scholarly journals Metal Anticancer Complexes - Activity, Mechanism of Action, Future Perspectives

2017 ◽  
Vol 2017 (12) ◽  
pp. 1539-1540 ◽  
Author(s):  
Enzo Alessio ◽  
Zijian Guo
Keyword(s):  
Mechanism Of Action ◽  
Future Perspectives ◽  
Anticancer Complexes ◽  
Activity Mechanism

Rhodamine-modified fluorescent half-sandwich iridium and ruthenium complexes: potential application as bioimaging and anticancer agents

2019 ◽  
Vol 48 (15) ◽  
pp. 4788-4793 ◽  
Author(s):  
Wenli Ma ◽  
Lihua Guo ◽  
Zhenzhen Tian ◽  
Shumiao Zhang ◽  
Xiangdong He ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Potential Application ◽  
Ruthenium Complexes ◽  
Anticancer Complexes ◽  
Half Sandwich

Most half-sandwich metal anticancer complexes are non-fluorescent, which results in an uncertain mechanism of action (MoA).

scholarly journals CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy

2016 ◽  
Vol 7 (3) ◽  
pp. 196-210 ◽  
Author(s):  
Huiying Sun ◽  
Sanjay N. Mediwala ◽  
Adam T. Szafran ◽  
Michael A. Mancini ◽  
Marco Marcelli
Keyword(s):  
Androgen Receptor ◽  
Mechanism Of Action ◽  
Full Length ◽  
In Vivo Efficacy ◽  
Activity Mechanism

Advancements on Adjuvanticity of Bioactive Inorganic and Organic Compounds

2021 ◽  
Vol 21 ◽  
Author(s):  
Jhimli Banerjee ◽  
Sananda Dey ◽  
Kazi Monjur Ali ◽  
Biplab Giri ◽  
Sandeep Kumar Dash
Keyword(s):  
Organic Compounds ◽  
Mechanism Of Action ◽  
Medical Science ◽  
Future Perspectives ◽  
Long Term Effects ◽  
Current Trends ◽  
Inorganic Substances ◽  
Successful Vaccine ◽  
Challenging Situation

Background: Regardless of the enormous success of vaccines over decades, the formulation of biocompatible and highly effective vaccines is still insufficient for combating new pathogens. Discussion: The degree of effectiveness of any vaccine largely depends on the choice of appropriate adjuvant. Along with the optimum biocompatibility, an ideal adjuvant must be biodegradable, economical and easy to manufacture. To date, various organic and inorganic substances are used as adjuvant to augment the effectiveness of the vaccine. Immunological adjuvant is essentials for strong and long-term effects against various pathogens. However, there are a very limited number of licensed adjuvant are available for formulation of a successful vaccine. This produces a challenging situation in medical science. Conclusion: The present review concisely summarizes the mechanism of action of various bioactive organic and inorganic immunological adjuvant, their limitations and future perspectives for their appropriate modification. Current trends of anticancer therapies using immunological adjuvant has also highlighted in this review.

Pharmacological applications of phlorotannins: A comprehensive review

2020 ◽  
Vol 17 ◽  
Author(s):  
Ahsan Javed ◽  
Muhammad Bilal Hussain ◽  
Ali Tahir ◽  
Marwa Waheed ◽  
Ahsan Anwar ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Brown Algae ◽  
Food Sources ◽  
Traditional Food ◽  
Pharmacological Properties ◽  
Comprehensive Review ◽  
Beneficial Uses ◽  
Marine Products ◽  
Antioxidant Characteristics ◽  
Activity Mechanism

Background: Seaweeds including marine brown algae are traditional food sources in Asia. Phlorotannins, as the product of polyketide pathway, are mainly found in brown algae. Different properties have been attributed to this group of marine products ranging from anti-allergic to anticancer activity. Mechanism of action is not obvious for all these properties, but there are some explanations for such effects. Objective: The aim of the current study was to review the phlorotannins and to assess the beneficial uses in medicine. Methods: Different databases were explored with the exact terms “Phlorotannin”, “Seaweed” and “Brown Algae”. Data assembly was finalized by June 2019. The papers showing the effects of phlorotannins in medicine were gathered and evaluated for further assessment. Results: General physiological aspects of phlorotannins were firstly evaluated. Different arrays of pharmacological properties ranging from anti-diabetic activity to cancer treatment were found. The mechanism of action for some of these beneficiary properties has been confirmed through rigorous examinations, but there are some features with unknown mechanisms. Conclusion: Phlorotannins are characterized as a multifunctional group of natural products. Potential antioxidant characteristics could be attributed to preventive and/or their curative role in various diseases.

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