ChemInform Abstract: Practical Synthesis of the Rebeccamycin Aglycone and Related Analogues by Oxidative Cyclization of Bisindolylmaleimides with a Wacker-Type Catalytic System.

ChemInform ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. no-no
Author(s):  
Jianji Wang ◽  
Miguel Rosingana ◽  
Daniel J. Watson ◽  
Eric D. Dowdy ◽  
Robert P. Discordia ◽  
...  
Keyword(s):  
Catalytic System ◽  
Oxidative Cyclization ◽  
Practical Synthesis

Practical synthesis of the rebeccamycin aglycone and related analogs by oxidative cyclization of bisindolylmaleimides with a Wacker-type catalytic system

2001 ◽  
Vol 42 (51) ◽  
pp. 8935-8937 ◽  
Author(s):  
Jianji Wang ◽  
Miguel Rosingana ◽  
Daniel J Watson ◽  
Eric D Dowdy ◽  
Robert P Discordia ◽  
...  
Keyword(s):  
Catalytic System ◽  
Oxidative Cyclization ◽  
Practical Synthesis

Heterogeneous Copper(I)-Catalyzed Cascade Addition–Oxidative Cyclization of Nitriles with 2-Aminopyridines or Amidines: Efficient and Practical Synthesis of 1,2,4-Triazoles

Synthesis ◽  
2019 ◽  
Vol 51 (09) ◽  
pp. 2014-2022 ◽  
Author(s):  
Jianhui Xia ◽  
Xue Huang ◽  
Mingzhong Cai
Keyword(s):  
Catalytic Activity ◽  
Oxidative Cyclization ◽  
Triazole Derivatives ◽  
Step Procedure ◽  
Practical Synthesis ◽  
High Yields ◽  
Mcm 41

The heterogeneous cascade addition-oxidative cyclization of nitriles with 2-aminopyridines or amidines was achieved in 1,2-dichlorobenzene or DMSO at 120–130 °C by using a 1,10-phenanthroline-functionalized MCM-41-supported copper(I) complex [Phen-MCM-41-CuBr] as the catalyst and air as the oxidant. The approach was used to generate a wide variety of 1,2,4-triazole derivatives in mostly high yields. This heterogeneous copper(I) catalyst could be easily prepared in a two-step procedure from commercially or readily available and inexpensive reagents and it exhibited higher catalytic activity than the CuBr/1,10-Phen system. Phen-MCM-41-CuBr was also easy to recover and was recyclable up to eight times with almost consistent activity.

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