scholarly journals FEATURES OF THE KARYOTYPE OF NORTH CAUCASUS AYRSHIRE DAIRY CATTLE POPULATION: DEFECTS IN REPRODUCTIVE FUNCTIONS

Author(s):  
Vladimir TRUKHACHEV ◽  
Sergey OLEYNIK ◽  
Nikolay ZLYDNEV

One of the ways of improving the genotypes of dairy cattle in Russia is to increase the proportion of the Ayrshire breed, which can be justly claimed to be one of the best dairy breeds in the world. However, due to the prevalence of large-scale breeding technologies, which involves the use of a limited contingent of dairy cattle bulls, including but not limited to the Ayrshire breed, the emergence of new-born calves with various anomalies, including chromosomal, which commonly have a hereditary basis attributable to gene mutations have been observed. Given that the bulk of these anomalies are acquired by recessive inheritance, they may not always manifest themselves in the phenotype and thus represent a hidden genetic load. In recent years, the significance of cytogenetic analysis and karyotyping is becoming increasingly important, not only when considering the theoretical assumptions, but also when solving applied problems aimed at preventing damage to agricultural production. This article presents the results of the cytogenetic analysis of Ayrshire cattle affected by reproductive problems. The following has been established: an absence of changes in the diploid set of the investigated dairy cattle (2n = 60); the presence of aberrant cells, whose frequency of occurrence amounted to 3.6% in the population of 440 head (number of aberrations per aberrant cell researched – 0.036 / 1.0); the absence of reciprocal translocations in the karyotype of the investigated population. It is suggested that the existing Ayrshire sires Hannulan Yaskiyri, Riihiviidan Urho Errant, O.R.Lihting and their descendants do not have a genetic load of chromosomal abnormalities.

2020 ◽  
Vol 55 (04) ◽  
pp. 67-68
Author(s):  
Aytakin Hasanova

Reciprocal translocations are the most common structural chromosomal abnormalities in humans. In this study, the results of cytogenetic analysis performed on a couple with a reproductive history of three abortions and one intrauterine death referred to our laboratory are presented. Normal karyotype (46, XY) in male and reciprocal translocation 46XX t (6; 8) (q25-27; q23) in female were determined. In about 4% of couples with recurrent miscarriages, one of the parents is either a balanced reciprocal translocation or a robertsonian translocation carrier. Therefore, cytogenetic analysis should be recommended to couples with recurrent miscarriages. Keywords: Recurrent Abortions, Fetal Wastage, Reciprocal Translocation


2011 ◽  
Vol 15 (7-8) ◽  
pp. 475-482 ◽  
Author(s):  
Afig Berdeli ◽  
Sevgi Mir ◽  
Sinem Nalbantoglu ◽  
Necil Kutukculer ◽  
Betül Sozeri ◽  
...  

2021 ◽  
Vol 18 (3) ◽  
pp. 410-420
Author(s):  
Vladimir N. KAVKAZKY ◽  
◽  
Yana V. MEL’NIK ◽  
Alexey P. LEIKIN ◽  
Andrey V. BENIN ◽  
...  

Objective: Chirkeyskaya HPP is by far the most powerful hydroelectric power plant in the North Caucasus with the highest arched dam in Russia and the second highest dam in the country after the Sayano-Shushenskaya HPP. This explains why it is called the pearl of the Caucasus. Methods: For the operation and maintenance of this unique structure, a large-scale complex of underground structures for various purposes was built, the technical condition of which must be constantly monitored. To carry out work on the survey of underground structures, the management of the design and survey institute of JSC “Lengidroproekt” decided to attract specialists from the Department of Tunnels and Subways and the Test Center “Strength” of Emperor Alexander I Petersburg State Transport University. The work was successfully carried out at the end of 2015. Results: The safety of underground structures was objectively assessed. Recommendations for the repair and further comprehensive reconstruction of the Chirkeyskaya HPP have been developed. Practical importance: Carry out work on the survey of underground structures of Chirkeyskaya HPP is allowes elaborate of complex measures on safety from Chirkeyskaya HPP.


2018 ◽  
Vol 18 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Alessandra Bernadete Trovó de Marqui

Abstract Objectives: to describe the prevalence and types of chromosomal abnormalities in couples with recurrent miscarriage and products of conception. Methods: electronic searches were performed in the PubMed/Medline database and in the Portal Regional da Biblioteca Virtual em Saúde/BVS (Regional Website of the Virtual Library in Health/BVS) using the descriptors “chromosomal abnormalities and abortions and prevalence”. After applying the inclusion and exclusion criterias, 17 studies were selected. Results: 11 studies were conducted in couples with recurrent miscarriage and six in products of conception. The main results of the couples with recurrent miscarriage were: the frequency of chromosomal abnormalities which varied from 1.23% to 12% and there was a predominance alteration of the chromosomal structures (reciprocal translocations, followed by Robertsonian). In products of conception, the results observed were: the frequency of chromosomal abnormality was above 50% in approximately 70% of the studies; there was a predominance alteration of the numerical chromosomal (trisomy - chromosomes 16, 18, 21 and 22, followed by polyploidy and monosomy X). Conclusions: in summary, cytogenetic alterations represent an importante cause of pregnancy loss and its detection can help couples with genetic counseling. Therefore, the value of knowledge on the prevalence of cytogenetic abnormalities in miscarriage samples is unquestionable, once it is permitted a proper genetic counseling for the couple.


