In vitro evaluation of the genotoxic and cytotoxic effects of artesunate, an antimalarial drug, in human lymphocytes

2011 ◽  
Vol 52 (7) ◽  
pp. 590-594 ◽  
Author(s):  
Tatiane C. Mota ◽  
Plínio C. S. Cardoso ◽  
Lorena M. Gomes ◽  
Priscilla C. M. Vieira ◽  
Regianne M. S. Corrêa ◽  
...  
Keyword(s):  
Antimalarial Drug ◽  
Human Lymphocytes ◽  
Cytotoxic Effects ◽  
In Vitro Evaluation

scholarly journals In vitro evaluation of genomic damage induced by glyphosate on human lymphocytes

2018 ◽  
Vol 25 (34) ◽  
pp. 34693-34700 ◽  
Author(s):  
Alfredo Santovito ◽  
Stefano Ruberto ◽  
Claudio Gendusa ◽  
Piero Cervella
Keyword(s):  
Human Lymphocytes ◽  
In Vitro Evaluation ◽  
Genomic Damage

scholarly journals In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates

2003 ◽  
Vol 36 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Carla M.S. Menezes ◽  
Karin Kirchgatter ◽  
Sílvia M. Di Santi ◽  
Carine Savalli ◽  
Fabíola G. Monteiro ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antipsychotic Drug ◽  
Antimalarial Drug ◽  
Drug Susceptibility ◽  
Multidrug Resistant ◽  
Antiplasmodial Activity ◽  
Experimental Conditions ◽  
In Vitro Evaluation ◽  
Cardiovascular Therapy

Verapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propranolol, were also evaluated. Concentrations similar to those for cardiovascular therapy were used in the in vitro microtechnique for antimalarial drug susceptibility. Intrinsic antiplasmodial activity was observed from the lowest concentrations without a significant modulating action. Other reported modulating agents, such as the antipsychotic drug trifluoperazine and the antidepressants desipramine and imipramine, demonstrated similar responses under the same experimental conditions. Results suggest a much higher susceptibility of Brazilian strains, as well as an indifferent behaviour in relation to modulating agents.

scholarly journals Cereus jamacaru D.C. Hydroalcoholic Extract Promotes Anti-Cytotoxic and Antitumor Activity

2018 ◽  
Vol 11 (4) ◽  
pp. 130 ◽  
Author(s):  
Jean Vencioneck Dutra ◽  
Jean Moisés Ferreira ◽  
Paula Costalonga Pereira ◽  
Judá Ben-Hur de Oliveira ◽  
Suiany Vitorino Gervásio ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Human Lymphocytes ◽  
Sarcoma 180 ◽  
Flavonoid Content ◽  
Cytotoxic Effects ◽  
Hydroalcoholic Extract ◽  
Anticancer Effects ◽  
Tumor Reduction

Cereus jamacaru D.C. (mandacaru) is a cactus used as food and in the traditional medicine. In the present study, hydroalcoholic extract of C. jamacaru was evaluated for its chemical composition, antioxidant activity, cytotoxic and anti-cytotoxic effects in human lymphocytes and sarcoma 180 cells in vitro by MTT assay and antitumoral, mutagenic and cytotoxic effects on mice sarcoma-induced in vivo. Phytochemical characterization showed positive reactions for coumarin, flavanol and tyramine and total flavonoid content of 0.51 µg/mL. C. jamacaru showed antioxidant activity following DPPH (EC50 = 427.74 µg/mL), ABTS (EC50 = 270.57 µg/mL) and Fe2+ chelating ions assays (EC50 = 41.18 µg/mL). C. jamacaru induced significant decrease of sarcoma 180 viability at 24 h and 48 h of treatment, did not induce cytotoxicity in human lymphocytes and inhibits the cytotoxicity of cisplatin in vitro. Following in vivo assays, C. jamacaru promoted tumor reduction (86.07% of tumor inhibition), without inducing mutagenic or cytotoxic damage on mice blood cells. We propose that phenolic and alkaloid compounds in the extract are related to antioxidant activity, increasing its ability in metal chelating activity and promoting anti-cytotoxic activity against cisplatin, as well as these compounds may act on the cell cycle of the tumor cells in vitro and in vivo, leading to anticancer effects and tumor reduction.

Radioprotective activity and cytogenetic effect of resveratrol in human lymphocytes: An in vitro evaluation

2013 ◽  
Vol 51 ◽  
pp. 391-395 ◽  
Author(s):  
Natividad Sebastià ◽  
Miguel Almonacid ◽  
Juan Ignacio Villaescusa ◽  
José Cervera ◽  
Esperanza Such ◽  
...  
Keyword(s):  
Human Lymphocytes ◽  
Radioprotective Activity ◽  
In Vitro Evaluation ◽  
Cytogenetic Effect

A comparative in vitro evaluation of cytotoxic effects of EDTA and maleic acid: Root canal irrigants

2009 ◽  
Vol 108 (4) ◽  
pp. 633-638 ◽  
Author(s):  
N. Vasudev Ballal ◽  
M. Kundabala ◽  
Seetharama Bhat ◽  
Nageshwar Rao ◽  
B.S. Satish Rao
Keyword(s):  
Maleic Acid ◽  
Root Canal ◽  
Cytotoxic Effects ◽  
In Vitro Evaluation ◽  
Root Canal Irrigants

scholarly journals In vivo and in vitro evaluation of the cytotoxic effects of Photosan-loaded hollow silica nanoparticles on liver cancer

2014 ◽  
Vol 9 (1) ◽  
pp. 319 ◽  
Author(s):  
Zhong-Tao Liu ◽  
Li Xiong ◽  
Zhi-Peng Liu ◽  
Xiong-Ying Miao ◽  
Liang-Wu Lin ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Silica Nanoparticles ◽  
Cytotoxic Effects ◽  
Hollow Silica ◽  
In Vitro Evaluation ◽  
Hollow Silica Nanoparticles

scholarly journals Genotoxic and cytotoxic effects of formic acid on human lymphocytes in vitro

2016 ◽  
Vol 73 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Pınar Aksu ◽  
Gökhan Nur ◽  
Süleyman Gülkan ◽  
Ayşe Erciyas ◽  
Zeynep Tayfa ◽  
...  
Keyword(s):  
Formic Acid ◽  
Human Lymphocytes ◽  
Cytotoxic Effects
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