Catalytic and Chemoselective Oxidation of Activated Alcohols and Direct Conversion of Diols to Lactones with In Situ-Generated Bis-IBX Catalyst

2013 ◽  
Vol 2013 (12) ◽  
pp. 2445-2452 ◽  
Author(s):  
Saona Seth ◽  
Samik Jhulki ◽  
Jarugu Narasimha Moorthy
Keyword(s):  
Direct Conversion

scholarly journals Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source

2018 ◽  
Author(s):  
Yohei Ogiwara ◽  
Ken Takano ◽  
Shuhei Horikawa ◽  
Norio Sakai
Keyword(s):  
Elemental Sulfur ◽  
Direct Conversion ◽  
Pharmaceutical Chemistry ◽  
Sulfur Source ◽  
Efficient Synthesis ◽  
Previous Reaction ◽  
Indium Catalyst

Indium-catalyzed reaction of lactones and a disilathiane leading to thiolactones is described. The direct synthesis of thiolactones from lactones with an appropriate sulfur source is one of the most attractive approaches in organic and pharmaceutical chemistry. In this context, we found an indium-catalyzed direct conversion of lactones into thiolactones in the presence of elemental sulfur and a hydrosilane via formation of the disilathiane in-situ. On the basis of the previous reaction, the application utilizing the disilathiane as a sulfur source was performed herein for the efficient synthesis of a variety of thiolactone derivatives from lactones by an indium-catalyst.

Direct conversion of coordination compounds into Ni2P nanoparticles entrapped in 3D mesoporous graphene for an efficient hydrogen evolution reaction

2017 ◽  
Vol 1 (5) ◽  
pp. 973-978 ◽  
Author(s):  
Sungeun Jeoung ◽  
Bora Seo ◽  
Jeong Min Hwang ◽  
Sang Hoon Joo ◽  
Hoi Ri Moon
Keyword(s):  
Hydrogen Evolution ◽  
Hydrogen Evolution Reaction ◽  
Coordination Compounds ◽  
Direct Conversion

5 nm-sized Ni2P nanoparticles entrapped in 3D mesoporous graphene (Ni2P@mesoG) were synthesized in situ via [Ni2(EDTA)] thermolysis, followed by phosphidation.

A synergetic effect of ionic liquid and microwave irradiation on the acid-catalyzed direct conversion of cellulose into methyl glucopyranoside

Holzforschung ◽  
2018 ◽  
Vol 72 (12) ◽  
pp. 1025-1030
Author(s):  
Mafuyu Saito ◽  
Takao Kishimoto ◽  
Masahiro Hamada ◽  
Noriyuki Nakajima ◽  
Daisuke Urabe
Keyword(s):  
Ionic Liquid ◽  
Microwave Irradiation ◽  
Synergetic Effect ◽  
Acid Catalyst ◽  
Solvent System ◽  
Direct Conversion ◽  
Important Research Topic ◽  
Acid Catalyzed ◽  
Methyl Pyrrolidone

AbstractConversion of lignocellulose into useful chemicals is an important research topic in the area of biomass utilization. In this study, microcrystalline cellulose (MC) was dissolved in a mixed-solvent system containing the ionic liquid (IL) 1-allyl-3-methylimidazolium chloride ([Amim]Cl) andN-methyl-pyrrolidone (NMP), and the cellulose was directly converted into methyl glucoside (MG) by acid-catalyzed methanolysis aided by microwave irradiation (μWIr). Under moderate reaction temperature and pressure, and in the presence of acetyl chloride/methanol (in situformed HCl) as an acid catalyst, MG was obtained in a 42% yield. In contrast, in the absence of either IL or μWIr, the MG yield was only 5 or 21%, respectively. Both μWIr and the dissolution of cellulose in IL were quite effective for the conversion of cellulose into MG.

scholarly journals Nucleic Acid Related Compounds. 8. Direct Conversion of 2′-Deoxyinosine to 6-Chloropurine 2′-Deoxyriboside and Selected 6-Substituted Deoxynucleosides and Their Evaluation As Substrates of Adenosine Deaminase

1973 ◽  
Vol 51 (19) ◽  
pp. 3161-3169 ◽  
Author(s):  
Morris J. Robins ◽  
Gerald L. Basom
Keyword(s):  
Adenosine Deaminase ◽  
Methylene Chloride ◽  
Potassium Fluoride ◽  
Direct Conversion ◽  
Chloride Complex ◽  
High Yield ◽  
Mass Spectral ◽  
Quaternary Ammonium Chloride ◽  
Related Compounds

