A One-Pot Copper-Catalyzed 3-Fold C-N Bond Coupling Strategy to the Synthesis of Substituted Benzimidazoles

2020 ◽  
Author(s):  
Parthasarathi Subramanian ◽  
Krishna P. Kaliappan
Keyword(s):  
One Pot ◽  
Coupling Strategy

The synthesis of arylcyanamides: a copper-catalyzed consecutive desulfurization and C–N cross-coupling strategy

2018 ◽  
Vol 42 (2) ◽  
pp. 918-922 ◽  
Author(s):  
S. N. Murthy Boddapati ◽  
Naresh Polam ◽  
Baby Ramana Mutchu ◽  
Hari Babu Bollikolla
Keyword(s):  
Cross Coupling ◽  
One Pot ◽  
Highly Efficient ◽  
Simple Protocol ◽  
Coupling Strategy

A one pot highly efficient and simple protocol for the construction of aromatic cyanamides from thioureaviadesulphurization/C–N cross coupling using a cheap, readily available and air stable copper source as a catalyst has been described.

scholarly journals Ni-catalyzed deaminative cross-electrophile coupling of Katritzky salts with halides via C─N bond activation

2019 ◽  
Vol 5 (6) ◽  
pp. eaaw9516 ◽  
Author(s):  
Shengyang Ni ◽  
Chun-Xiao Li ◽  
Yu Mao ◽  
Jianlin Han ◽  
Yi Wang ◽  
...  
Keyword(s):  
Bond Activation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Primary Amines ◽  
One Pot ◽  
Carbon Centers ◽  
Alkyl Bromides ◽  
Wide Range ◽  
Coupling Strategy ◽  
The One

The reductive cross-coupling of sp3-hybridized carbon centers represents great synthetic values and insurmountable challenges. In this work, we report a nickel-catalyzed deaminative cross-electrophile coupling reaction to construct C(sp)─C(sp3), C(sp2)─C(sp3), and C(sp3)─C(sp3) bonds. A wide range of coupling partners including aryl iodides, bromoalkynes, or alkyl bromides are stitched with alkylpyridinium salts that derived from the corresponding primary amines. The advantages of this methodology are showcased in the two-step synthesis of the key lactonic moiety of (+)-compactin and (+)-mevinolin. The one-pot procedure without isolation of alkylpyridinium tetrafluoroborate salt is also proven to be successful. This cross-coupling strategy of two electrophiles provides a highly valuable vista for the convenient installation of alkyl substituents and late functionalizations of sp3 carbons.

scholarly journals A modular phosphate tether-mediated divergent strategy to complex polyols

2014 ◽  
Vol 10 ◽  
pp. 2332-2337 ◽  
Author(s):  
Paul R Hanson ◽  
Susanthi Jayasinghe ◽  
Soma Maitra ◽  
Cornelius N Ndi ◽  
Rambabu Chegondi
Keyword(s):  
Reduction Process ◽  
Phosphoryl Chloride ◽  
One Pot ◽  
Simple Order ◽  
Coupling Strategy ◽  
Phosphate Tether

An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pseudo-C 2-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.

Biginelli reaction beyond three-component limit: synthesis of functionalized pyrimidinones via a one-pot Biginelli-Pd mediated C–C coupling strategy

2011 ◽  
Vol 52 (11) ◽  
pp. 1187-1191 ◽  
Author(s):  
P. Mahesh Kumar ◽  
K. Siva Kumar ◽  
Srinivas Reddy Poreddy ◽  
Pradeep Kumar Mohakhud ◽  
K. Mukkanti ◽  
...  
Keyword(s):  
Biginelli Reaction ◽  
One Pot ◽  
Coupling Strategy

Direct access to benzo[b]fluorenes via a gold-catalysed A3-coupling strategy

2019 ◽  
Vol 6 (10) ◽  
pp. 1655-1662 ◽  
Author(s):  
Danilo M. Lustosa ◽  
Patrick Cieslik ◽  
Deborah Hartmann ◽  
Tim Bruckhoff ◽  
Matthias Rudolph ◽  
...  
Keyword(s):  
Gold Catalysis ◽  
Direct Access ◽  
Thermal Cyclization ◽  
One Pot ◽  
Coupling Strategy ◽  
A3 Coupling

A one-pot combination of gold catalysis and thermal cyclization provides a fast convergent route to benzo[b]fluorenes.

Copper(II) Catalyzed Expeditious Synthesis of Furoquinoxalines through a One-Pot Three-Component Coupling Strategy

2014 ◽  
Vol 16 (17) ◽  
pp. 4528-4531 ◽  
Author(s):  
Gunaganti Naresh ◽  
Ruchir Kant ◽  
Tadigoppula Narender
Keyword(s):  
One Pot ◽  
Coupling Strategy ◽  
Three Component Coupling

Azacalix[2]arene[2]carbazoles: synthesis, structure and properties

RSC Advances ◽  
2016 ◽  
Vol 6 (33) ◽  
pp. 27988-27992 ◽  
Author(s):  
Hui Xu ◽  
Fang-Jun Qian ◽  
Qiao-Xia Wu ◽  
Min Xue ◽  
Yong Yang ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Structure And Properties ◽  
Aromatic Nucleophilic Substitution ◽  
One Pot ◽  
Coupling Strategy ◽  
New Type ◽  
Aromatic Nucleophilic Substitution Reaction

A new type of –NH– bridged azacalix[2]arene[2]carbazoles has been synthesized by aromatic nucleophilic substitution reactionviaone pot and/or fragment coupling strategy.

A Cascade Coupling Strategy for One-Pot Total Synthesis of β-Carboline and Isoquinoline-Containing Natural Products and Derivatives

2013 ◽  
Vol 19 (31) ◽  
pp. 10132-10137 ◽  
Author(s):  
Yan-Ping Zhu ◽  
Mei-Cai Liu ◽  
Qun Cai ◽  
Feng-Cheng Jia ◽  
An-Xin Wu
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
One Pot ◽  
Coupling Strategy
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