Impedimetric DNA Sensor Based on Poly(proflavine) for Determination of Anthracycline Drugs

2020 ◽  
Vol 32 (4) ◽  
pp. 827-834 ◽  
Author(s):  
Anna V. Porfireva ◽  
Anastasia I. Goida ◽  
Alexey M. Rogov ◽  
Gennady A. Evtugyn
Keyword(s):  
Dna Sensor

ELECTROCHEMICAL DNA SENSOR TECHNOLOGY FOR MONITORING OF DRUG–DNA INTERACTIONS

NANO ◽  
2008 ◽  
Vol 03 (04) ◽  
pp. 229-232 ◽  
Author(s):  
A. ERDEM ◽  
H. KARADENIZ ◽  
A. CALISKAN ◽  
A. VASEASHTA
Keyword(s):  
Drug Delivery ◽  
Small Molecules ◽  
Anticancer Drugs ◽  
Point Of Care ◽  
Sensor Technology ◽  
Electrochemical Biosensors ◽  
Dna Sensor ◽  
Dna Interactions ◽  
Electrochemical Dna Sensor

The objective of this investigation is to understand the nature and dynamics of binding small molecules to bio-macromolecules using electrochemical methods. The investigation pertaining to the design of site- and conformation-specific reagents provides a rationale for new studies of drug delivery design. Some anticancer drugs and DNA interactions have been undertaken by using a variety of techniques. Determination of interaction between DNA and DNA-targeted molecules would be valuable in the design of molecule-specific electrochemical biosensors for applications in diagnostics, development of drugs for chemotherapy, and as a biotechnological tool for DNA-based point-of-care diagnosis.

scholarly journals Development of Electrochemical DNA Sensor for The Determination of Anaplasma Phagocytophilum

2017 ◽  
Vol 38 (4) ◽  
pp. 748-758
Author(s):  
Adil ELİK ◽  
Gültekin GÖKÇE ◽  
Çağdaş CEYLAN
Keyword(s):  
Anaplasma Phagocytophilum ◽  
Dna Sensor ◽  
Electrochemical Dna Sensor

scholarly journals Determination of L-Argininamide Based on Water-Soluble Fluorescent Conjugated Polymer-Aptamer

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Hongliang Guan ◽  
Zhike He
Keyword(s):  
Conjugated Polymer ◽  
Specific Binding ◽  
Water Soluble ◽  
Dna Sensor ◽  
Label Free ◽  
Binding Reaction ◽  
Molecular Sensors ◽  
Free Dna ◽  
Highly Sensitive

Water-soluble fluorescent conjugated polymer is a promising material which could be used as an optical platform in highly sensitive molecular sensors. In this paper, a simple label-free DNA sensor, which consisted of a poly(3-alkoxy-4-methylthiophene) and an aptamer, was used to detect L-argininamide (L-Arm). Due to the specific binding reaction between L-Arm and its aptamer, the proposed method can easily determinate the L-Arm through the recovery of fluorescence without any modification. Other ions or similar molecules had little effect on the detection. Moreover, there was a linear relationship between fluorescence intensity and the concentration of L-Arm. The detection limit of L-Arm was as low as 4.7 nM.

A label-free ratiometric electrochemical DNA sensor for monitoring intracellular redox homeostasis

2017 ◽  
Vol 53 (46) ◽  
pp. 6215-6218 ◽  
Author(s):  
Xinping Liu ◽  
Zhengqing Yan ◽  
Yuhuan Sun ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Redox Homeostasis ◽  
Electrochemical Determination ◽  
Dna Sensor ◽  
Label Free ◽  
Electrochemical Dna Sensor ◽  
Intracellular Redox

A label-free ratiometric electrochemical determination of GSH by DNA metallization-mediated HCR amplification is reported.

scholarly journals Electrochemical DNA Sensor Based on Acridine Yellow Adsorbed on Glassy Carbon Electrode

Sensors ◽  
2021 ◽  
Vol 21 (22) ◽  
pp. 7763
Author(s):  
Tatjana Kulikova ◽  
Anna Porfireva ◽  
Alexey Rogov ◽  
Gennady Evtugyn
Keyword(s):  
Carbon Black ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Dna Sensor ◽  
Acridine Yellow ◽  
Highly Sensitive ◽  
Plasma Electrolytes ◽  
Sensitive Determination

Electrochemical DNA sensors offer unique opportunities for the sensitive detection of specific DNA interactions. In this work, a voltametric DNA sensor is proposed on the base of glassy carbon electrode modified with carbon black, adsorbed acridine yellow and DNA for highly sensitive determination of doxorubicin antitumor drug. The signal recorded by cyclic voltammetry was attributed to irreversible oxidation of the dye. Its value was altered by aggregation of the hydrophobic dye molecules on the carbon black particles. DNA molecules promote disaggregation of the dye and increased the signal. This effect was partially suppressed by doxorubicin compensate for the charge of DNA in the intercalation. Sensitivity of the signal toward DNA and doxorubicin was additionally increased by treatment of the layer with dimethylformamide. In optimal conditions, the linear range of doxorubicin concentrations determined was 0.1 pM–1.0 nM, and the detection limit was 0.07 pM. No influence of sulfonamide medicines and plasma electrolytes on the doxorubicin determination was shown. The DNA sensor was tested on two medications (doxorubicin-TEVA and doxorubicin-LANS) and showed recoveries of 102–105%. The DNA sensor developed can find applications in the determination of drug residues in blood and for the pharmacokinetics studies.

scholarly journals Development of Electrochemical DNA Sensor for The Determination of Anaplasma Phagocytophilum

2017 ◽  
Vol 38 (3) ◽  
pp. 525-534
Author(s):  
Adil ELİK ◽  
Gültekin GÖKÇE ◽  
Ebru BOSTANCI ◽  
Derya KIZILOLUK
Keyword(s):  
Anaplasma Phagocytophilum ◽  
Dna Sensor ◽  
Electrochemical Dna Sensor
Sign in / Sign up

Export Citation Format

Share Document