A method for quantitative analysis of an anticancer drug in human plasma with CE-ESI-TOF-MS

2011 ◽  
Vol 32 (13) ◽  
pp. 1778-1785 ◽  
Author(s):  
Anisa Elhamili ◽  
Jonas Bergquist
Keyword(s):  
Quantitative Analysis ◽  
Human Plasma ◽  
Anticancer Drug ◽  
Tof Ms

Quantitative Analysis of Artemether and its Metabolite Dihydroartemisinin in Human Plasma by LC with Tandem Mass Spectrometry

2006 ◽  
Vol 64 (9-10) ◽  
pp. 523-530 ◽  
Author(s):  
Bin Shi ◽  
Yunqiu Yu ◽  
Zhongdong Li ◽  
Li Zhang ◽  
Yan Zhong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
Tandem Mass Spectrometry ◽  
Human Plasma ◽  
Tandem Mass

Quantitative Analysis of Genistein in Human Plasma by Online Concentration CE with UV Detection

2008 ◽  
Vol 68 (5-6) ◽  
pp. 431-435 ◽  
Author(s):  
Hai-Yan Feng ◽  
Shu-Rong Hou ◽  
Na Zheng ◽  
Xiang-Jun Li ◽  
Zhong-Bo Hu ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Human Plasma ◽  
Uv Detection

Method for the quantitative analysis of cilostazol and its metabolites in human plasma using LC/MS/MS

2001 ◽  
Vol 26 (4) ◽  
pp. 637-650 ◽  
Author(s):  
Steven L Bramer ◽  
Prasad N.V Tata ◽  
Shailesh S Vengurlekar ◽  
Jerry H Brisson
Keyword(s):  
Quantitative Analysis ◽  
Human Plasma

A Profoundly Touchy Approved Spectrofluorimetric Approach for Assurance of Ixabepilone as Anticancer Drug by Utilizing Its Quenching Impact on Acetoxymercuric Fluorescein Reagent

2021 ◽  
pp. 39-52
Author(s):  
Hesham Salem ◽  
Amany Abdelaziz ◽  
Aliaa Gamal ◽  
Ramy El Sabaa
Keyword(s):  
Human Plasma ◽  
Anticancer Drug ◽  
Fluorescence Intensity ◽  
Solution Concentration ◽  
Quenching Effect ◽  
Bulk Powder ◽  
Optimized Conditions ◽  
Temperature Time ◽  
Sulfur Containing ◽  
Satisfactory Recovery

A dependable, sensitive, basic and cheap spectrofluorimetric approach has been created for test of sulfur-containing drug; ixabepilone in bulk powder, vials and human plasma. The approach depends on the quenching effect of ixabepilone on the fluorescence intensity of acetoxymercuric fluorescene (AMF) reagent at λem of 530 nm and λex of 500 nm. Parameters which will control the reaction such as pH, AMF solution concentration, temperature, time and solvents were examined and optimized. According to the optimized conditions, the proposed approach was practiced over the concentration area of 20-100 ng mL-1 with adequate linearity (r = 0.9998). The developed approach was approved confirming to ICH rules in terms of accuracy, precision, linearity, LOD and LOQ. The proposed approach was practiced to analyze ixabepilone in Ixempra® vials with satisfactory recovery % of 99.89 and RSE% of 1.24. The results achieved were compared to those achieved by an already reported HPLC approach.

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