A Novel Approach to the Practical Synthesis of Sulfides: An InBr3-Et3SiH Catalytic System Promoted the Direct Reductive Sulfidation of Acetals with Disulfides

2009 ◽  
Vol 2009 (24) ◽  
pp. 4123-4127 ◽  
Author(s):  
Norio Sakai ◽  
Kohei Moritaka ◽  
Takeo Konakahara
Keyword(s):  
Catalytic System ◽  
Novel Approach ◽  
Practical Synthesis

ChemInform Abstract: Practical Synthesis of the Rebeccamycin Aglycone and Related Analogues by Oxidative Cyclization of Bisindolylmaleimides with a Wacker-Type Catalytic System.

ChemInform ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. no-no
Author(s):  
Jianji Wang ◽  
Miguel Rosingana ◽  
Daniel J. Watson ◽  
Eric D. Dowdy ◽  
Robert P. Discordia ◽  
...  
Keyword(s):  
Catalytic System ◽  
Oxidative Cyclization ◽  
Practical Synthesis

Practical synthesis of the rebeccamycin aglycone and related analogs by oxidative cyclization of bisindolylmaleimides with a Wacker-type catalytic system

2001 ◽  
Vol 42 (51) ◽  
pp. 8935-8937 ◽  
Author(s):  
Jianji Wang ◽  
Miguel Rosingana ◽  
Daniel J Watson ◽  
Eric D Dowdy ◽  
Robert P Discordia ◽  
...  
Keyword(s):  
Catalytic System ◽  
Oxidative Cyclization ◽  
Practical Synthesis

scholarly journals One-pot sequential synthesis of tetrasubstituted thiophenes via sulfur ylide-like intermediates

2018 ◽  
Vol 14 ◽  
pp. 243-252 ◽  
Author(s):  
Jun Ki Kim ◽  
Hwan Jung Lim ◽  
Kyung Chae Jeong ◽  
Seong Jun Park
Keyword(s):  
Methoxy Group ◽  
Meldrum's Acid ◽  
Structural Effects ◽  
Meldrum’S Acid ◽  
Nmr Studies ◽  
One Pot ◽  
H Nmr ◽  
Novel Approach ◽  
Sulfur Ylide ◽  
Practical Synthesis

Herein, we describe a novel approach for the practical synthesis of tetrasubstituted thiophenes 8. The developed method was particularly used for the facile preparation of thienyl heterocycles 8. The mechanism for this reaction is based on the formation of a sulfur ylide-like intermediate. It was clearly suggested by (i) the intramolecular cyclization of ketene N,S-acetals 7 to the corresponding thiophenes 8, (ii) 1H NMR studies of Meldrum’s acid-substituted aminothioacetals 9, and (iii) substitution studies of the methoxy group on Meldrum’s acid containing N,S-acetals 9b. Notably, in terms of structural effects on the reactivity and stability of sulfur ylide-like intermediates, 2-pyridyl substituted compound 7a exhibited superior properties over those of others.

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