Recent Progress in the Synthesis of Naturally Occurring Siderophores

2019 ◽  
Vol 2019 (48) ◽  
pp. 7747-7769 ◽  
Author(s):  
Fabián Garzón-Posse ◽  
Yovanny Quevedo-Acosta ◽  
Camilo Mahecha-Mahecha ◽  
Paola Acosta-Guzmán
Keyword(s):  
Recent Progress ◽  
Naturally Occurring

The Modification and Design of Antimicrobial Peptide

2018 ◽  
Vol 24 (8) ◽  
pp. 904-910 ◽  
Author(s):  
Yidan Gao ◽  
Hengtong Fang ◽  
Lu Fang ◽  
Dawei Liu ◽  
Jinsong Liu ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Antimicrobial Peptide ◽  
Protein Modification ◽  
Recent Progress ◽  
Therapeutic Agents ◽  
Manufacturing Cost ◽  
Commercial Development ◽  
Biochemical Modification ◽  
Naturally Occurring ◽  
Application Prospects

The antimicrobial peptides (AMPs) are a group of unique naturally occurring anti-microbial compounds with around 50 amino acids. It represents promising therapeutic agents to the infectious disease without concerning about drug resistance. However, commercial development of these peptides for even the simplest application has been hindered by the limitations of sources, instability, toxicity and bioavailability. To improve the properties of the artificial synthesized AMPs, the modification and design are the hotspots of the AMPs research. In fact, more than half of the known AMPs are naturally modified. In this review, two types of modification strategies, biochemical modification and chemical modification were summarized. Although, the chemical modification is versatile and direct, the manufacturing cost is greatly increased compared to the antibiotics. With the recent progress of the protein modification enzyme, the biochemical modification of the antimicrobial peptide followed by heterologous expression has great application prospects.

scholarly journals Myco-Biocontrol of Insect Pests: Factors Involved, Mechanism, and Regulation

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Sardul Singh Sandhu ◽  
Anil K. Sharma ◽  
Vikas Beniwal ◽  
Gunjan Goel ◽  
Priya Batra ◽  
...  
Keyword(s):  
Biological Control ◽  
Recent Progress ◽  
Insect Pests ◽  
Insect Pest ◽  
Past Research ◽  
Attractive Alternative ◽  
Insect Pest Control ◽  
Naturally Occurring ◽  
Chemical Inputs ◽  
Chemical Pesticides

The growing demand for reducing chemical inputs in agriculture and increased resistance to insecticides have provided great impetus to the development of alternative forms of insect-pest control. Myco-biocontrol offers an attractive alternative to the use of chemical pesticides. Myco-biocontrol agents are naturally occurring organisms which are perceived as less damaging to the environment. Their mode of action appears little complex which makes it highly unlikely that resistance could be developed to a biopesticide. Past research has shown some promise of the use of fungi as a selective pesticide. The current paper updates us about the recent progress in the field of myco-biocontrol of insect pests and their possible mechanism of action to further enhance our understanding about the biological control of insect pests.

scholarly journals Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides

2014 ◽  
Vol 35 (3) ◽  
pp. 316-330 ◽  
Author(s):  
Jing Xu ◽  
Cheng-shi Jiang ◽  
Zai-long Zhang ◽  
Wen-quan Ma ◽  
Yue-wei Guo
Keyword(s):  
Recent Progress ◽  
Naturally Occurring

Recent progress in the field of neoglycoconjugate chemistry

2010 ◽  
Vol 1 (1) ◽  
pp. 85-96
Author(s):  
Carmen Jiménez-Castells ◽  
Sira Defaus ◽  
David Andreu ◽  
Ricardo Gutiérrez-Gallego
Keyword(s):  
Amino Acid ◽  
Recent Progress ◽  
Heterogeneous Mixture ◽  
Naturally Occurring ◽  
Single Protein ◽  
Recent Developments

AbstractGlycosylation is probably the most complex secondary gene event that affects the vast majority of proteins in nature resulting in the occurrence of a heterogeneous mixture of glycoforms for a single protein. Many functions are exerted by single monosaccharides, well-defined oligosaccharides, or larger glycans present in these glycoproteins. To unravel these functions it is of the utmost importance to prepare well-defined single glycans conjugated to the underlying aglycon. In this review, the most recent developments are described to address the preparation of carbohydrate-amino acid (glyco-conjugates). Naturally occurring N- and O-linked glycosylation are described and the preparation of non-natural sugar-amino acid linkages are also included.

