The protein tyrosine kinase Tec regulates mast cell function

2009 ◽  
Vol 39 (11) ◽  
pp. 3228-3238 ◽  
Author(s):  
Uwe Schmidt ◽  
Anastasia Abramova ◽  
Nicole Boucheron ◽  
Eva Eckelhart ◽  
Alexandra Schebesta ◽  
...  
Keyword(s):  
Mast Cell ◽  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Cell Function ◽  
Protein Tyrosine

Bradykinin- and substance P-induced edema formation in the hamster cheek pouch is tyrosine kinase dependent

2007 ◽  
Vol 103 (1) ◽  
pp. 184-189 ◽  
Author(s):  
Israel Rubinstein
Keyword(s):  
Substance P ◽  
Tyrosine Kinase ◽  
Intracellular Signaling ◽  
Protein Tyrosine Kinase ◽  
Cell Function ◽  
Cheek Pouch ◽  
Induced Responses ◽  
Hamster Cheek Pouch ◽  
Endothelial Cell Function ◽  
Protein Tyrosine

The purpose of this study was to determine whether protein tyrosine kinase, a ubiquitous family of intracellular signaling enzymes that regulates endothelial cell function, modulates bradykinin- and substance P-induced increase in macromolecular efflux from the intact hamster cheek pouch microcirculation. Using intravital microscopy, I found that suffusion of bradykinin or substance P (each, 0.5 and 1.0 μM) onto the cheek pouch elicited significant, concentration-dependent leaky site formation and increase in clearance of fluorescein isothiocyanate-dextran (FITC-dextran; molecular mass, 70 kDa; P < 0.05). These responses were significantly attenuated by suffusion of genistein (1.0 μM) or tyrphostin 25 (10 μM), two structurally unrelated, nonspecific protein tyrosine kinase inhibitors ( P < 0.05). Conceivably, the kinase(s) involved in this process could be agonist specific because genistein was more effective than tyrphostin 25 in attenuating bradykinin-induced responses while the opposite was observed with substance P. Both inhibitors had no significant effects on adenosine (0.5 M)-induced responses ( P > 0.5). Collectively, these data suggest that the protein tyrosine kinase metabolic pathway modulates, in part, the edemagenic effects of bradykinin and substance P in the intact hamster cheek pouch microcirculation in a specific fashion.

scholarly journals Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants

FEBS Letters ◽  
2010 ◽  
Vol 584 (24) ◽  
pp. 4933-4940 ◽  
Author(s):  
Reuben P. Siraganian ◽  
Rodrigo O. de Castro ◽  
Emilia A. Barbu ◽  
Juan Zhang
Keyword(s):  
Mast Cell ◽  
Tyrosine Kinase ◽  
Cell Signaling ◽  
Protein Tyrosine Kinase ◽  
Screening Methods ◽  
Protein Tyrosine

scholarly journals Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in FcɛRI-mediated mast cell activation

2003 ◽  
Vol 8 (10) ◽  
pp. 825-836 ◽  
Author(s):  
Shinkou Kyo ◽  
Kiyonao Sada ◽  
Xiujuan Qu ◽  
Koichiro Maeno ◽  
S. M. Shahjahan Miah ◽  
...  
Keyword(s):  
Mast Cell ◽  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Cell Activation ◽  
Negative Regulation ◽  
Mast Cell Activation ◽  
Protein Tyrosine ◽  
Ubiquitin Protein Ligase

Protein tyrosine kinase Syk in mast cell signaling

2002 ◽  
Vol 38 (16-18) ◽  
pp. 1229-1233 ◽  
Author(s):  
Reuben P Siraganian ◽  
Juan Zhang ◽  
Katsuhiro Suzuki ◽  
Kiyonao Sada
Keyword(s):  
Mast Cell ◽  
Tyrosine Kinase ◽  
Cell Signaling ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine
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