scholarly journals A comparison of classical and 21st century genotoxicity tools: A proof of concept study of 18 chemicals comparing in vitro micronucleus, ToxTracker and genomics‐based methods ( TGx‐DDI , whole genome clustering and connectivity mapping)

2020 ◽  
Author(s):  
Ashley Allemang ◽  
K. Nadira De Abrew ◽  
Yuqing K. Shan ◽  
Jesse M. Krailler ◽  
Stefan Pfuhler
Keyword(s):  
21St Century ◽  
Whole Genome ◽  
Proof Of Concept ◽  
Concept Study ◽  
Connectivity Mapping

In vitro effects of mechanical stimulation and photobiomodulation on osteoblastic cell function: A proof of concept study

2017 ◽  
Vol 27 (1) ◽  
pp. 29-41 ◽  
Author(s):  
Rochaya Chintavalakorn ◽  
Anak Khantachawana ◽  
Kwanchanok Viravaidya-Pasuwat ◽  
Peerapong Santiwong ◽  
Rudee Surarit
Keyword(s):  
Mechanical Stimulation ◽  
Cell Function ◽  
Osteoblastic Cell ◽  
Proof Of Concept ◽  
Concept Study ◽  
In Vitro Effects

scholarly journals Microvalve bioprinting of MSC-Chondrocyte Co-Cultures

2021 ◽  
Author(s):  
Joseph Dudman ◽  
Ana Marina Ferreira ◽  
Piergiorgio Gentile ◽  
Xiao Wang ◽  
Kenneth Dalgarno
Keyword(s):  
High Throughput Screening ◽  
Cellular Therapy ◽  
Cell Types ◽  
Inhibitory Effect ◽  
Proof Of Concept ◽  
Concept Study ◽  
Indirect Immunofluorescence Staining ◽  
Chondrocyte Implantation ◽  
Tissue Models

Recent improvements within the fields of high-throughput screening and 3D tissue culture have provided the possibility of developing in vitro micro-tissue models that can be used to study diseases and screen potential new therapies. This paper reports a proof of concept study on the use of microvalve-based bioprinting to create laminar MSC-chondrocyte co-cultures as an in vitro model of autologous chondrocyte implantation (ACI), an established cellular therapy for osteoarthritis. Microvalve-based bioprinting uses microvalves to deposit cells suspended in a liquid in a consistent and repeatable manner. In this case MSCs and chondrocytes have been sequentially deposited into an insert based transwell system in order to create a laminar co-culture, with variations in the ratios of the cell types used to investigate the potential for MSCs to stimulate improved repair. Histological and indirect immunofluorescence staining revealed the formation of dense tissue structures within the chondrocyte and MSC-chondrocyte cell co-cultures, alongside the establishment of a proliferative region at the base of the tissue. No stimulatory or inhibitory effect in terms of ECM production was observed through the introduction of MSCs, although the potential for an immunomodulatory benefit remains. This proof-of-concept study therefore provides a novel method to enable the scalable production of therapeutically relevant micro-tissue models that can be used for in vitro research to optimise ACI procedures.

scholarly journals Raman spectroscopy for the preoperative diagnosis of thyroid cancer and its subtypes: An in vitro proof-of-concept study

Cytopathology ◽  
2018 ◽  
Vol 30 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Declan O'Dea ◽  
Massimo Bongiovanni ◽  
Gerasimos P. Sykiotis ◽  
Panos G. Ziros ◽  
Aidan D. Meade ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Thyroid Cancer ◽  
Preoperative Diagnosis ◽  
Proof Of Concept ◽  
Concept Study ◽  
Diagnosis Of Thyroid Cancer

scholarly journals Triggered radiosensitizer delivery using thermosensitive liposomes and hyperthermia improves efficacy of radiotherapy: An in vitro proof of concept study

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0204063 ◽  
Author(s):  
Helena C. Besse ◽  
Clemens Bos ◽  
Maurice M. J. M. Zandvliet ◽  
Kim van der Wurff-Jacobs ◽  
Chrit T. W. Moonen ◽  
...  
Keyword(s):  
Proof Of Concept ◽  
Concept Study ◽  
Thermosensitive Liposomes

scholarly journals THE EXPRESSION OF ALPHA-FETOPROTEIN IN BLASTOCOEL FLUID-CONDITIONED MEDIA IN VITRO: A PROOF OF CONCEPT STUDY

2021 ◽  
Vol 116 (3) ◽  
pp. e131
Author(s):  
Shahryar K. Kavoussi ◽  
Shu-Hung Chen ◽  
J. David Wininger ◽  
Arnav Lal ◽  
William E. Roudebush ◽  
...  
Keyword(s):  
Alpha Fetoprotein ◽  
Conditioned Media ◽  
Proof Of Concept ◽  
Concept Study
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