Surface modification for PDMS-based microfluidic devices

2011 ◽  
Vol 33 (1) ◽  
pp. 89-104 ◽  
Author(s):  
Jinwen Zhou ◽  
Dmitriy A. Khodakov ◽  
Amanda V. Ellis ◽  
Nicolas H. Voelcker
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices

Tailormade Microfluidic Devices Through Photochemical Surface Modification

2010 ◽  
Vol 211 (2) ◽  
pp. 195-203 ◽  
Author(s):  
J. D. Jeyaprakash S. Samuel ◽  
Thilo Brenner ◽  
Oswald Prucker ◽  
Markus Grumann ◽  
Jens Ducree ◽  
...  
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices

Surface modification of polymer-based microfluidic devices

2002 ◽  
Vol 470 (1) ◽  
pp. 87-99 ◽  
Author(s):  
Steven A Soper ◽  
Alyssa C Henry ◽  
Bikas Vaidya ◽  
Michelle Galloway ◽  
Musundi Wabuyele ◽  
...  
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices

Surface modification of polydimethylsiloxane microchannel using air plasma for DNA capillary migration in polydimethylsiloxane–glass microfluidic devices

2013 ◽  
Vol 8 (6) ◽  
pp. 305-307 ◽  
Author(s):  
Maryam Alsadat Rad ◽  
Kamarulazizi Ibrahim ◽  
Khairudin Mohamed ◽  
Nazalan Najimudin
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices ◽  
Air Plasma

Surface modification of PDMS microfluidic devices by controlled sulfuric acid treatment and the application in chip electrophoresis

2014 ◽  
Vol 36 (3) ◽  
pp. 449-456 ◽  
Author(s):  
Leonid Gitlin ◽  
Philipp Schulze ◽  
Stefan Ohla ◽  
Hans-Josef Bongard ◽  
Detlev Belder
Keyword(s):  
Surface Modification ◽  
Sulfuric Acid ◽  
Acid Treatment ◽  
Microfluidic Devices ◽  
Sulfuric Acid Treatment

Toward Fabric-Based Flexible Microfluidic Devices: Pointed Surface Modification for pH Sensitive Liquid Transport

2012 ◽  
Vol 4 (9) ◽  
pp. 4541-4548 ◽  
Author(s):  
Fehime Vatansever ◽  
Ruslan Burtovyy ◽  
Bogdan Zdyrko ◽  
Karthik Ramaratnam ◽  
Taras Andrukh ◽  
...  
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices ◽  
Ph Sensitive ◽  
Liquid Transport

Microfabrication (Hot-Embossing) of COC Microfluidic Devices: Effect of Norbornene Content on Replication Fidelity and Surface Modification by UV-Photografting

2013 ◽  
Vol 543 ◽  
pp. 51-54
Author(s):  
Rajeeb Kumar Jena ◽  
Chee Yoon Yue
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices ◽  
Processing Parameters ◽  
Hot Embossing ◽  
Contact Angle Measurement ◽  
Angle Measurement ◽  
Experimental Conditions ◽  
Water Contact ◽  
Replication Fidelity ◽  
Modified Surface

The fabrication of polymer based microfluidic devices using the hot embossing technique and their surface modification for easy fluid flow through the devices has been a growing field of research. During hot embossing, the replication fidelity on polymer substrate not only depends on the processing parameters such as temperature, pressure and time but also on their chemical structure which affects their thermo-dependent viscoelastic properties. For copolymers such as cyclic olefin copolymer (COC) which comprises ethylene and norbornene units, such properties depend on their relative ethylene and norbornene content. We report in this paper, a systematic study of replication fidelity and surface modification on COC polymer with varying norbornene content from 65 to 82 wt%. Replication fidelity which includes the surface morphology and cross-section profiles of the microchannel were characterized using SEM and Confocal microscope respectively. The modified surface was evaluated using Fourier transform infrared spectroscopy (FTIR spectroscopy) and water contact angle measurement. It was observed that in hot embossing, higher norbornene content contributed to good replication fidelity at identical experimental conditions. Furthermore, it was observed that with increase in norbornene content, the grafting efficiency decreases resulting in poor surface modification.

