Three‐dimensional, porous, highly active α‐MnO 2 / prGO hybrid nanocomposites as cathode of non‐aqueous Li‐O 2 batteries

2021 ◽  
Author(s):  
Yueheng Fan ◽  
Aiming Wu ◽  
Xiaohui Yan ◽  
Shuiyun Shen ◽  
Zhang Junliang
Keyword(s):  
Three Dimensional ◽  
Hybrid Nanocomposites ◽  
Highly Active

scholarly journals Fe Containing Templates Derived Atomic Fe-N-C to Boost Fenton-Like Reaction and the Charge Migration Analysis on Highly Active Fe-N4 Sites

2021 ◽  
Author(s):  
Yuan Gao ◽  
Xiaoguang Duan ◽  
Bin Li ◽  
Qianqian Jia ◽  
Yang Li ◽  
...  
Keyword(s):  
Water Pollution ◽  
Vapor Deposition ◽  
Advanced Oxidation Processes ◽  
Three Dimensional ◽  
Chemical Vapor ◽  
Charge Migration ◽  
Carbon Nanosheets ◽  
Oxidation Processes ◽  
Highly Active ◽  
Migration Analysis

Persulfate-based advanced oxidation processes are promising technologies to solve water pollution. In this work, single iron atoms are anchored in three-dimensional N-doped carbon nanosheets by a chemical vapor deposition (CVD)...

scholarly journals WS(1−x)Sex Nanoparticles Decorated Three-Dimensional Graphene on Nickel Foam: A Robust and Highly Efficient Electrocatalyst for the Hydrogen Evolution Reaction

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 929 ◽  
Author(s):  
Sajjad Hussain ◽  
Kamran Akbar ◽  
Dhanasekaran Vikraman ◽  
Rana Afzal ◽  
Wooseok Song ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Hydrogen Evolution Reaction ◽  
Large Scale ◽  
Nickel Foam ◽  
Transition Metal Dichalcogenides ◽  
Three Dimensional ◽  
Cost Effective ◽  
Highly Efficient ◽  
Highly Active ◽  
Earth Abundant

To find an effective alternative to scarce, high-cost noble platinum (Pt) electrocatalyst for hydrogen evolution reaction (HER), researchers are pursuing inexpensive and highly efficient materials as an electrocatalyst for large scale practical application. Layered transition metal dichalcogenides (TMDCs) are promising candidates for durable HER catalysts due to their cost-effective, highly active edges and Earth-abundant elements to replace Pt electrocatalysts. Herein, we design an active, stable earth-abundant TMDCs based catalyst, WS(1−x)Sex nanoparticles-decorated onto a 3D porous graphene/Ni foam. The WS(1−x)Sex/graphene/NF catalyst exhibits fast hydrogen evolution kinetics with a moderate overpotential of ~−93 mV to drive a current density of 10 mA cm−2, a small Tafel slope of ~51 mV dec−1, and a long cycling lifespan more than 20 h in 0.5 M sulfuric acid, which is much better than WS2/NF and WS2/graphene/NF catalysts. Our outcomes enabled a way to utilize the TMDCs decorated graphene and precious-metal-free electrocatalyst as mechanically robust and electrically conductive catalyst materials.

scholarly journals Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer

2021 ◽  
Vol 13 ◽  
pp. 175883592110598
Author(s):  
Inken Flörkemeier ◽  
Tamara N. Steinhauer ◽  
Nina Hedemann ◽  
Magnus Ölander ◽  
Per Artursson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Topoisomerase I ◽  
Ex Vivo ◽  
Chemotherapy Resistance ◽  
Membrane Integrity ◽  
Three Dimensional ◽  
New Drugs ◽  
Highly Active ◽  
Gynaecologic Neoplasms

Background: Ovarian cancer (OvCa) constitutes a rare and highly aggressive malignancy and is one of the most lethal of all gynaecologic neoplasms. Due to chemotherapy resistance and treatment limitations because of side effects, OvCa is still not sufficiently treatable. Hence, new drugs for OvCa therapy such as P8-D6 with promising antitumour properties have a high clinical need. The benzo[ c]phenanthridine P8-D6 is an effective inductor of apoptosis by acting as a dual topoisomerase I/II inhibitor. Methods: In the present study, the effectiveness of P8-D6 on OvCa was investigated in vitro. In various OvCa cell lines and ex vivo primary cells, the apoptosis induction compared with standard therapeutic agents was determined in two-dimensional monolayers. Expanded by three-dimensional and co-culture, the P8-D6 treated cells were examined for changes in cytotoxicity, apoptosis rate and membrane integrity via scanning electron microscopy (SEM). Likewise, the effects of P8-D6 on non-cancer human ovarian surface epithelial cells and primary human hepatocytes were determined. Results: This study shows a significant P8-D6-induced increase in apoptosis and cytotoxicity in OvCa cells which surpasses the efficacy of well-established drugs like cisplatin or the topoisomerase inhibitors etoposide and topotecan. Non-cancer cells were affected only slightly by P8-D6. Moreover, no hepatotoxic effect in in vitro studies was detected. Conclusion: P8-D6 is a strong and rapid inductor of apoptosis and might be a novel treatment option for OvCa therapy.

