (respiration), was also efficient and less affected by the combination of metabolic and target-site resistance. Both formulations substantially reduced insecticide resistance across different pyrethroid-resistant Drosophila transgenic strains. Conclusions The use of mixtures containing two unrelated modes of action as well as a formulation based on transfluthrin showed increased efficacy and resistance-breaking potential against genetically defined highly resistant Drosophila flies. The experimental model remains to be validated with mosquito populations in the field. The possible introduction of new transfluthrin-based products and mixtures for indoor residual spraying, in line with other combination and mixture vector control products recently evaluated for use in public health, will provide solutions for better insecticide resistance management. Graphical abstract

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