2020 ◽  
Vol 12 (3) ◽  
pp. 349-356
Author(s):  
Vyacheslav BABURIN ◽  
◽  
Svetlana BADINA ◽  

The article proposes a methodological approach to potential damage from natural hazards forecasting in case of large-scale investment projects realization in ski tourism planning, as well as to assessing changes in the vulnerability of the territory in which these projects will be implemented. The method was verified on the data of the “Northern Caucasus Resorts” tourist cluster. The study purpose is the creation and verification of a methodology for socio-economic damage predicting in limit values and vulnerability changing in the regions of the “North Caucasus Resorts” tourist cluster objects localization for the long term. Research methods – statistical (a structural approach based on the identification of common structural patterns of several sets). The lack of statistical information on significant parameters for forecasting determine necessitates of using the various logically non-contradictory revaluations based on the identified structural similarities for the calculation of their values within the planning horizon. The study results and main conclusions – in case of the “North Caucasus Resorts” tourist cluster creation the number of people potentially located in avalanche and mudflow danger areas will significantly increase in all of its facilities localization municipalities, which indicate an increase in the individual risk of death level for this territory. The present population in the ski season in some of the most remote and underdeveloped areas can increase up to 30 times. The increment in the value of the fixed assets for the municipalities under consideration will be from two to 90 times, potential damages in limit values will reach tens of billions rubles.


2018 ◽  
Vol 51 ◽  
pp. 41-60 ◽  
Author(s):  
M. V. Gladiy ◽  
Yu. P. Polupan ◽  
I. V. Bazyshina ◽  
A. E. Pochukalyn ◽  
T. P. Koval ◽  
...  

Ukrainian population of red dairy cattle is genetically active, its gene pool is significantly improved in each of the next generations, mainly due to artificial selection. Currently breeding structure of Ukrainian Red Dairy breed has the prospect of future expansion due to creating Podolian zonal type. Features of its formation are to use as the original breed, which being improved, Red Polish cattle. This breed, as Red Steppe cattle, was listed as a breed to preserve the gene pool under pure breeding. However, gene pool preservation of these breeds is impossible through lack of sufficient number of purebred bulls or their semen at breeding enterprises in Ukraine. The aim of our research was to study genesis and development prospects of red dairy cattle in Ukraine. Materials and methods of research. The materials of the research were the data of identifying breed composition of cattle in Ukraine by January 1, 2015, State Breeding List for 2005, 2010 and 2015, the electronic information database of leading breeding farms for 2007 and 2011 and database of bulls admitted to using during 2005, 2010 and 2015 of Institute of Animal Breeding and Genetics named after M.V. Zubets of NAAS. Results. Currently the group of cows of red breeds is about 365 thousand head, including 97.9 thousand head concentrated in agricultural enterprises. The largest share of this group takes the Red Steppe cattle (84.5%), the smallest one –Ayrshire and Angler breeds (0.7-0.8%). In Ukraine, the total number of Ukrainian Red Dairy cattle is about 40 thousand head, including 21.4 thousand head of cattle concentrated in agricultural enterprises. The results of these annual reports have shown that the average milk yield of the group of cows of red breeds was 3328 kg of milk in 2001. Then milk yield increased with each subsequent studied period and reached the highest figure of 4681 kg in 2014. So, increasing milk yield of cows was by 1353 kg of milk or 29% during fourteen years (2001-2014). The number of breeding animals of Red Steppe, Red Polish, Ayrshire, and Ukrainian Red Dairy breeds significantly decreased in the controlled part of population during the past fourteen years. However, level of milk production and quality increased slightly, except for Red Polish breed. Thus, 4688 cows of Ukrainian Red Dairy breed had milk yield in 5981 kg and milk fat content in 3.88% according to the appraisal of 2014, whereas, in 2013, 4902 cows had milk yield in 5837 kg with milk fat content in 3.86%. Up to 90% of the realized genetic progress in large-scale breeding is provided by using proven bulls, resulting most current need is to restore the national system of selection and testing of sires. The results show that during the past ten years, the number of proven bulls, admitted to using within the red breeds decreased almost seven times with a simultaneous increase 2.2 times in breeding value. Among 410 proven bulls, admitted to using in 2005 (bulls which being tested by progeny), unreasonably disproportionate share was for Holstein sires – 245 (59.8%), whereas, the share of bulls of the red breeds – 13.7%. In 2010, 123 bulls (65.4%) were of Holstein breed and only 9 ones (4.8%) – of Ukrainian Red Dairy among 188 bulls, admitted to using. In 2014, a similar situation was observed; there were 93 bulls, admitted to using, including 48 ones (51.6%) of Holstein and only 3 ones (3.2%) of Ukrainian Red Dairy breed. Given the current state of livestock breeding base on all the red breeds (Red Steppe, Ukrainian Red Dairy, Angler, Red Polish) we developed possible options of parameters of large-scale breeding. During the planning period the number of the controlled cows of the red breeds (mainly Ukrainian Red Dairy cattle) should be significantly increased. Calculations show that in the first stage of the program available number of cows in breeding farms, even if 30% of cows allocated to mating with laid-off bulls, is less than a third of the minimum at pressure of selection among laid-off bulls 1: 4 by productivity of 50 daughters. At the end of the program it is planned to increase the pressure of selection among laid-off bulls to 1:5 under increase of the controlled livestock number to 43700 cows (nearly 4.4 times against currently available one) Conclusion. Our results showed that, the number of breeding farms, in which were bred red cattle, significantly declined and the livestock number also decreased whereas milk production increased during 2001-2015. The high level of genetic potential of Ukrainian Red Dairy cows indicates the presence of highest-yielding cows with yield more than 10 000 kg of milk. At the same time, such animals at breeding farms for breeding Red Polish, Steppe, Ayrshire and Angler cattle weren’t found. During the past ten years, the number of proven bulls of red breeds, admitted to using, decreased almost seven times with a simultaneous increase of breeding value in 2.2 times. Predominance of Holstein bulls remains indisputable on reliability of assessment of breeding value. It causes the biggest request and the widest offer on the market of semen from bulls of the breed. The actual destruction of domestic system of sires breeding caused significantly lower rate of repeatability of breeding values in bulls of the red breeds. This is a concern and threatens possible loss or significant restriction of the gene pool of red breeds.