High Thermal Conductive Inter Chip Fill for 3D-IC through Pre-applied Joining Process

2013 ◽  
Vol 2013 (1) ◽  
pp. 000408-000413
Author(s):  
Y. Kawase ◽  
M. Ikemoto ◽  
M. Yamazaki ◽  
M. Sugiyama ◽  
H. Kiritani ◽  
...  
Keyword(s):  
High Performance ◽  
Three Dimensional ◽  
Narrow Gap ◽  
Flux Agent ◽  
3D Ic ◽  
Conductive Materials ◽  
Highly Active ◽  
Fine Pitch ◽  
Joining Process ◽  
Active Flux

Three dimensional (3D) IC has been proposed for high performance and low power in recent years. Due to the narrow gap between stacked chips and fine pitch of bumps, new inter chip fill (ICF) which can be used for pre-applied ICF process is required. The heat generation of 3D-IC is higher than 2D, so that a high thermal conductive inter chip fill (HT-ICF) is simultaneously required to dissipate the heat from 3D-IC and for the purpose of pre-applied ICF and HT-ICF, highly active flux agent and thermal conductive materials such as filler and matrix have been called for at the same time. In this study, some kind of materials were prepared, synthesized and optimized for the HT-ICF, and we evaluated its characteristic and confirmed applicability to pre-applied joining for 3D-IC.

scholarly journals Facile Synthesis of Three-Dimensional Pt-TiO2 Nano-networks: A Highly Active Catalyst for the Hydrolytic Dehydrogenation of Ammonia-Borane

2016 ◽  
Vol 128 (40) ◽  
pp. 12445-12449 ◽  
Author(s):  
Mohammad Aref Khalily ◽  
Hamit Eren ◽  
Serdar Akbayrak ◽  
Hepi Hari Susapto ◽  
Necmi Biyikli ◽  
...  
Keyword(s):  
Active Catalyst ◽  
Three Dimensional ◽  
Ammonia Borane ◽  
Facile Synthesis ◽  
Highly Active

Computational Studies of 3D-QSAR on a Highly Active Series of Naturally Occurring Nonnucleoside Inhibitors of HIV-1 RT (NNRTI)

2020 ◽  
pp. 2050036
Author(s):  
Waqar Hussain ◽  
Arshia Majeed ◽  
Ammara Akhtar ◽  
Nouman Rasool
Keyword(s):  
Three Dimensional ◽  
3D Qsar ◽  
Qsar Modeling ◽  
Qsar Analysis ◽  
Qsar Studies ◽  
Highly Active ◽  
Naturally Occurring ◽  
Zinc Database ◽  
Immunodeficiency Syndrome ◽  
Hiv 1

HIV is one of the deadliest viruses in the history of mankind, it is the root cause of Acquired Immunodeficiency Syndrome (AIDS) around the world. Despite the fact that the antiviral therapy used against HIV-1 infection is effective, there is also rapidly growing cases of drug resistance in the infected patient along with different severe side effects. Therefore, it is of dire and immediate need to find novel inhibitors against HIV-1 Reverse Transcriptase (RT). In this study, the potential of naturally occurring compounds extracted from plants has been studied with the help of Three-Dimensional-Quantitative Structure–Activity Relationships (3D-QSAR) analysis. A total of 20 compounds, retrieved from a ZINC database, were analyzed with the help of 3D-QSAR to identify a potential inhibitor of HIV-1 RT. By evaluation of seven models generated with the help of MIF analysis and 3D-QSAR modeling, compound 3 (ZINC ID: ZINC20759448) was observed to outperform others by showing optimal results in QSAR studies. This compound has also been biologically validated by a recently reported previous study. Thus, this compound can be used as a potential drug against infection caused by HIV-1, specifically AIDS.

Facile Synthesis of Three-Dimensional PtPdNi Fused Nanoarchitecture as Highly Active and Durable Electrocatalyst for Methanol Oxidation

2017 ◽  
Vol 1 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Yanling Zhai ◽  
Zhijun Zhu ◽  
Xiaolin Lu ◽  
Zhiru Zhou ◽  
Jiahui Shao ◽  
...  
Keyword(s):  
Methanol Oxidation ◽  
Three Dimensional ◽  
Facile Synthesis ◽  
Highly Active

scholarly journals Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase

2005 ◽  
Vol 393 (2) ◽  
pp. 503-511 ◽  
Author(s):  
Sergey A. Shiryaev ◽  
Boris I. Ratnikov ◽  
Alexei V. Chekanov ◽  
Sergey Sikora ◽  
Dmitri V. Rozanov ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Protein A ◽  
Three Dimensional ◽  
Proteolytic Processing ◽  
Three Dimensional Model ◽  
West Nile ◽  
Highly Active ◽  
Polyprotein Precursor ◽  
Global Threat

Mosquito-borne WNV (West Nile virus) is an emerging global threat. The NS3 proteinase, which is essential for the proteolytic processing of the viral polyprotein precursor, is a promising drug target. We have isolated and biochemically characterized the recombinant, highly active NS3 proteinase. We have determined that the NS3 proteinase functions in a manner that is distantly similar to furin in cleaving the peptide and protein substrates. We determined that aprotinin and D-arginine-based 9–12-mer peptides are potent inhibitors of WNV NS3 with Ki values of 26 nM and 1 nM respectively. Consistent with the essential role of NS3 activity in the life cycle of WNV and with the sensitivity of NS3 activity to the D-arginine-based peptides, we showed that nona-D-Arg-NH2 reduced WNV infection in primary neurons. We have also shown that myelin basic protein, a deficiency of which is linked to neurological abnormalities of the brain, is sensitive to NS3 proteolysis in vitro and therefore this protein represents a convenient test substrate for the studies of NS3. A three-dimensional model of WNV NS3 that we created may provide a structural guidance and a rationale for the subsequent design of fine-tuned inhibitors. Overall, our findings represent a foundation for in-depth mechanistic and structural studies as well as for the design of novel and efficient inhibitors of WNV NS3.

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