Point-of-Care Smartphone-based Electrochemical Biosensing

2018 ◽  
Vol 31 (1) ◽  
pp. 2-16 ◽  
Author(s):  
Alexander C. Sun ◽  
Drew A. Hall
Keyword(s):  
Point Of Care ◽  
Electrochemical Biosensing

scholarly journals Revisiting Electrochemical Biosensing in the 21st Century Society for Inflammatory Cytokines Involved in Autoimmune, Neurodegenerative, Cardiac, Viral and Cancer Diseases

Sensors ◽  
2020 ◽  
Vol 21 (1) ◽  
pp. 189
Author(s):  
Susana Campuzano ◽  
Paloma Yáñez-Sedeño ◽  
José Manuel Pingarrón
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Accurate Determination ◽  
Test Time ◽  
Electrochemical Biosensing ◽  
Recent Developments ◽  
Inflammatory Processes ◽  
Human Skills ◽  
Cancer Diseases

The multifaceted key roles of cytokines in immunity and inflammatory processes have led to a high clinical interest for the determination of these biomolecules to be used as a tool in the diagnosis, prognosis, monitoring and treatment of several diseases of great current relevance (autoimmune, neurodegenerative, cardiac, viral and cancer diseases, hypercholesterolemia and diabetes). Therefore, the rapid and accurate determination of cytokine biomarkers in body fluids, cells and tissues has attracted considerable attention. However, many currently available techniques used for this purpose, although sensitive and selective, require expensive equipment and advanced human skills and do not meet the demands of today’s clinic in terms of test time, simplicity and point-of-care applicability. In the course of ongoing pursuit of new analytical methodologies, electrochemical biosensing is steadily gaining ground as a strategy suitable to develop simple, low-cost methods, with the ability for multiplexed and multiomics determinations in a short time and requiring a small amount of sample. This review article puts forward electrochemical biosensing methods reported in the last five years for the determination of cytokines, summarizes recent developments and trends through a comprehensive discussion of selected strategies, and highlights the challenges to solve in this field. Considering the key role demonstrated in the last years by different materials (with nano or micrometric size and with or without magnetic properties), in the design of analytical performance-enhanced electrochemical biosensing strategies, special attention is paid to the methods exploiting these approaches.

scholarly journals Nanomaterials for molecular signal amplification in electrochemical nucleic acid biosensing: recent advances and future prospects for point-of-care diagnostics

2020 ◽  
Vol 5 (1) ◽  
pp. 49-66 ◽  
Author(s):  
Léonard Bezinge ◽  
Akkapol Suea-Ngam ◽  
Andrew J. deMello ◽  
Chih-Jen Shih
Keyword(s):  
Nucleic Acid ◽  
Molecular Diagnostics ◽  
Signal Amplification ◽  
Point Of Care ◽  
Future Prospects ◽  
Electrochemical Biosensing ◽  
Recent Advances ◽  
Point Of Care Diagnostics ◽  
Molecular Signal

This account reviews the major amplification strategies utilizing nanomaterials in electrochemical biosensing for robust and sensitive molecular diagnostics.

Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Fatemeh Haghayegh ◽  
Razieh Salahandish ◽  
Azam Zare ◽  
Mahmood khalghollah ◽  
Amir Sanati Nezhad
Keyword(s):  
Point Of Care ◽  
Electrochemical Biosensing ◽  
Self Powered ◽  
On Chip ◽  
Bioanalytical Assays ◽  
Scalable Production ◽  
True Point

The realization of true point-of-care (PoC) systems profoundly relies on integrating the bioanalytical assays into “on-chip” fluid handing platforms, with autonomous performance, reproducible functionality, and capacity in scalable production. Specifically...