TECHNOLOGOS ◽  
2020 ◽  
pp. 47-57
Author(s):  
Neroslov Alexey

In 1943, at the height of the Great Patriotic War, the new revolutionary drilling technique with high efficiency was used in Krasnokamsk oilfield of Molotov (Perm) Oblast for the first time in the world – the cluster turbodrilling method. The development of oil industry in Prikamye in the 1940s was associated with certain complications. The main deposits of the Krasnokasmk oilfield discovered before the war turned out to be located due to a number of reasons within the area of industrial and residential construction of the city of Krasnokamsk and under the Kama river and the Paltinskoye swamp close to the city. Conventional drilling methods could not be used for their development. The way out was to use the method of directional drilling that was little known at that moment. The development of the innovative technology in Krasnokamsk oilfield in 1942 was largely due to the involvement of the specialists of the Experimental Turbodrilling Bureau evacuated from Baku. Directional drilling which involved the deviation of the bottom hole (the ultimate lowest point of the well) from the wellhead (the initial uppermost location) by several hundred metres opened up broad opportunities for developing hard-to-recover oil deposits while significantly accelerating and ensuring cost savings of the drilling process. The directional drilling served as the basis for the development in Prikamye of an advanced technology of cluster drilling when several directional wells with different azimuths were drilled from a small well pad. In 1943–1944, cluster drilling was tested and successfully used in Krasnokamsk oilfield. The cluster drilling comprised an entire range of innovative solutions including the movement of assembled drilling rigs without dismantling power equipment. Also, it resulted in the reduction of total labour costs, scope of construction and assembly works, costs of building oilfield roads, power lines and pipelines, and transportation costs. People’s Commissariat of Oil Industry of the USSR initiated a large-scale rollout of the advanced method of cluster drilling in the largest oil-producing regions of the Soviet Union – Azerbaijan and the North Caucasus, and the area of the “second Baku” – Bashkiria, Tatary, and Kuybyshev oblast. The transition to the advanced and cost-saving technology of cluster drilling laid the foundation for the technical and economic revolution of the world drilling practices.


Author(s):  
Gunnar Völkel ◽  
Simon Laban ◽  
Axel Fürstberger ◽  
Silke D Kühlwein ◽  
Nensi Ikonomi ◽  
...  

Abstract Motivation Cancer is a complex and heterogeneous disease involving multiple somatic mutations that accumulate during its progression. In the past years, the wide availability of genomic data from patients’ samples opened new perspectives in the analysis of gene mutations and alterations. Hence, visualizing and further identifying genes mutated in massive sets of patients are nowadays a critical task that sheds light on more personalized intervention approaches. Results Here, we extensively review existing tools for visualization and analysis of alteration data. We compare different approaches to study mutual exclusivity and sample coverage in large-scale omics data. We complement our review with the standalone software AVAtar (‘analysis and visualization of alteration data’) that integrates diverse aspects known from different tools into a comprehensive platform. AVAtar supplements customizable alteration plots by a multi-objective evolutionary algorithm for subset identification and provides an innovative and user-friendly interface for the evaluation of concurrent solutions. A use case from personalized medicine demonstrates its unique features showing an application on vaccination target selection. Availability AVAtar is available at: https://github.com/sysbio-bioinf/avatar Contact [email protected], phone: +49 (0) 731 500 24 500, fax: +49 (0) 731 500 24 502


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