Naturally occurring [4 + 2] type terpenoid dimers: sources, bioactivities and total syntheses

2020 ◽  
Vol 37 (12) ◽  
pp. 1627-1660
Author(s):  
Bo Liu ◽  
Shaomin Fu ◽  
Chengying Zhou
Keyword(s):  
Recent Progress ◽  
Review Article ◽  
Total Syntheses ◽  
Naturally Occurring

This review article highlights recent progress on their sources, bioactivities, biosynthetic hypotheses and total chemical syntheses of naturally occurring [4 + 2] type terpenoid dimers.

ChemInform Abstract: Recent Progress in the Synthesis of Naturally Occurring Triterpenoid Saponins

ChemInform ◽  
2010 ◽  
Vol 41 (23) ◽  
pp. no-no
Author(s):  
Charles Gauthier ◽  
Jean Legault ◽  
Andre Pichette
Keyword(s):  
Recent Progress ◽  
Triterpenoid Saponins ◽  
Naturally Occurring

Recent Progress in the Synthesis of Naturally Occurring Triterpenoid Saponins

2009 ◽  
Vol 6 (4) ◽  
pp. 321-344 ◽  
Author(s):  
Charles Gauthier ◽  
Jean Legault ◽  
Andre Pichette
Keyword(s):  
Recent Progress ◽  
Triterpenoid Saponins ◽  
Naturally Occurring

Enantioselective Bromocyclization of Allylic Amides Mediated by Phosphorus Catalysis

Synlett ◽  
2018 ◽  
Vol 29 (10) ◽  
pp. 1257-1271 ◽  
Author(s):  
Yoshitaka Hamashima ◽  
Yuji Kawato
Keyword(s):  
Recent Progress ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Fine Tuning ◽  
Hiv Protease ◽  
Naturally Occurring ◽  
Molecular Complexity ◽  
Tuning Element ◽  
Remarkable Progress ◽  
Comprehensive Study

Halocyclization of alkenes is commonly employed to increase molecular complexity during organic synthesis because it enables double installation of heteroatoms on a carbon–carbon double bond. Moreover, stereodefined halogenated compounds are widely found among naturally occurring compounds and can serve as versatile chiral building blocks. Therefore, the development of asymmetric halocyclization reactions is of great interest and, in recent years, there has been remarkable progress in catalytic asymmetric halogenation reactions. This account summarizes recent progress made by our group on phosphorus-­catalyzed enantioselective bromocyclization of allylic amides. Building on a comprehensive study of the reaction mechanism, we discovered an intriguing catalytic reaction in which P+Br species serves as a fine-tuning element for substrate fixation. We also describe the application of this bromocyclization to asymmetric desymmetrization of 1,4-diene substrates and a concise synthesis of the HIV-protease inhibitor ­nelfinavir using the newly developed desymmetrization reaction as a key step.1 Introduction2 Enantioselective Bromocyclization of Allylic Amides with a BINAP Catalyst2.1 Bromocyclization with a P/P Catalyst2.2 Bromocyclization with a P/P=O Catalyst3 Desymmetrization of Bisallylic Amides through Enantioselective Bromocyclization3.1 Desymmetrization of Bisallylic Amides3.2 Enantioselective Synthesis of Nelfinavir4 Summary

Recent Progress on the Synthesis and Bioactivity of Marine Naturally Occurring Dienamides and Related Derivatives

2015 ◽  
Vol 45 (19) ◽  
pp. 2159-2180 ◽  
Author(s):  
Yan-Ling Zhang ◽  
Ya-Fei Li ◽  
Bin Yu ◽  
Li-Hong Shan ◽  
Hong-Min Liu
Keyword(s):  
Recent Progress ◽  
Naturally Occurring

ChemInform Abstract: Recent Progress on the Synthesis and Bioactivity of Marine Naturally Occurring Dienamides and Related Derivatives

ChemInform ◽  
2015 ◽  
Vol 46 (45) ◽  
pp. no-no
Author(s):  
Yan-Ling Zhang ◽  
Ya-Fei Li ◽  
Bin Yu ◽  
Li-Hong Shan ◽  
Hong-Min Liu
Keyword(s):  
Recent Progress ◽  
Naturally Occurring
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