Mutational specificity of animal cell DNA polymerases

1986 ◽  
Vol 8 (5) ◽  
pp. 769-789 ◽  
Author(s):  
John D. Roberts ◽  
Thomas A. Kunkel
Keyword(s):  
Animal Cell ◽  
Dna Polymerases ◽  
Mutational Specificity

Evidence from mutational specificity studies that yeast DNA polymerases δ and ϵ replicate different DNA strands at an intracellular replication fork 1 1Edited by A. R. Fersht

2000 ◽  
Vol 299 (2) ◽  
pp. 405-419 ◽  
Author(s):  
Ramachandran Karthikeyan ◽  
Edward J Vonarx ◽  
Andrew F.L Straffon ◽  
Michel Simon ◽  
Gérard Faye ◽  
...  
Keyword(s):  
Replication Fork ◽  
Dna Polymerases ◽  
Intracellular Replication ◽  
Mutational Specificity ◽  
Dna Strands

Animal cell DNA polymerases in DNA repair

1990 ◽  
Vol 236 (2-3) ◽  
pp. 289-300 ◽  
Author(s):  
Fred W. Perrino ◽  
Lawrence A. Loeb
Keyword(s):  
Dna Repair ◽  
Animal Cell ◽  
Dna Polymerases

Analysis of fidelity mechanisms with eukaryotic DNA replication and repair proteins

Genome ◽  
1989 ◽  
Vol 31 (1) ◽  
pp. 100-103 ◽  
Author(s):  
Thomas A. Kunkel ◽  
Katarzyna Bebenek ◽  
John D. Roberts ◽  
Mary P. Fitzgerald ◽  
David C. Thomas
Keyword(s):  
Dna Replication ◽  
Dna Synthesis ◽  
Animal Cell ◽  
Replication Complex ◽  
Error Frequency ◽  
Mutational Specificity ◽  
Sv40 Origin ◽  
Dna Replication And Repair ◽  
Eukaryotic Dna

We are investigating the mechanisms for producing or avoiding errors during DNA synthesis catalyzed by DNA replication and repair proteins purified from eukaryotic sources. Using assays that monitor the fidelity of a single round of DNA synthesis in vitro, we have defined the error frequency and mutational specificity of the four classes of animal cell DNA polymerases (α, β, δ, γ), and the fidelity of an SV40 origin-dependent DNA replication complex in extracts of HeLa cells.Key words: error frequency, repair proteins, polymerases, mutational specificity, fidelity mechanisms.

PrimPol (Primase/Polymerase), replicating enzyme – A mini review

2020 ◽  
Vol 2 (4) ◽  
pp. 89-92
Author(s):  
Muhammad Amir ◽  
Sabeera Afzal ◽  
Alia Ishaq
Keyword(s):  
Dna Replication ◽  
Dna Polymerase ◽  
Genetic Information ◽  
Nuclear Dna ◽  
De Novo ◽  
Dna Polymerases ◽  
Test Site ◽  
Mitochondrial Dna Replication ◽  
Dna Template ◽  
Preliminary Phase

Polymerases were revealed first in 1970s. Most important to the modest perception the enzyme responsible for nuclear DNA replication that was pol , for DNA repair pol and for mitochondrial DNA replication pol  DNA construction and renovation done by DNA polymerases, so directing both the constancy and discrepancy of genetic information. Replication of genome initiate with DNA template-dependent fusion of small primers of RNA. This preliminary phase in replication of DNA demarcated as de novo primer synthesis which is catalyzed by specified polymerases known as primases. Sixteen diverse DNA-synthesizing enzymes about human perspective are devoted to replication, reparation, mutilation lenience, and inconsistency of nuclear DNA. But in dissimilarity, merely one DNA polymerase has been called in mitochondria. It has been suggest that PrimPol is extremely acting the roles by re-priming DNA replication in mitochondria to permit an effective and appropriate way replication to be accomplished. Investigations from a numeral of test site have significantly amplified our appreciative of the role, recruitment and regulation of the enzyme during DNA replication. Though, we are simply just start to increase in value the versatile roles that play PrimPol in eukaryote.

Animal Cell Diagram

2018 ◽  
Author(s):  
Daniel Nelson
Keyword(s):  
Animal Cell
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