Asymmetric Michael Addition Reactions between 3-Substituted Benzofuran-2(3H)-ones and 1,1-Bis(phenylsulfonyl)ethylene Catalyzed by Bifunctional Catalysts Containing Tertiary Amine and Thiourea Groups

2012 ◽  
Vol 2012 (9) ◽  
pp. 1774-1782 ◽  
Author(s):  
Xin Li ◽  
Yue-Yan Zhang ◽  
Xiao-Song Xue ◽  
Jia-Lu Jin ◽  
Bo-Xuan Tan ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Addition Reactions ◽  
Bifunctional Catalysts ◽  
Asymmetric Michael Addition

Theoretical studies on the activation mechanism involving bifunctional tertiary amine–thioureas and isatylidene malononitriles

RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 34314-34318 ◽  
Author(s):  
Zheng-Hang Qi ◽  
Ye Zhang ◽  
Gui-Yu Ruan ◽  
Yi Zhang ◽  
Yong Wang ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Activation Mechanism ◽  
Addition Reactions ◽  
Theoretical Studies ◽  
Dft Studies ◽  
The Michael Addition

DFT studies on the activation mechanism of the Michael addition reactions containing bifunctional tertiary amine–thioureas and isatylidene malononitriles have been performed at the B3LYP/6-311++G(d,p)//B3LYP/6-31G(d) level of theory.

Asymmetric Michael addition between kojic acid derivatives and unsaturated ketoesters promoted by C2-symmetric organocatalysts

2018 ◽  
Vol 16 (48) ◽  
pp. 9314-9318 ◽  
Author(s):  
Alexey A. Kostenko ◽  
Alexander S. Kucherenko ◽  
Andrey N. Komogortsev ◽  
Boris V. Lichitsky ◽  
Sergei G. Zlotin
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Kojic Acid ◽  
Domino Reaction ◽  
Asymmetric Michael Addition

An efficient C2-symmetric bifunctional tertiary amine–squaramide organocatalyst for the asymmetric Michael addition/hemiketalization domino reaction of kojic acid derivatives with β,γ-unsaturated α-ketoesters has been designed.

Novel ferrocene-based bifunctional amine–thioureas for asymmetric Michael addition of acetylacetone to nitroolefins

2015 ◽  
Vol 13 (17) ◽  
pp. 5054-5060 ◽  
Author(s):  
Xiaochen Ren ◽  
Chunyan He ◽  
Yingle Feng ◽  
Yonghai Chai ◽  
Wei Yao ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Efficient Method ◽  
Michael Addition ◽  
High Yield ◽  
Bifunctional Catalysts ◽  
Michael Adducts ◽  
Asymmetric Michael Addition ◽  
Multiple Hydrogen Bonding

An efficient method was developed to synthesize the ferrocene-based bifunctional amine–thioureas bearing multiple hydrogen-bonding donors. Asymmetric Michael addition of acetylacetone to nitroolefins catalyzed by these novel bifunctional catalysts affords the Michael adducts in high yield and moderate to excellent enantioselectivities.

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