scholarly journals Surface modification of PDMS-based microfluidic devices with collagen using polydopamine as a spacer to enhance primary human bronchial epithelial cell adhesion

2020 ◽  
Author(s):  
Mohammadhossein Dabaghi ◽  
Shadi Shahriari ◽  
Neda Saraei ◽  
Kevin Da ◽  
Abiram Chandiramohan ◽  
...  
Keyword(s):  
Cell Culture ◽  
Surface Modification ◽  
Cell Adhesion ◽  
Microfluidic Devices ◽  
Extracellular Matrix Protein ◽  
Shear Stresses ◽  
Bronchial Epithelial ◽  
Ecm Proteins ◽  
Coating Methods ◽  
Organ On A Chip

AbstractPolydimethylsiloxane (PDMS) is a silicone-based synthetic material that is used in various biomedical applications due to its properties, including transparency, flexibility, permeability to gases, and ease of use. Though PDMS facilitates and realizes the fabrication of complicated geometries at the micro and nano scales, it does not optimally interact with cells for adherence and proliferation. Different strategies have been proposed to render PDMS to enhance cell attachment. The majority of these surface modification techniques have been offered for a static cell culture system. However, dynamic cell culture systems such as organ-on-a-chip devices are demanding platforms that recapitulate the complexity of a living tissue microenvironment. For organ-on-a-chip platforms, PDMS surfaces are usually coated by ECM proteins, which occur as a result of physical, weak bonding between PDMS and ECM proteins, and this binding can be degraded when it is exposed to shear stresses. This work reports static and dynamic coating methods to covalently bind collagen within a PDMS-based microfluidic device using polydopamine (PDA). These coating methods were evaluated using water contact angle measurement and atomic force microscopy (AFM) to find the optimum coating conditions. The biocompatibility of collagen-coated PDMS devices was assessed by culturing primary human bronchial epithelial cells (HBECs) in microfluidic devices. It was shown that both PDA coating methods could be used to bind collagen, thereby improving cell adhesion (around three times higher) without showing any discernible difference. These results suggested that such a surface modification can be used to coat an extracellular matrix protein onto PDMS-based microfluidic devices.

Geomaterial‐Functionalized Microfluidic Devices Using a Universal Surface Modification Approach

2019 ◽  
Vol 6 (23) ◽  
pp. 1900995 ◽  
Author(s):  
Yaqi Zhang ◽  
Gurkan Yesiloz ◽  
Hossein Jiryaei Sharahi ◽  
Hossein Khorshidian ◽  
Seonghwan Kim ◽  
...  
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices

Recent developments in PDMS surface modification for microfluidic devices

2010 ◽  
Vol 31 (1) ◽  
pp. 2-16 ◽  
Author(s):  
Jinwen Zhou ◽  
Amanda Vera Ellis ◽  
Nicolas Hans Voelcker
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices ◽  
Pdms Surface ◽  
Recent Developments

Development of a Plasma Process for Microfluidic Devices in the Prospect of Cell Attachment

2010 ◽  
Vol 89-91 ◽  
pp. 598-603
Author(s):  
Nathalie Vo Tan Tho ◽  
Hervé Willaime ◽  
Patrick Tabeling ◽  
Farzaneh Arefi-Khonsari ◽  
D. Mantovani ◽  
...  
Keyword(s):  
Surface Modification ◽  
Vapor Deposition ◽  
Low Temperatures ◽  
Cell Attachment ◽  
Chemical Vapor ◽  
Microfluidic Devices ◽  
Microfluidic System ◽  
Plasma Process ◽  
Dry Process ◽  
Inner Surface

Plasma processing has been developed to produce selective chemistry in the inner surface of a microfluidic system. This dry process is an alternative solution to the Chemical Vapor Deposition (CVD) process that allows us to work at low temperatures thus avoiding the degradation of the substrate by heat. The present study focused on the surface modification of PDMS in order to make them more hydrophilic and capable to exhibit a high percentage of COOH functions which will provide a good asset for future cell attachment.

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