Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchyma

2005 ◽  
Vol 35 (4) ◽  
pp. 1076-1085 ◽  
Author(s):  
Angela?S. Archambault ◽  
Julia Sim ◽  
Mary?Ann?T. Gimenez ◽  
John?H. Russell
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Migration ◽  
T Cell ◽  
T Cell Migration ◽  
The Central Nervous System ◽  
Central Nervous System Parenchyma

scholarly journals Recurrent natalizumab-related aseptic meningitis in a patient with multiple sclerosis

2017 ◽  
Vol 23 (10) ◽  
pp. 1424-1427 ◽  
Author(s):  
Robert W Foley ◽  
Nathan T Tagg ◽  
Matthew K Schindler ◽  
Kaylan M Fenton ◽  
Daniel S Reich ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Monoclonal Antibody ◽  
Nervous System ◽  
Cell Migration ◽  
Aseptic Meningitis ◽  
Cns Infection ◽  
T Cell Migration ◽  
Humanized Monoclonal Antibody ◽  
The Central Nervous System

Natalizumab is a recombinant humanized monoclonal antibody that decreases T-cell migration into the central nervous system (CNS) through α4 integrin:adhesion-molecule inhibition, thereby increasing the risk for opportunistic CNS infection. Herein, we report a case of infusion-associated aseptic meningitis in a patient receiving natalizumab.

Chemotropic Molecules: Guides for Axonal Pathfinding and Cell Migration During CNS Development

Physiology ◽  
2003 ◽  
Vol 18 (3) ◽  
pp. 130-136 ◽  
Author(s):  
Fernando de Castro
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Migration ◽  
Complex Pattern ◽  
Axonal Pathfinding ◽  
Cns Development ◽  
The Central Nervous System

Different molecules (netrins, semaphorins, slits) with chemotropic functions and their receptors (neogenin, DCC, neuropilins, plexins, robos) have been identified that guide axons during development of the nervous system to establish the complex pattern of connections among a large number of neurons. These molecules have been recently identified to play a role in cell migration of the central nervous system during development.

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