Peptide Functionalization Through the Generation of Selenocysteine Electrophile

2019 ◽  
Vol 2019 (30) ◽  
pp. 4951-4961 ◽  
Author(s):  
Pavel Arsenyan ◽  
Sindija Lapcinska ◽  
Anna Ivanova ◽  
Jelena Vasiljeva
Keyword(s):  
Peptide Functionalization

scholarly journals Investigating surface topology and cyclic-RGD peptide functionalization on vascular endothelialization

2013 ◽  
Vol 102 (2) ◽  
pp. 532-539 ◽  
Author(s):  
Colton McNichols ◽  
Justin Wilkins ◽  
Atsutoshi Kubota ◽  
Yan T. Shiu ◽  
Samir M. Aouadi ◽  
...  
Keyword(s):  
Rgd Peptide ◽  
Surface Topology ◽  
Peptide Functionalization

scholarly journals From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1492
Author(s):  
Francisco G. Blanco ◽  
Natalia Hernández ◽  
Virginia Rivero-Buceta ◽  
Beatriz Maestro ◽  
Jesús M. Sanz ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Carbon Sources ◽  
Structural Diversity ◽  
Added Value ◽  
Nanoscale Systems ◽  
Chemical Structures ◽  
Wide Range ◽  
Peptide Functionalization ◽  
Metabolic Strategies ◽  
Drug Nanocarriers

Bacterial biopolymers are naturally occurring materials comprising a wide range of molecules with diverse chemical structures that can be produced from renewable sources following the principles of the circular economy. Over the last decades, they have gained substantial interest in the biomedical field as drug nanocarriers, implantable material coatings, and tissue-regeneration scaffolds or membranes due to their inherent biocompatibility, biodegradability into nonhazardous disintegration products, and their mechanical properties, which are similar to those of human tissues. The present review focuses upon three technologically advanced bacterial biopolymers, namely, bacterial cellulose (BC), polyhydroxyalkanoates (PHA), and γ-polyglutamic acid (PGA), as models of different carbon-backbone structures (polysaccharides, polyesters, and polyamides) produced by bacteria that are suitable for biomedical applications in nanoscale systems. This selection models evidence of the wide versatility of microorganisms to generate biopolymers by diverse metabolic strategies. We highlight the suitability for applied sustainable bioprocesses for the production of BC, PHA, and PGA based on renewable carbon sources and the singularity of each process driven by bacterial machinery. The inherent properties of each polymer can be fine-tuned by means of chemical and biotechnological approaches, such as metabolic engineering and peptide functionalization, to further expand their structural diversity and their applicability as nanomaterials in biomedicine.

scholarly journals Covalent Graft of Lipopeptides and Peptide Dendrimers to Cellulose Fibers

Coatings ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 606 ◽  
Author(s):  
Andrea Orlandin ◽  
Paolo Dolcet ◽  
Barbara Biondi ◽  
Geta Hilma ◽  
Diana Coman ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Antimicrobial Agents ◽  
Cellulose Fibers ◽  
Specific Weight ◽  
Amide Bond ◽  
Covalent Attachment ◽  
Peptide Dendrimers ◽  
Two Samples ◽  
Covalently Linked ◽  
Peptide Functionalization

Introduction: Bacterial proliferation in health environments may lead to the development of specific pathologies, but can be highly dangerous under particular conditions, such as during chemotherapy. To limit the spread of infections, it is helpful to use gauzes and clothing containing antibacterial agents. As cotton tissues are widespread in health care environments, in this contribution we report the preparation of cellulose fibers characterized by the covalent attachment of lipopeptides as possible antimicrobial agents. Aim: To covalently link peptides to cotton samples and characterize them. Peptides are expected to preserve the features of the fabrics even after repeated washing and use. Peptides are well tolerated by the human body and do not induce resistance in bacteria. Materials and Methods: A commercially available cotton tissue (specific weight of 150 g/m2, 30 Tex yarn fineness, fabric density of 270/230 threads/10 cm in the warp and weft) was washed with alkali and bleached and died. A piece of this tissue was accurately weighed, washed with methanol (MeOH) and N,N-dimethylformamide (DMF), and air-dried. Upon incubation with epibromohydrin, followed by treatment with Fmoc-NH-CH2CH2-NH2 and Fmoc removal, the peptides were synthesized by incorporating one amino acid at a time, beginning with the formation of an amide bond with the free NH2 of 1,2–diaminoethane. We also linked to the fibers a few peptide dendrimers, because the mechanism of action of these peptides often requires the formation of clusters. We prepared and characterized seven peptide-cotton samples. Results: The new peptide-cotton conjugates were characterized by means of FT-IR spectroscopy and X-ray Photoelectron Spectroscopy (XPS). This latter technique allows for discriminating among different amino acids and thus different peptide-cotton samples. Some samples maintain a pretty good whiteness degree even after peptide functionalization. Interestingly, these samples also display encouraging activities against a Gram positive strain. Conclusions: Potentially antimicrobial lipopeptides can be covalently linked to cotton fabrics, step-by-step. It is also possible to build on the cotton Lys-based dendrimers. XPS is a useful technique to discriminate among different types of nitrogen. Two samples displaying some antibacterial potency did also preserve their whiteness index.

Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics

2015 ◽  
Vol 36 (17) ◽  
pp. 1559-1565 ◽  
Author(s):  
Liye Yang ◽  
Wenying Li ◽  
Yanyu Huang ◽  
Yangliang Zhou ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Rgd Peptide ◽  
Cancer Theranostics ◽  
Peptide Functionalization

Surface peptide functionalization of zeolitic imidazolate framework-8 for autonomous homing and enhanced delivery of chemotherapeutic agent to lung tumor cells

2021 ◽  
Vol 50 (7) ◽  
pp. 2375-2386
Author(s):  
Nurul Akmarina Mohd Abdul Kamal ◽  
Emilia Abdulmalek ◽  
Sharida Fakurazi ◽  
Kyle E. Cordova ◽  
Mohd Basyaruddin Abdul Rahman
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Chemotherapeutic Agent ◽  
Lung Tumor ◽  
One Pot ◽  
Zeolitic Imidazolate Framework ◽  
Peptide System ◽  
Homing Peptide ◽  
Peptide Functionalization

This work demonstrates a new one-pot strategy for realizing a surface-functionalized zeolitic imidazolate framework that actively targets cancer cells via an autonomous homing peptide system to deliver a chemotherapeutic payload effectively.

Sign in / Sign up

Export Citation Format

Share Document