Evaluation of sulfated maltodextrin as a novel anionic chiral selector for the enantioseparation of basic chiral drugs by capillary electrophoresis

2014 ◽  
Vol 36 (2) ◽  
pp. 305-311 ◽  
Author(s):  
Hadi Tabani ◽  
Mojtaba Mahyari ◽  
Ali Sahragard ◽  
Ali Reza Fakhari ◽  
Ahmad Shaabani
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Chiral Drugs

Enantioseparation using carboxymethyl-6-(4-methoxybenzylamino)-β-cyclodextrin as a chiral selector by capillary electrophoresis and molecular modeling study of the recognition mechanism

2020 ◽  
Vol 44 (3) ◽  
pp. 958-972 ◽  
Author(s):  
Yu Zhao ◽  
Jinlong Wang ◽  
Yanru Liu ◽  
Zhen Jiang ◽  
Yongbo Song ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Modeling ◽  
Chiral Selector ◽  
Chiral Drugs ◽  
Recognition Mechanism ◽  
Molecular Modeling Study ◽  
First Time ◽  
Modeling Study

In this study, carboxymethyl-6-(4-methoxybenzylamino)-β-cyclodextrin (CMCDPN) was synthesized for the first time and managed to be used as a chiral selector to enantioseparate 13 kinds of chiral drugs by capillary electrophoresis.

scholarly journals Enantioselective Study on the Biodegradation of Verapamil and Cytalopram by Chiral Capillary Electrophoresis

Separations ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 29
Author(s):  
Yolanda Martín-Biosca ◽  
Laura Escuder-Gilabert ◽  
Salvador Sagrado ◽  
María José Medina-Hernández
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Minimal Salt Medium ◽  
Salt Medium ◽  
Chiral Drugs ◽  
Batch Mode ◽  
Chiral Compounds ◽  
Complete Filling ◽  
Abiotic Degradation ◽  
Chiral Capillary Electrophoresis

Many of the currently available drugs are chiral compounds that are marketed as racemates or, to a lesser extent, in the form of one of the enantiomers since a pair of enantiomers may have different toxicological and ecotoxicological properties compared to each other. The evaluation of enantioselectivity in biodegradation processes is essential for environmental risk assessment. The objective of this research is to study the enantioselectivity in the biodegradation of two common chiral drugs, citalopram and verapamil, using highly sulphated-γ-cyclodextrin (HS-γ-CD) as chiral selector in Capillary Electrophoresis. Biodegradation experiments were performed in batch mode using a minimal salt medium inoculated with an activated sludge and supplemented with the corresponding enantiomeric mixture. The cultures were incubated at 20 °C for 28 days. Abiotic degradation of verapamil and citalopram enantiomers was also assessed. The concentration of the enantiomers of verapamil and citalopram were monitored using 0.7% and 0.1% m/v HS-γ-CD solutions as chiral selector, respectively. Separations were carried out using the complete filling technique. The results of biodegradability tests indicate that citalopram could be considered potentially persistent while verapamil is presumed to be a non-persistent compound. No evidence of enantioselectivity was observed in any of the biodegradation processes.

Determination of enantiomeric excess for 2,3-dihydroxy-3-phenylpropionate compounds by capillary electrophoresis using hydroxypropyl-β-cyclodextrin as chiral selector

Chirality ◽  
2007 ◽  
Vol 19 (5) ◽  
pp. 380-385 ◽  
Author(s):  
Yan Zhao ◽  
Xing-Bin Yang ◽  
Qiao-Feng Wang ◽  
Peng-Juan Nan ◽  
Ying Jin ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Enantiomeric Excess ◽  
Chiral Selector

Evaluation of the macrocyclic antibiotic vancomycin as a chiral selector for capillary electrophoresis

Chirality ◽  
1994 ◽  
Vol 6 (6) ◽  
pp. 496-509 ◽  
Author(s):  
Daniel W. Armstrong ◽  
Kimber L. Rundlett ◽  
Jing-Ran Chen
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Macrocyclic Antibiotic
Sign in / Sign up

Export Citation Format

Share Document