Trifluoroacetylation of 2′-deoxyinosine (2), obtained by enzymatic deamination of 2′-deoxyadenosine (1), gave the 3′,5′-bis-O-trifluoroacetate (3). Reaction of the electronegatively substituted deoxynucleoside, 3, with DMF-thionyl chloride complex in refluxing methylene chloride gave a high yield of 6-chloropurine 2′-deoxyriboside (4) after deblocking.Displacement of chloride of 4 by hydrosulfide to give 6-mercaptopurine 2′-deoxyriboside (5) followed by sulfur alkylation with p-nitrobenzyl bromide gave 6-S-(p-nitrobenzyl) thiopurine 2′-deoxyriboside (6) which was alternatively prepared by displacement of chloride from 4 by p-nitrobenzyl mercaptide, generated in situ from the isothiouronium salt. Methyl mercaptide reaction with 4 gave 6-methylthiopurine 2′-deoxyriboside (7). Treatment of 4 with trimethylamine gave the corresponding quaternary ammonium chloride (8) which was allowed to react with potassium fluoride to give 6-fluoropurine 2′-deoxyriboside (9). Respective amine displacements on 4 gave 6-benzylaminopurine 2'-deoxyriboside (10), and 6-hydroxylaminopurine 2′-deoxyriboside (11). Reaction of 4 with liquid ammonia completed the first reported transformation of 2′-deoxyinosine (2) to 2′-deoxyadenosine (1).Biological rationale for the synthesis of these 2′-deoxynucleosides and their evaluation as substrates of adenosine deaminase are discussed. Major mass spectral fragmentations are tabulated.

Hepatic intralobular mapping of fructose metabolism in the rat liver

2000 ◽  
Vol 349 (2) ◽  
pp. 539-545 ◽  
Author(s):  
Shamus P. BURNS ◽  
Helena C. MURPHY ◽  
Richard A. ILES ◽  
Rosemary A. BAILEY ◽  
Robert D. COHEN
Keyword(s):  
31P Nmr ◽  
Direct Conversion ◽  
31P Nmr Spectroscopy ◽  
Lactate Metabolism ◽  
Hepatic Lobule ◽  
Lactate Output ◽  
Lactate Uptake ◽  
Rat Livers ◽  
Substantial Extent

Detailed mapping of glucose and lactate metabolism along the radius of the hepatic lobule was performed in situ in rat livers perfused with 1.5 mM lactate before and during the addition of 5 mM fructose. The majority of fructose uptake occurred in the periportal region; 45% of fructose taken up in the periportal half of the lobular volume being converted into glucose. Periportal lactate uptake was markedly decreased by addition of fructose. Basal perivenous lactate output, which was derived from glucose synthesized periportally, was increased in the presence of fructose. During fructose infusion there was a small decrease in cell pH periportally, but acidification of up to 0.5 pH units perivenously. The evidence suggests that in situ the apparent direct conversion of fructose into lactate represents, to a substantial extent, the result of periportal conversion of fructose into glucose and the subsequent uptake and glycolysis to lactate in the perivenous zone of some of that glucose. 31P NMR spectroscopy showed that the cellular concentration of phosphomonoesters changes very little periportally during fructose infusion, but there was an approximate twofold increase perivenously, presumably due to the accumulation of fructose 1-phosphate. It may be inferred that fructokinase activity is expressed throughout the hepatic lobule.

A straightforward and versatile protocol for the direct conversion of benzylic azides to ketones and aldehydes

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 83547-83550 ◽  
Author(s):  
Davir González-Calderón ◽  
Marco A. Morales-Reza ◽  
Eduardo Díaz-Torres ◽  
Aydeé Fuentes-Benítes ◽  
Carlos González-Romero
Keyword(s):  
Simple Procedure ◽  
Direct Conversion ◽  
Azido Group ◽  
Rapid Hydrolysis

We report that the benzyl azido group is directly converted to carbonyls in good yields through a rapid hydrolysis (basic conditions) of benzylideneamides generated readily/efficiently in situ under a very simple procedure involving conventional reagents.

scholarly journals Selective conversion of alcohols in water to carboxylic acids by in situ generated ruthenium trans dihydrido carbonyl PNP complexes

2014 ◽  
Vol 43 (46) ◽  
pp. 17248-17254 ◽  
Author(s):  
Jong-Hoo Choi ◽  
Leo E. Heim ◽  
Mike Ahrens ◽  
Martin H. G. Prechtl
Keyword(s):  
Carboxylic Acids ◽  
Direct Conversion ◽  
Primary Alcohols ◽  
Selective Conversion ◽  
Conversion Of Alcohols

In this work, we present a mild method for direct conversion of primary alcohols into carboxylic acids with the use of water as an oxygen source.

scholarly journals Mechanochemical Knoevenagel condensation investigated in situ

2017 ◽  
Vol 13 ◽  
pp. 2010-2014 ◽  
Author(s):  
Sebastian Haferkamp ◽  
Franziska Fischer ◽  
Werner Kraus ◽  
Franziska Emmerling
Keyword(s):  
Knoevenagel Condensation ◽  
Direct Conversion ◽  
Milling Process ◽  
X Ray Diffraction ◽  
Time Resolved ◽  
X Ray ◽  
In Situ Data ◽  
Solvent Free Conditions ◽  
Yield Time

The mechanochemical Knoevenagel condensation of malononitrile with p-nitrobenzaldehyde was studied in situ using a tandem approach. X-ray diffraction and Raman spectroscopy were combined to yield time-resolved information on the milling process. Under solvent-free conditions, the reaction leads to a quantitative conversion to p-nitrobenzylidenemalononitrile within 50 minutes. The in situ data indicate that the process is fast and proceeds under a direct conversion. After stopping the milling process, the reaction continues until complete conversion. The continuous and the stopped milling process both result in crystalline products suitable for single crystal X-ray diffraction.

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