Gold nanostructured laser-scribed graphene: A new electrochemical biosensing platform for potential point-of-care testing of disease biomarkers

2021 ◽  
Vol 180 ◽  
pp. 113116
Author(s):  
Sakandar Rauf ◽  
Abdellatif Ait Lahcen ◽  
Abdulrahman Aljedaibi ◽  
Tutku Beduk ◽  
José Ilton de Oliveira Filho ◽  
...  
Keyword(s):  
Point Of Care ◽  
Point Of Care Testing ◽  
Disease Biomarkers ◽  
Electrochemical Biosensing

scholarly journals Potentiostats for Protein Biosensing: Design Considerations and Analysis on Measurement Characteristics

2019 ◽  
Vol 2019 ◽  
pp. 1-20 ◽  
Author(s):  
Saad Abdullah ◽  
Sarah Tonello ◽  
Michela Borghetti ◽  
Emilio Sardini ◽  
Mauro Serpelloni
Keyword(s):  
Point Of Care ◽  
Protein Detection ◽  
Protein Quantification ◽  
Electrical Parameters ◽  
Protein Biomarkers ◽  
Analog To Digital ◽  
Design Considerations ◽  
Electrochemical Biosensing ◽  
Biochemical Assays ◽  
Reliable Quantification

The demand for the development of swift, simple, and ultrasensitive biosensors has been increasing after the introduction of innovative approaches such as bioelectronics, nanotechnology, and electrochemistry. The possibility to correlate changes in electrical parameters with the concentration of protein biomarkers in biological samples is appealing to improve sensitivity, reliability, and repeatability of the biochemical assays currently available for protein investigation. Potentiostats are the required instruments to ensure the proper cell conditioning and signal processing in accurate electrochemical biosensing applications. In this light, this review is aimed at analyzing design considerations, electrical specifications, and measurement characteristics of potentiostats, specifically customized for protein detection. This review demonstrates how a proper potentiostat for protein quantification should be able to supply voltages in a range between few mV to few V, with high resolution in terms of readable current (in the order of 100 pA). To ensure a reliable quantification of clinically relevant protein concentrations (>1 ng/mL), the accuracy of the measurement (<1%) is significant and it can be ensured with proper digital-to-analog (10-16 bits) and analog-to-digital (10-24 bits) converters. Furthermore, the miniaturisation of electrochemical systems represents a key step toward portable, real-time, and fast point-of-care applications. This review is meant to serve as a guide for the design of customized potentiostats capable of a more proper and enhanced conditioning of electrochemical biosensors for protein detection.

scholarly journals COVID-19 challenges: from SARS-CoV-2 infection to effective point-of-care diagnosis by electrochemical biosensing platforms

2021 ◽  
pp. 108200
Author(s):  
D. Campos-Ferreira ◽  
V. Visani ◽  
C Córdula ◽  
G.A. Nascimento ◽  
L.M.L. Montenegro ◽  
...  
Keyword(s):  
Point Of Care ◽  
Electrochemical Biosensing

Antifouling Strategies for Electrochemical Biosensing: Mechanisms and Performance toward Point of Care Based Diagnostic Applications

ACS Sensors ◽  
2021 ◽  
Author(s):  
Matthew J. Russo ◽  
Mingyu Han ◽  
Pauline E. Desroches ◽  
Clayton S. Manasa ◽  
Jessair Dennaoui ◽  
...  
Keyword(s):  
Point Of Care ◽  
Electrochemical Biosensing ◽  
And Performance ◽  
Diagnostic Applications

scholarly journals NANOTECHNOLOGY FOR DETECTION OF DISEASES CAUSED BY VIRUSES-CURRENT OVERVIEW

2021 ◽  
pp. 1-7
Author(s):  
SRILAXMI CHIPPA ◽  
VASANTI SUVARNA
Keyword(s):  
Fungal Pathogens ◽  
Point Of Care ◽  
Nano Particles ◽  
Nano Materials ◽  
Virus Infections ◽  
Optical Biosensing ◽  
Electrochemical Biosensing ◽  
Point Of Care Diagnostics ◽  
Immunodeficiency Virus ◽  
Detection Of Biomarkers

Nanotechnology is having a high impact on the development of a novel class of biosensors called nanobiosensors. This technology has utilized some extremely exciting elements for sensing phenomenon improvement. The utilization of nano-materials, nano-rods, nano-particles, nano-tubes have aided rapid, reliable reproducibility and its detection in a much better way. The unique properties of nanobiosensors and its varied applications have influenced biosensing research. Since longtime, nanobiosensors have been utilized worldwide for the diagnosis of diseases co-related with molecular detection of biomarkers. This paper highlights the use of such nanobiosensors for the detection of the virus, infections, fungal pathogens, Human Immunodeficiency Virus (HIV) related diseases such as Cardiovascular diseases (CDVs), Renal Arthritis (RA) through different techniques including electrochemical biosensing, optical biosensing, point of care-diagnostics etc.

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