In Situ Preparation of Chiral Bifunctional Catalysts and Their Application to Asymmetric Michael Addition Reactions

2012 ◽  
Vol 1 (1) ◽  
pp. 26-29
Author(s):  
Shin A. Moteki ◽  
Peter Gakio Kirira ◽  
Satoru Arimitsu ◽  
Keiji Maruoka
Keyword(s):  
Michael Addition ◽  
Addition Reactions ◽  
Bifunctional Catalysts ◽  
In Situ Preparation ◽  
Asymmetric Michael Addition

Dearomatization-Rearomatization Strategy of Tyrosine for Peptides/Protein Modification through Thiol-Addition Reactions

2021 ◽  
Author(s):  
Pengxin Wang ◽  
Yulian Cheng ◽  
Chunlei Wu ◽  
Ruixiang Luo ◽  
Caibin Ma ◽  
...  
Keyword(s):  
Michael Addition ◽  
Protein Modification ◽  
Addition Reactions

We have developed a dearomatization-rearomatization strategy for modification of peptides/protein through thiol-Michael addition to the electrophilic cyclohexadienone intermediate in situ generated by oxidation of tyrosine. This strategy enriches the conjugation...

Novel ferrocene-based bifunctional amine–thioureas for asymmetric Michael addition of acetylacetone to nitroolefins

2015 ◽  
Vol 13 (17) ◽  
pp. 5054-5060 ◽  
Author(s):  
Xiaochen Ren ◽  
Chunyan He ◽  
Yingle Feng ◽  
Yonghai Chai ◽  
Wei Yao ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Efficient Method ◽  
Michael Addition ◽  
High Yield ◽  
Bifunctional Catalysts ◽  
Michael Adducts ◽  
Asymmetric Michael Addition ◽  
Multiple Hydrogen Bonding

An efficient method was developed to synthesize the ferrocene-based bifunctional amine–thioureas bearing multiple hydrogen-bonding donors. Asymmetric Michael addition of acetylacetone to nitroolefins catalyzed by these novel bifunctional catalysts affords the Michael adducts in high yield and moderate to excellent enantioselectivities.

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