Detection of TEM-induced reciprocal translocations in F1 sons of CD-1 male mice: Comparison of sequential fertility evaluation and cytogenetic analysis

1988 ◽  
Vol 11 (2) ◽  
pp. 215-223 ◽  
Author(s):  
S. M. Morris ◽  
R. L. Kodell ◽  
O. E. Domon ◽  
J. B. Bishop
Keyword(s):  
Cytogenetic Analysis ◽  
Male Mice ◽  
Reciprocal Translocations

The effect of female strain on identification of male mice carrying reciprocal translocations

1984 ◽  
Vol 6 (6) ◽  
pp. 771-779 ◽  
Author(s):  
C. W. Sheu ◽  
J. N. Wang ◽  
F. M. Moreland
Keyword(s):  
Male Mice ◽  
Reciprocal Translocations ◽  
Female Strain

scholarly journals FEATURES OF THE KARYOTYPE OF NORTH CAUCASUS AYRSHIRE DAIRY CATTLE POPULATION: DEFECTS IN REPRODUCTIVE FUNCTIONS

2018 ◽  
Author(s):  
Vladimir TRUKHACHEV ◽  
Sergey OLEYNIK ◽  
Nikolay ZLYDNEV
Keyword(s):  
Dairy Cattle ◽  
Cytogenetic Analysis ◽  
Large Scale ◽  
Chromosomal Abnormalities ◽  
Genetic Load ◽  
Gene Mutations ◽  
North Caucasus ◽  
Reciprocal Translocations ◽  
Theoretical Assumptions ◽  
Ayrshire Breed

One of the ways of improving the genotypes of dairy cattle in Russia is to increase the proportion of the Ayrshire breed, which can be justly claimed to be one of the best dairy breeds in the world. However, due to the prevalence of large-scale breeding technologies, which involves the use of a limited contingent of dairy cattle bulls, including but not limited to the Ayrshire breed, the emergence of new-born calves with various anomalies, including chromosomal, which commonly have a hereditary basis attributable to gene mutations have been observed. Given that the bulk of these anomalies are acquired by recessive inheritance, they may not always manifest themselves in the phenotype and thus represent a hidden genetic load. In recent years, the significance of cytogenetic analysis and karyotyping is becoming increasingly important, not only when considering the theoretical assumptions, but also when solving applied problems aimed at preventing damage to agricultural production. This article presents the results of the cytogenetic analysis of Ayrshire cattle affected by reproductive problems. The following has been established: an absence of changes in the diploid set of the investigated dairy cattle (2n = 60); the presence of aberrant cells, whose frequency of occurrence amounted to 3.6% in the population of 440 head (number of aberrations per aberrant cell researched – 0.036 / 1.0); the absence of reciprocal translocations in the karyotype of the investigated population. It is suggested that the existing Ayrshire sires Hannulan Yaskiyri, Riihiviidan Urho Errant, O.R.Lihting and their descendants do not have a genetic load of chromosomal abnormalities.

scholarly journals Persistent in vivo cytogenetic effects of radioiodine therapy: a 21-year follow-up study using multicolor FISH

2017 ◽  
Vol 59 (1) ◽  
pp. 10-17 ◽  
Author(s):  
Gordon K Livingston ◽  
Maria Escalona ◽  
Alvis Foster ◽  
Adayabalam S Balajee
Keyword(s):  
Cytogenetic Analysis ◽  
Micronucleus Assay ◽  
Peripheral Blood Lymphocytes ◽  
Multicolor Fish ◽  
Reciprocal Translocations ◽  
Hematopoietic Stem ◽  
Follow Up Study ◽  
Cytogenetic Effects

Abstract Our previous studies demonstrated the cytogenetic effects in the peripheral blood lymphocytes of a 34-year-old male patient who received ablative radioactive 131iodine therapy (RIT) on two different occasions in 1992 and 1994. Assessment of RIT-induced chromosomal damage by the cytokinesis-blocked micronucleus assay (CBMN) showed the persistence of elevated micronucleus frequency in this patient for more than two decades since the first RIT. Subsequent cytogenetic analysis performed in 2012 revealed both stable and unstable aberrations, whose frequencies were higher than the baseline reported in the literature. Here, we report the findings of our recent cytogenetic analysis peformed in 2015 on this patient using the multicolor fluorescence in situ hybridization (mFISH) technique. Our results showed that both reciprocal and non-reciprocal translocations persisted at higher frequencies in the patient than those reported in 2012. Persistence of structural aberrations for more than two decades indicate that these aberrations might have originated from long-lived T-lymphocytes or hematopoietic stem cells. Our study suggests that the long-term persistence of chromosome translocations in circulating lymphocytes can be useful for monitoring the extent of RIT-induced chromosomal instability several years after exposure and for estimating the cumulative absorbed dose after multiple RITs for retrospective biodosimetry purposes. This is perhaps the first and longest follow-up study documenting the persistence of cytogenetic damage for 21 years after internal radiation exposure.

scholarly journals RECIPROCAL TRANSLOCATION t (6; 8) (q25-27; q23): CASE REPORT

2020 ◽  
Vol 55 (04) ◽  
pp. 67-68
Author(s):  
Aytakin Hasanova
Keyword(s):  
Reciprocal Translocation ◽  
Cytogenetic Analysis ◽  
Chromosomal Abnormalities ◽  
Normal Karyotype ◽  
Intrauterine Death ◽  
Reciprocal Translocations ◽  
Recurrent Miscarriages ◽  
Fetal Wastage ◽  
History Of ◽  
Recurrent Abortions

Reciprocal translocations are the most common structural chromosomal abnormalities in humans. In this study, the results of cytogenetic analysis performed on a couple with a reproductive history of three abortions and one intrauterine death referred to our laboratory are presented. Normal karyotype (46, XY) in male and reciprocal translocation 46XX t (6; 8) (q25-27; q23) in female were determined. In about 4% of couples with recurrent miscarriages, one of the parents is either a balanced reciprocal translocation or a robertsonian translocation carrier. Therefore, cytogenetic analysis should be recommended to couples with recurrent miscarriages. Keywords: Recurrent Abortions, Fetal Wastage, Reciprocal Translocation

Cytogenetic analysis of meiotic segregation in sperm from two males heterozygous for reciprocal translocations using PRINS and humster techniques

1997 ◽  
Vol 78 (3-4) ◽  
pp. 202-208 ◽  
Author(s):  
F. Pellestor ◽  
A. Girardet ◽  
L. Coignet ◽  
B. Andréo ◽  
G. Lefort ◽  
...  
Keyword(s):  
Cytogenetic Analysis ◽  
Meiotic Segregation ◽  
Reciprocal Translocations
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